Albumin-Impregnated Allograft Filling of Surgical Extraction Sockets Achieves Better Bone Remodeling Than Filling with Either Blood Clot or Bovine Xenograft

Simonffy, László; Minya, Fanni; Trimmel, Bálint; Lacza, Zsombor; Dobó‐Nagy, Csaba

doi:10.11607/jomi.7554

Cited by 11 publications

(11 citation statements)

References 12 publications

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“…Compared to the control group, bone grafting resulted in a denser bone structure but impaired cortical bone formation. Bone macromorphology seems to be similar when compared to simple albumin coated allograft in other studies, although more graft remnants or sequester can be noticed when it was coated with additional gentamycin [32,33]. Bone grafting also affected cortical bone formation.…”

Section: Discussionmentioning

confidence: 59%

“…The values of BS/BV, Tb.Th, Tb.N and Po(tot) of that study correlate with our results, which suggests that the gentamycin component of the double-coating does not influence the microstructure of the augmented area. [33]. It seems that the double-coated allograft forms a denser new alveolar bone, like the single albumin coated allograft.…”

Section: Discussionmentioning

confidence: 99%

“…BA has been successfully used in orthopaedic surgery when severe inflammation indicates joint prosthesis revision [30,31]. In oral surgery, BA showed faster and more complete bone remodelling when used for sinus augmentation or alveolar preservation compared to xenografts [32,33].…”

Section: Methodsmentioning

confidence: 99%

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Alveolar Preservation with Albumin and Gentamycin-Coated Allograft after Third Molar Tooth Removal: A Randomized Clinical Trial

et al. 2021

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Alveolar preservation can minimize bone resorption after tooth removal and additional topical antibiotics might also be considered. The goal of this study was to observe alveolar preservation with albumin and gentamycin-coated allograft compared to unfilled control sockets after mandibular third molar removal. Twenty-two patients were involved, 11 in the control group and 11 in the test group. CBCT analysis and micromorphometric analysis were performed. After one year, graft integration was observed with remaining graft particles. Micromorphometric analysis showed increased density and lower trabeculae formation in the grafted group. The buccal height reduction of the alveolar ridge was significantly lower when alveolar preservation was applied (control: 2.54 ± 2.01 mm, graft: 1.37 ± 1.04 mm, p < 0.05). Horizontal bone loss prevention was not significant. At the distal site of the second molar, the marginal bone level (MBL) was significantly lower in the control group. At the control group, five pockets persisted from the eight initial and all healed in the graft group. Alveolar preservation improves bone formation, helps to preserve the buccal bone crest, and minimizes MBL loss and pocket formation on the adjacent teeth. Thus, it needs to be also considered after third molar surgical removal.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

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Alveolar Preservation with Albumin and Gentamycin-Coated Allograft after Third Molar Tooth Removal: A Randomized Clinical Trial

et al. 2021

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“…It has been proven that albumin is necessary for early bone healing processes and is physiologically present in native bone [ 40 ]. Previous studies with SACBAs in the field of orthopedics and oral surgery have reported uncomplicated healing with a high degree of graft remodeling [ 17 , 19 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…Serum albumin impregnation of allografts can improve osteoinductivity by restoring the albumin content of the graft that has decreased during processing [ 14 , 15 , 16 ]. Previous clinical studies have shown successful graft remodeling and observed bone microarchitecture more resembling native bone with the use of serum albumin-coated bone allografts (SACBAs) than other biomaterials [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Histomorphometric and Micromorphometric Performance of a Serum Albumin-Coated Bone Allograft Combined with A-PRF for Early and Conventional Healing Protocols after Maxillary Sinus Augmentation: A Randomized Clinical Trial

et al. 2021

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The aim of this study was to compare the microarchitecture of augmented bone following maxillary sinus augmentation (MSA) after healing periods of 3 (test) and 6 (control) months using the combination of advanced platelet-rich fibrin (A-PRF) and a serum albumin-coated bone allograft (SACBA). Twenty-six patients with 30 surgical sites who required two-stage MSA were enrolled and grafted with the combination of A-PRF and SACBAs. The surgical sites were randomly allocated to the test or control group. During implant site preparation, 17 bone core biopsy samples were collected from each study group for histological, histomorphometric and micromorphometric analysis. Resonance frequency analysis was performed at the time of implant placement and 6, 8, 10, and 12 weeks postoperatively. The percentage of newly formed bone was 44.89 ± 9.49% in the test group and 39.75 ± 8.15% in the control group (p = 0.100). The results of the µCT analysis showed no significant differences in morphometric parameters between the study groups. The implant stability quotient was not significantly different between the two groups at 10 and 12 weeks postoperatively. Based on these findings, the total treatment time may be reduced by 3 months with the use of A-PRF and SACBAs for two-stage MSA.

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Applications of human and bovine serum albumins in biomedical engineering: A review

Xu,

Hu,

Xue

et al. 2023

International Journal of Biological Macromolecules

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Albumin-Impregnated Allograft Filling of Surgical Extraction Sockets Achieves Better Bone Remodeling Than Filling with Either Blood Clot or Bovine Xenograft

Cited by 11 publications

References 12 publications

Alveolar Preservation with Albumin and Gentamycin-Coated Allograft after Third Molar Tooth Removal: A Randomized Clinical Trial

Alveolar Preservation with Albumin and Gentamycin-Coated Allograft after Third Molar Tooth Removal: A Randomized Clinical Trial

Evaluation of the Histomorphometric and Micromorphometric Performance of a Serum Albumin-Coated Bone Allograft Combined with A-PRF for Early and Conventional Healing Protocols after Maxillary Sinus Augmentation: A Randomized Clinical Trial

Applications of human and bovine serum albumins in biomedical engineering: A review

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