Alcohol Consumption and Its Adverse Effects in Poland in Years 1950–2005

Bielińska-Kwapisz, Agnieszka; Mielecka-Kubień, Zofia

doi:10.1155/2011/870714

Cited by 8 publications

(2 citation statements)

References 50 publications

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“…Alcohol acts as a negative allosteric modulator that blocks the open channel; ivermectin can antagonize the inhibitory effect of ethanol on P2X 4 and is thought to interfere with ethanol binding to the channel ( Kanellopoulos et al, 2021 ). Chronic alcohol consumption is associated with cirrhosis, dementia, cardiovascular disease (such as hypertension, heart failure, atrial fibrillation), neuropathy, nutritional deficiencies, and certain cancers ( Bielinska-Kwapisz and Mielecka-Kubien, 2011 ; Obad et al, 2018 ).…”

Section: Clinically Available Drugsmentioning

confidence: 99%

Neuropathic pain: Mechanisms and therapeutic strategies

Petroianu

Aloum

Adem

2023

Front. Cell Dev. Biol.

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The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The number of pharmacodynamically distinct and clinically available medications is low and the successes achieved modest. Pain Medicine practitioners are confronted with the ethical dichotomy imposed by Hippocrates: On one hand the mandate of primum non nocere, on the other hand, the promise of heavenly joys if successful divinum est opus sedare dolorem. We briefly summarize the concepts associated with nociceptive pain from nociceptive input (afferents from periphery), modulatory output [descending noradrenergic (NE) and serotoninergic (5-HT) fibers] to local control. The local control is comprised of the “inflammatory soup” at the site of pain origin and synaptic relay stations, with an ATP-rich environment promoting inflammation and nociception while an adenosine-rich environment having the opposite effect. Subsequently, we address the transition from nociceptor pain to neuropathic pain (independent of nociceptor activation) and the process of sensitization and pain chronification (transient pain progressing into persistent pain). Having sketched a model of pain perception and processing we attempt to identify the sites and modes of action of clinically available drugs used in chronic pain treatment, focusing on adjuvant (co-analgesic) medication.

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Section: Clinically Available Drugsmentioning

confidence: 99%

Neuropathic pain: Mechanisms and therapeutic strategies

Petroianu

Aloum

Adem

2023

Front. Cell Dev. Biol.

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“…A lengyel eset az a Szolidaritás szakszervezet által 1980-ban elindított tüntetéssorozattal kapcsolatos (Bielinska-Kwapisz & Mielecka-Kubien, 2011;Moskalewicz, 1993). A tüntetők, mindenekelőtt azért, hogy a hatalom ne tudja kijátszani ellenük a "részeges rendzavarónak" minősítés kártyáját, nemcsak mértékletességet, hanem majdnem teljes absztinenciát vállaltak a tüntetés alatt.…”

Section: A Romániai Alkoholfogyasztás Alakulása Az áLlamszocializmus Idejénunclassified

Liquid Pleasures. Alcohol Control Policy and Society in the Period of Romanian State-socialism

Horváth

2020

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In the context of modern industrial capitalism and the expansion of wage labor, the consumption of alcohol has gradually increased since the 18th century. This growth was present, both in Eastern and Western Europe, also in restructured state-socialist systems after the World War II, like in Romania. The present study analyzes the dynamics of alcohol consumption in the state-socialist period, using as a starting point the alcohol policies of that period. Three phases can be distinguished: alcohol, as considered a stable state income (due to increasing consumption), expanding access as an indicator of prosperity (increasing consumption), the third phase is on restraining consumption opportunities, consequently consumption too. Keywords: social history, alcohol consumption, lifestyle, communism, Romania

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Drogenkonsum als rationale Wahl – dynamische Modelle

Berger

Gautschi

2020

Kriminalität Und Gesellschaft

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Alcohol Consumption and Its Adverse Effects in Poland in Years 1950–2005

Cited by 8 publications

References 50 publications

Neuropathic pain: Mechanisms and therapeutic strategies

Neuropathic pain: Mechanisms and therapeutic strategies

Liquid Pleasures. Alcohol Control Policy and Society in the Period of Romanian State-socialism

Drogenkonsum als rationale Wahl – dynamische Modelle

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