Alginate antacid (Gaviscon DA) chewable tablets reduce esophageal acid exposure in Chinese patients with gastroesophageal reflux disease and heartburn symptoms

Yuan, Yao; Fang, Jing; Zou, Danping; Levinson, Nigel; Jenner, Bartosz; Wilkinson, Joanne

doi:10.1111/1751-2980.12406

Cited by 9 publications

(7 citation statements)

References 24 publications

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“…diabetic foot ulcers (DFUs) due to their biocompatible, adhesive, antibacterial and hemostatic properties. 112,114,116,117 The purpose of the study proposed by Akiyode and Boateng 112 was to investigate two bioactive polysaccharide polymers kappa-carrageenan (CARR) and sodium alginate (SA) incorporated with microbial biosurfactants (BSs) as medicated wafer dressings for potential application in chronic wounds. Wafers were loaded with BSs at concentrations of 0.1% and 0.2% rhamnolipids (RL) and 0.1% and 5% sophorolipids (SL).…”

Section: Mucoadhesive Drug Delivery Systemsmentioning

confidence: 99%

Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Jadach¹,

Świetlik²,

Froelich³

2022

Journal of Pharmaceutical Sciences

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Alginates are naturally occurring polymers revealing low toxicity, good biocompatibility and biodegradability, excellent gelling and thickening properties, as well as low production cost and good availability. One of the most important features typical for alginates is the ability to undergo ionotropic gelation which is gel formation process occurring upon the contact with cations. Because of their advantageous properties, alginates have been extensively utilized in food and pharmaceutical industries. In this review the current knowledge regarding the most recent studies involving both popularly applied dosage forms, like tablets or hydrogels, and novel advanced drug delivery systems applied in targeted therapies are summarized and discussed. The presented studies indicate that although sodium alginate is a well-established polymer, it is still widely applied as pharmaceutical excipient and the presented research studies indicate that there are still research areas that can be explored and provide innovation in drug delivery systems.

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Section: Mucoadhesive Drug Delivery Systemsmentioning

confidence: 99%

Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Jadach¹,

Świetlik²,

Froelich³

2022

Journal of Pharmaceutical Sciences

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“…Data from all the patients were accumulated, and the results showed significant benefits of GDA statistically. It was concluded that GDA is safe and effective for the treatment of GORD …”

Section: Resultsmentioning

confidence: 99%

Raft‐forming polysaccharides for the treatment of gastroesophageal reflux disease (GORD): Systematic review

Yousaf

Nirwan

Smith

et al. 2019

J of Applied Polymer Sci

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Gastroesophageal reflux disease (GORD) is a common condition induced by unwarranted reflux of gastric and duodenal contents into the esophagus, and insufficient clearance of refluxate from it. Pharmaceutical formulations possessing raft‐forming capability offers an excellent alternative to conventional treatment options to treat uncomplicated GORD. These formulations typically contain a polymer, which performs distinctively upon contact with gastric acid and develops a foam‐like structure that can float on gastric contents. This review aims to feature research articles and patents that cover this topic. After undergoing a standardized literature search following preferred reporting items for systematic reviews and meta‐analyses guidelines, we have included 38 research articles and 18 patents describing the role of raft‐forming polymers in the treatment of GORD. This is a comprehensive review of formulation/testing of raft‐forming polymers. As expected, the majority of the studies focused on alginate; however, fewer studies have reported the use of pectin, xanthan gum, and raw psyllium fibers (husk). Moreover, it can be concluded from this comprehensive systematic review that a detailed characterization of raft‐forming formulations, type, and concentration of used active and inactive materials and different formulations factors are essential for the development of successful anti‐reflux raft‐forming formulations. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48012.

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“…Several studies also proved that alginate could decrease acid exposure in the postprandial period. [235][236][237] Alginate showed a better clinical effect in reducing reflux-related symptoms than placebo or non-alginate antiacid. 238,239 In a meta-analysis, alginate-antacid also showed 60.0% relative benefit compared to placebo.…”

Section: Alginate-based Therapymentioning

confidence: 99%

2020 Seoul Consensus on the Diagnosis and Management of Gastroesophageal Reflux Disease

Jung

Tae

Song

et al. 2021

J Neurogastroenterol Motil

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Based on a meta-analysis of 19 estimated acid-exposure time values in Asians, the reference range upper limit for esophageal acid exposure time was 3.2% (95% confidence interval, 2.7-3.9%) in the Asian countries. Esophageal manometry and novel impedance measurements, including mucosal impedance and a post-reflux swallow-induced peristaltic wave, are promising in discrimination of GERD among different reflux phenotypes, thus increasing its diagnostic yield. We also propose a long-term strategy of evidence-based GERD treatment with proton pump inhibitors and other drugs.

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Alginate antacid (Gaviscon DA) chewable tablets reduce esophageal acid exposure in Chinese patients with gastroesophageal reflux disease and heartburn symptoms

Cited by 9 publications

References 24 publications

Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Raft‐forming polysaccharides for the treatment of gastroesophageal reflux disease (GORD): Systematic review

2020 Seoul Consensus on the Diagnosis and Management of Gastroesophageal Reflux Disease

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