Albumin-induced exfoliation of molybdenum disulfide nanosheets incorporated polycaprolactone/zein composite nanofibers for bone tissue regeneration

Awasthi, Ganesh Prasad; Kaliannagounder, Vignesh Krishnamoorthi; Maharjan, Bikendra; Lee, Ji Yeon; Park, Chan Hee; Kim, Cheol Sang

doi:10.1016/j.msec.2020.111162

Cited by 36 publications

(43 citation statements)

References 51 publications

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“…[28] Similarly, characteristic peaks of PCL appeared at 2941, 2868 (vs; ν(CH)), 1720 (s; ν(CO)), and 1157 cm −1 (s; ν(CO)). [18] The characteristic peaks of PCL and MoS 2 also appeared in PCL/MoS 2 nanofiber membranes. The crystallization nature of the electrospun nanofibers was further evaluated by XRD patterns (Figure 3b).…”

Section: Characterization Of Electrospinning Nanofiber Membranesmentioning

confidence: 96%

“…It was reported that the diameter of electrospun nanofiber would be reduced with the increase of the conductivity of the electrospinning solution. [27] Because of the MoS 2 -induced increase of the conductivity of the electrospinning solution, [18] the average diameters of PCL/MoS 2 were smaller than those of the pure PCL.…”

Section: Characterization Of Electrospinning Nanofiber Membranesmentioning

confidence: 99%

“…[29] And the two major peaks at 21.4° and 23.8° were originated from the crystalline of PCL. [18] The BSA was further characterized by FTIR and XRD (Figure S2, Supporting Information). As the amount of BSA was small in electrospun membrane, the characteristic peak of BSA was not obvious in the spectrum of the membrane.…”

Section: Characterization Of Electrospinning Nanofiber Membranesmentioning

confidence: 99%

“…[17] Awasthi et al reported that PCL/zein/MoS 2 (PZM) composite nanofibrous scaffolds displayed improved osteogenic properties, promising in bone tissue engineering. [18] Yadav et al described that MoS 2reinforced hydroxyapatite (HAP) nanocomposite scaffolds show higher osteogenic potential than HAP alone both in vitro and in vivo. [19] Thus, MoS 2 holds promise in osteogenesis and bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

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Electrospun PCL/MoS₂ Nanofiber Membranes Combined with NIR‐Triggered Photothermal Therapy to Accelerate Bone Regeneration

Liao

Huang

et al. 2021

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Commercially available GBR membranes include polytetrafluoroethylene (PTFE), poly (ε-caprolactone)(PCL), polylactic acid (PLA), polyglycolic acid (PGA), collagen, and so on. [4,5] The ideal GBR membrane should be biocompatible, degradable, and have favorable mechanical properties. [6] However, most commercial GBR membranes are either nondegradable, or not stiff enough to match bone, which limits their application in bone regeneration.Incorporation of functional nanoparticles in GBR membranes would be an effective strategy for elevation of their performance. Bioactive inorganic nanofillers, such as graphene oxide, [7] octacalcium phosphate, [8] and bioactive glass, [9] have been incorporated into GBR membranes to improve the stiffness or osteoconductivity. Recently, nanosized molybdenum disulfide (MoS 2 ) has attracted much attention in biomedical field owing to its fantastic physiochemical properties, biocompatibility, and excellent bioactivities. MoS 2 exhibits low cytotoxicity and genotoxicity, [10,11] since Mo is an important trace element for humans that acts as a cofactor for many redox enzymes and S is also an abundant biological element. [12,13] The addition of MoS 2 in polymers, such as polyacrylonitrile/MoS 2 , chitosan/MoS 2 , and poly vinylidene fluoride/MoS 2 , has been demonstrated to promote cell proliferation. [14][15][16] MoS 2 was also found to have an osteogenic potential. Zhang et al. documented that the nanostructured Electrospun nanofiber membranes have been widely used for guided bone regeneration (GBR). For assistance in bone healing, photothermal therapy which renders moderate heat stimulation to defect regions by near-infrared (NIR) light irradiation has attracted much attention in recent years. Combined with photothermal therapy, novel electrospun poly(ε-caprolactone)/ molybdenum disulfide (PCL/MoS 2 ) nanofiber membranes are innovatively synthesized as GBR for bone therapy, wherein the exfoliated MoS 2 nanosheets served as osteogenic enhancers and NIR photothermal agents. With the doping of MoS 2 , the mechanical properties of nanofiber membranes got improved with the degradation unaffected. The composite PCL/MoS 2 membranes show enhanced cell growth and osteogenic performance compared with PCL alone. Under NIR-triggered mild photothermal therapy, osteogenesis and bone healing are accelerated by using PCL/MoS 2 nanofiber membranes for growth of bone mesenchymal stem cells in vitro and repair of rat tibia bone defect in vivo. The novel nanofiber membranes may be developed as intelligent GBR in the therapy of bone defects.

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Section: Characterization Of Electrospinning Nanofiber Membranesmentioning

confidence: 96%

Section: Characterization Of Electrospinning Nanofiber Membranesmentioning

confidence: 99%

Section: Characterization Of Electrospinning Nanofiber Membranesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Electrospun PCL/MoS₂ Nanofiber Membranes Combined with NIR‐Triggered Photothermal Therapy to Accelerate Bone Regeneration

Liao

Huang

et al. 2021

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“…In a similar trend, electrospun silk fibroin (SF) nanofibrous scaffold functionalized with two-stage hydroxyapatite (HAp) particles have been employed in the bone regeneration application by using critical-sized calvarial bone defect model [115]. Another study used molybdenum disulfide nanosheets incorporated polycaprolactone/zein com-posite nanofibers in the bone tissue regeneration application [116]. In recent years, significant efforts have been put forward in the fabrication of conductive electrospun scaffold for effective bone tissue engineering.…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Balusamy

Anitha

Uyar

2020

Hacettepe Journal of Biology and Chemistry

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E lektro-eğirme yöntemi ile üretilen nanolifler, son yıllarda nanofibröz yapı iskelelerinin geliştirilmesinde büyük ilgi gördü ve biyomimetik yapıları nedeniyle farklı biyomedikal uygulamalarda kullanıldı. Özellikle, elektro-eğirme yöntemi ile üretilen nanolifler doğal hücre dışı matris (ECM), birbirine bağlı gözenekler, geniş yüzey alanı, işlevselleştirme kolaylığı ve hücre adezyonunu, farklılaşmasını ve proliferasyon davranışını etkilemede büyük önem taşıyan mekanik performans dahil olmak üzere birçok faydalı özellik sergiler. Bugüne kadar, çok çeşitli yararlı özellikleri kabul eden bu nanolifler, yara örtüsü ve doku mühendisliği uygulamalarında kullanılmıştır. Bu derlemede, çeşitli malzemelerin ve yaklaşımların kullanımını gösteren birkaç temsili örneklerle bu alanlarda çeşitli çabaların yapıldığını özetlemektedir. Ayrıca, klinik faz transferine ilişkin gelecekteki yön endişeleri tartışılmıştır. Anahtar Kelimeler Elektro-eğirme, nanolif, yara örtüsü, doku mühendisliği.

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High‐Throughput Production of Gelatin‐Based Touch‐Spun Nanofiber for Biomedical Applications

Ismail,

Wu,

Khodamoradi

et al. 2024

Adv Eng Mater

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Nanofiber production techniques have become increasingly important due to their wide range of applications. However, the complex design of the setup and difficulty in scaling up to high production rate have limited the industrial applicability of some of the conventional fiber generation techniques such as electrospinning. Herein, the touch spinning method is scaled up for nanofiber production using a simple rotating drawing setup with polymers that are relevant for biomedical applications such as polyethylene oxide and gelatin. The process is amenable to use of benign solvent such as water and production of a wide variety of submicron‐scale gelatin‐based nanofibers at a high throughput (≈2.45 g hr−1 with the single channel flow), which is an order of magnitude higher than those produced by other fiber generation methods is shown. The parametric study indicates that the fiber production process can be tuned at a desired rate without sacrificing the fiber quality by simply altering the number of drawing rods, the size of the rotating disk, and the number of solution flow supply channels. The utility of this technique for different biomedical applications such as cell culture and air filtration applications is also demonstrated.

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Albumin-induced exfoliation of molybdenum disulfide nanosheets incorporated polycaprolactone/zein composite nanofibers for bone tissue regeneration

Cited by 36 publications

References 51 publications

Electrospun PCL/MoS₂ Nanofiber Membranes Combined with NIR‐Triggered Photothermal Therapy to Accelerate Bone Regeneration

Electrospun PCL/MoS₂ Nanofiber Membranes Combined with NIR‐Triggered Photothermal Therapy to Accelerate Bone Regeneration

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

High‐Throughput Production of Gelatin‐Based Touch‐Spun Nanofiber for Biomedical Applications

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Albumin-induced exfoliation of molybdenum disulfide nanosheets incorporated polycaprolactone/zein composite nanofibers for bone tissue regeneration

Cited by 36 publications

References 51 publications

Electrospun PCL/MoS2 Nanofiber Membranes Combined with NIR‐Triggered Photothermal Therapy to Accelerate Bone Regeneration

Electrospun PCL/MoS2 Nanofiber Membranes Combined with NIR‐Triggered Photothermal Therapy to Accelerate Bone Regeneration

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

High‐Throughput Production of Gelatin‐Based Touch‐Spun Nanofiber for Biomedical Applications

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Product

Resources

About

Electrospun PCL/MoS₂ Nanofiber Membranes Combined with NIR‐Triggered Photothermal Therapy to Accelerate Bone Regeneration

Electrospun PCL/MoS₂ Nanofiber Membranes Combined with NIR‐Triggered Photothermal Therapy to Accelerate Bone Regeneration