Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Jadach, Barbara; Świetlik, Weronika; Froelich, Anna

doi:10.1016/j.xphs.2021.12.024

Cited by 85 publications

(47 citation statements)

References 110 publications

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“…As shown, eye facsimiles crosslinked with calcium lactate exhibited a molecular release of dextran that was initially linear, but rapidly increased to approach 65% of the loading concentration, C , after a few hours. This rapid, sigmoidal release was consistent with previous studies using calcium-based crosslinking of alginates (reviewed in [ 52 ]) but was undesirable for the multi-day testing desired for the μ-Eye system. By contrast, eye facsimiles crosslinked with zinc chloride produced a much slower, linear release of dextran over 24 h that was also consistent with the reported literature [ 53 , 54 ].…”

Section: Methodssupporting

confidence: 87%

A Microfluidic Eye Facsimile System to Examine the Migration of Stem-like Cells

2022

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Millions of adults are affected by progressive vision loss worldwide. The rising incidence of retinal diseases can be attributed to damage or degeneration of neurons that convert light into electrical signals for vision. Contemporary cell replacement therapies have transplanted stem and progenitor-like cells (SCs) into adult retinal tissue to replace damaged neurons and restore the visual neural network. However, the inability of SCs to migrate to targeted areas remains a fundamental challenge. Current bioengineering projects aim to integrate microfluidic technologies with organotypic cultures to examine SC behaviors within biomimetic environments. The application of neural phantoms, or eye facsimiles, in such systems will greatly aid the study of SC migratory behaviors in 3D. This project developed a bioengineering system, called the μ-Eye, to stimulate and examine the migration of retinal SCs within eye facsimiles using external chemical and electrical stimuli. Results illustrate that the imposed fields stimulated large, directional SC migration into eye facsimiles, and that electro-chemotactic stimuli produced significantly larger increases in cell migration than the individual stimuli combined. These findings highlight the significance of microfluidic systems in the development of approaches that apply external fields for neural repair and promote migration-targeted strategies for retinal cell replacement therapy.

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Section: Methodssupporting

confidence: 87%

A Microfluidic Eye Facsimile System to Examine the Migration of Stem-like Cells

2022

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“…A substance is defined as a natural polymer "generally considered safe" by the US Food and drug administration. Sodium alginate is a linear anionic polysaccharide compound whose molecular chain is composed of β-D-mannuronic acid and α-L-guluronic acid is polymerized by (1)(2)(3)(4) glycosidic bond [21]. A large number of negatively charged carboxyl groups [22] in sodium alginate interact with the positively charged primary amino groups in chitosan to form composite microspheres.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Sunscreen Effects via Layer-By-Layer Self-Assembly of Chitosan/Sodium Alginate/Calcium Chloride/EHA

Zeng

Yang

et al. 2022

Molecules

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The sunscreen nanocapsules were successfully synthesized by the way of layer-by-layer self-assembly using charged droplets (prepared by emulsification of LAD-30, Tween-80 and EHA (2-Ethylhexyl-4-dimethylaminobenzoate)) as templates. Chitosan/sodium alginate/calcium chloride were selected as wall materials to wrap EHA. The emulsions with the ratio of Tween-80 to EHA (1:1) were stable. A stable NEI negative emulsion can be obtained when the ratio of Tween-80 and LAD-30 was 9:1. Chitosan solutions (50 kDa, 0.25 mg/mL) and sodium alginate solutions (0.5 mg/mL) were selected to prepare nanocapsules. The nanocapsules were characterized via some physico-chemical methods. Based on the synergistic effects of the electrostatic interaction between wall materials and emulsifiers, EHA was effectively encapsulated. DLS and TEM showed that the sunscreen nanocapsules were dispersed in a spherical shape with nano-size, with the increasing number of assembly layers, the size increased from 155 nm (NEI) to 189 nm (NEII) to 201 nm (NEIII) and 205 nm after solidification. The release studies in vitro showed sustained release behavior of the nanocapsules were observed with the increase of the number of deposition layers, implying a good coating effect. The sunscreen nanocapsules could control less than 50% the release of EHA after crosslinking of calcium chloride and sodium alginate, which also could effectively avoid the stimulation of the sun protection agent on the skin.

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“…The residence time of the formulation in the absorption site is a crucial issue for buccal formulations aimed to produce systemic effects. One of the most attractive strategies for ensuring a proper and long-lasting retention of the formulation on the oral mucosa is based on the use of mucoadhesive polymers, capable of establishing molecular interactions with mucosa components, allowing a durable anchorage of the formulation [ 9 , 10 , 11 ]. Polymeric and lipid nanoparticles are suitable nanocarriers for buccal drug administration [ 12 , 13 ], and liposomes stand out for their high biocompatibility and versatility, allowing these lipid vesicles to be loaded with hydrophilic or hydrophobic drugs.…”

Section: Introductionmentioning

confidence: 99%

Development of a Mucoadhesive Vehicle Based on Lyophilized Liposomes for Drug Delivery through the Sublingual Mucosa

et al. 2022

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A pharmaceutical vehicle based on lyophilized liposomes is proposed for the buccal administration of drugs aimed at systemic delivery through the sublingual mucosa. Liposomes made of egg phosphatidylcholine and cholesterol (7/3 molar ratio) were prepared and lyophilized in the presence of different additive mixtures with mucoadhesive and taste-masking properties. Palatability was assayed on healthy volunteers. The lyophilization cycle was optimized, and the lyophilized product was compressed to obtain round and capsule-shaped tables that were evaluated in healthy volunteers. Tablets were also assayed regarding weight and thickness uniformities, swelling index and liposome release. The results proved that lyophilized liposomes in unidirectional round tablets have palatability, small size, comfortability and buccal retention adequate for sublingual administration. In contact with water fluids, the tablets swelled, and rehydrated liposomes were released at a slower rate than permeation efficiency determined using a biomimetic membrane. Permeability efficiency values of 0.72 ± 0.34 µg/cm2/min and 4.18 ± 0.95 µg/cm2/min were obtained for the liposomes with and without additives, respectively. Altogether, the results point to the vehicle proposed as a liposomal formulation suitable for systemic drug delivery through the sublingual mucosa.

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Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Cited by 85 publications

References 110 publications

A Microfluidic Eye Facsimile System to Examine the Migration of Stem-like Cells

A Microfluidic Eye Facsimile System to Examine the Migration of Stem-like Cells

Enhanced Sunscreen Effects via Layer-By-Layer Self-Assembly of Chitosan/Sodium Alginate/Calcium Chloride/EHA

Development of a Mucoadhesive Vehicle Based on Lyophilized Liposomes for Drug Delivery through the Sublingual Mucosa

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