Aldahol high-level disinfectant

Miner, Norman; Harris, Valerie; Cao, Thuy Dung; Ebron, Towanda; Lukomski, Natalie

doi:10.1016/j.ajic.2009.08.009

Cited by 13 publications

(8 citation statements)

References 10 publications

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“…Miner et al [10] demonstrated that products containing concentrations of ≤20% w/w isopropanol and ≤8% potassium acetate in combination with ≤3.5% w/w glutaraldehyde at alkaline pH values killed 6 log of mycobacteria – Mycobacterium bovis var BCG, M. terrae ATCC 15755, and glutaraldehyde-resistant M. chelonae var abscessus ATCC 14472 – within 10 min at 20°C.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of mycobactericidal activity of selected chemical disinfectants and antiseptics according to European standards

2014

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BackgroundThe history of the investigation of standardized mycobactericidal activity of disinfectants and antiseptics is not very long. There is growing interest among the manufacturers of disinfectants in carrying out research on the antimicrobial activities in accordance with European standards (EN). This research could facilitate the introduction of high-quality disinfectants to the market. The aim of this study was to evaluate the mycobactericidal activity of selected chemical disinfectants and antiseptics used in the medical and veterinary fields.Material/MethodsThis study included 19 products submitted to the National Medicines Institute in Poland for evaluation of mycobactericidal activity. These products contain in their composition active substances belonging to different chemical groups, including aldehydes, alcohols, amines, quaternary ammonium compounds, phenols, guanidine, and oxidizing compounds. This study, conducted according to the manufacturers’ description of the preparations, was carried out in accordance with European standards, which also met the Polish standards: PN-EN 14204: 2013, PN-EN 14348: 2006, and PN-EN 14563: 2012.ResultsTested products for disinfection and antiseptics containing active substances from different chemical groups showed high mycobactericidal activity and met the requirements of the appropriate European standards in most cases. In the case of products containing guanidine and amine compounds, the concentration of active ingredients used in the test and the test conditions specified by the manufacturer did not provide the mycobactericidal activity required by the standards.ConclusionsPrior to the launch of a new product on the market, it is important to establish the appropriate usage and testing conditions of the preparation, such as its practical concentration, contact time, and environment condition (clean or dirty).

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Section: Discussionmentioning

confidence: 99%

Evaluation of mycobactericidal activity of selected chemical disinfectants and antiseptics according to European standards

2014

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“…During the suspension test, control strains were reduced to no detectable bacterial counts within 10 minutes of exposure to Cidex (1.5% GTA) at 25°C, except for the slow-growing species M. avium, M. terrae, and M. bovis BCG, which required longer contact times of 15 to 30 minutes (Table 1). Reduction to no detectable bacterial counts was achieved for all control strains within 5 minutes of exposure to Aldahol (1.8% GTA), a GTA-based product containing isopropanol and potassium acetate, 24 at both 20°C and 25°C (Table 1). The carrier-disk test yielded similar results with reduction to no viable bacteria for all GTA-susceptible strains and GTA-based products tested (Table 2).…”

Section: Resultsmentioning

confidence: 99%

Disinfectant Susceptibility Profiling of Glutaraldehyde-Resistant Nontuberculous Mycobacteria

Burgess

Margolis

Gibbs

et al. 2017

Infect. Control Hosp. Epidemiol.

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Objective Activated alkaline glutaraldehyde remains one of the most widely used high-level disinfectant across the world. Yet, several reports have highlighted the potential for nontuberculous mycobacteria to develop high-level resistance to this product. Because aldehyde resistance may lead to cross-resistance to other biocides, we set out to investigate the susceptibility profile of glutaraldehyde-resistant Mycobacterium chelonae and Mycobacterium abscessus isolates to various disinfectant chemistries. Methods High-level disinfectants commonly used in the reprocessing of endoscopes and other heat-sensitive, semicritical medical equipment, including different formulations of aldehyde-based products and oxidizing agents, were tested against ten slow- and fast-growing, glutaraldehyde-susceptible and glutaraldehyde-resistant, Mycobacterium isolates in suspension and carrier tests at different temperatures. Results While peracetic acid- and hydrogen peroxide-based disinfectants (S40™, Resert™ XL, Reliance™ DG) efficiently killed all of the Mycobacterium isolates, glutaraldehyde- and ortho-phthalaldehyde-based products (Cidex®, Aldahol®, Cidex® OPA) showed variable efficacy against glutaraldehyde-resistant strains despite the ability of some formulations (Aldahol®) to overcome the resistance of some of these isolates, especially when the temperature was increased from 20 to 25°C. Conclusions Application permitting, oxidizing chemistries may provide a safe alternative to aldehyde-based products, particularly in the case of GTA-resistant mycobacterial outbreaks.

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“…The results of this study were similar to those of the current study with one difference; in Miner et al, a temperature between 20-25°C was considered, but the current study was done at room temperature. 16 da Silva et al evaluated the effects of 6 different disinfectants on the elimination of five species of bacteria and their effects on a resin acrylic surface texture. Performed in 2007, their study aimed to highlight the effects of disinfectant (sodium hypochlorite 1%, chlorhexidine digluconate 2%, chlorhexidine 2%, vinegar 100%, and a denture cleaning pill with a perborate sodium base and perborate sodium 3.8%) in disinfecting acrylic resin samples (n = 10) contaminated with Candida albicans, Streptococcus mutans, S. aureus, E. coli, and B. subtilis; the remaining colonies were measured in CFU in a laboratory.…”

Section: Discussionmentioning

confidence: 99%

Effects of Different Times of Glutaraldehyde 2% on Bacillus subtilis Spores (In Vitro)

et al. 2017

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Aldahol high-level disinfectant

Cited by 13 publications

References 10 publications

Evaluation of mycobactericidal activity of selected chemical disinfectants and antiseptics according to European standards

Evaluation of mycobactericidal activity of selected chemical disinfectants and antiseptics according to European standards

Disinfectant Susceptibility Profiling of Glutaraldehyde-Resistant Nontuberculous Mycobacteria

Effects of Different Times of Glutaraldehyde 2% on Bacillus subtilis Spores (In Vitro)

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