Alfaxalone compared with ketamine for induction of anaesthesia in horses following xylazine and guaifenesin

Evaluation of intravenous administration of alfaxalone, propofol, and ketamine-diazepam for anesthesia in alpacas

“…This dose rate is similar to that reported for use in sheep Torres et al 2012;Walsh et al 2012), in rabbits (2-3 mg kg À1 ) (Grint et al 2008), and dogs (1.9-2.6 mg kg À1 ) (Ferr e et al 2006;Muir et al 2008;Jim enez et al 2012;Maney et al 2013). Using alfaxalone in combination with other sedatives may allow the dose to be reduced to 1 mg kg À1 IV in other species (Leece et al 2009;Goodwin et al 2012;Keates et al 2012). Mean induction dose for ketamine and diazepam used in this study was 4.4 and 0.2 mg kg À1 IV, respectively.…”

“…The use of the new formulation of alfaxalone has been reported in dogs (Muir et al 2008;Maddern et al 2010), cats (Muir et al 2009;Mathis et al 2012), horses (Goodwin et al 2012;Keates et al 2012), rabbits (Marsh et al 2009), pigs (Keates 2003), sheep Walsh et al 2012), iguanas, amphibians, turtles, and fish. To the authors' knowledge, there are no publications concerning the administration of alfaxalone to camelids.…”

The cardiopulmonary effects and quality of anesthesia after induction with alfaxalone in 2‐hydroxypropyl‐β‐cyclodextrin in dogs and cats: a systematic review

“…() (LOE1; ROB2) and Keates et al . () (LOE3; ROB3) reported no significant difference in these time points between the agents (Keates & Whittem, ; Suarez et al ., ). However, Maney et al .…”

“…() (LOE3; ROB4) and Keates et al . () (LOE3; ROB3), respectively (Ambros et al ., ; Keates & Whittem, ). Studies that evaluated alfaxalone‐HPCD without comparing it with other agents reported a low (0–4%) incidence of apnea when the agent was injected over 40–60 sec at dosages close to the recommended rate (Muir et al ., ; Maddern et al ., ; Keates & Whittem, ; O'Hagan et al ., ,b).…”

“…The quality of anesthesia produced by was assessed in healthy, debilitated, and young patients (Muir et al ., ; Psatha et al ., ; Mathis et al ., ; O'Hagan et al ., ,b; Amengual et al ., ). Trials have also been carried out to assess the possibility of using the agent in the anesthesia of other animals, including horses, sheep, goldfish, crocodiles, and pigs (Andaluz et al ., ; Granados et al ., ; Keates et al ., ; Torres et al ., ; Bauquier et al ., ; Moll et al ., ; Olsson et al ., ; Santos Gonzalez et al ., ).…”