Akut klorprifos-etil zehirlenmesine karşı kafeik asit fenetil ester’in koruyucu etkisi

KARAPEHLİVAN, DEVECİ Hacı Ahmet;

doi:10.1501/vetfak_0000002689

Cited by 6 publications

(1 citation statement)

References 24 publications

(33 reference statements)

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“…In recent years, the application of protective agents to reduce the effects of endogenous oxidative stress and metabolic events related to external factors has been widespread (2,3,16,17,18,21,26,27,28). It assumes that microglia reaction against amyloid plaques with subsequent release of reactive oxygen species is the major damaging factor (20,29).…”

Section: A Csf+ns Normal Tem Appearance Neuronal Nucleus (N) Dendmentioning

confidence: 99%

The Effect of Apocynin on Motor and Cognitive Functions in Experimental Alzheimer’s disease

Akyuva

Önal²,

Parlakpınar³

et al. 2018

Period Biol

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Scope: We investigated the potential beneficial effect of Apocynin (APO) on motor and cognitive functions in experimental Alzheimer's disease (AD). Materials and Methods: Experimental AD was induced in rats by Conclusion: These results indicate that APO can provide neuro-protective effect for motor but not for cognitive performance in experimental AD. INTRODUCTIONI nflammation has been shown to play a vital role in the pathophysiology of the Alzheimer's disease (AD). Microglial cells are responsible for removing the remnants of apoptotic neurons and by doing so they induce an inflammatory response against amyloid plaques via oxidative stress. This theory claims that oxidative stress is the main damaging factor in AD (1, 2, 3). However, antioxidant molecules have not shown to demonstrate significant clinical benefits (2, 4).Recent researches indicate that AD is a brain-specific form of diabetes (5, 6). Hyperglycemia and hyperinsulinemia are correlated with development of 7). Defective insulin signaling, altered levels and/or abnormal activation of components of the insulin signaling pathway, and, more importantly, decreased responsiveness to insulin were found in AD (5,8). In response to infection, trauma or abnormal collection of protein aggregates; TNF-a is produced mainly from microglial cells in the brain. TNF-a levels are increased in AD

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Section: A Csf+ns Normal Tem Appearance Neuronal Nucleus (N) Dendmentioning

confidence: 99%

The Effect of Apocynin on Motor and Cognitive Functions in Experimental Alzheimer’s disease

Akyuva

Önal²,

Parlakpınar³

et al. 2018

Period Biol

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Herbal medicine against genotoxicity of dimethoate, an insecticide, in mammalian somatic cells

Kızılet

Yılmaz

Uysal

2019

Heliyon

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In this study, the genotoxic effects of dimethoate (DIM) were investigated with the in vitro micronucleus test in human peripheral lymphocytes. The ethanol extracts of Rosa canina and Salvia lavandulifolia were used to remove possible genotoxic effects of these substances. For this purpose, different concentrations (0.5-1-2 μg/mL) of dimethoate, DIM + RCeta and DIM + SLeta (1:1 v/v) application groups were prepared and applied to the blood culture. The obtained data were compared with the negative control group that was prepared with dimethyl sulfoxide (DMSO) as solvent and a well-known genotoxic effects of ethyl methanesulfonate (EMS) as positive control group. It was observed in lymphocyte cells that the frequency of MN considerably increased depending on the increasing dose of DIM whereas the nuclear division index (NBI)decreased according to the control group, especially in the last concentration (2 μg/mL). But, as the MN frequency decreased, NBI values approached to control group with 2μg/mL DIM + RCeta and 2μg/mL DIM + SLeta according to DIM application group (P < 0.05). Additionally, RCeta and SLeta were analyzed by gas chromotography-mass spectrometry (GC-MS).

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Effect of subacute malathion application on oxidative stress biomarkers

Deveci

Nur

Kiliçle

2021

Journal of Advances in VetBio Science and Techniques

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Subakut malathion uygulamasının oksidatif stres biyobelirteçlerine etkisiEffect of subacut malathion application on oxidative stress biomarkers ÖZET Bu çalışmada malathionun oksidatif stres biyobelirteçleri ve karaciğer enzimleri üzerine etkileri ile kafeik asit fenetil esterin malathiona karşı koruyuculuğunun araştırılması amaçlandı. Çalışmada her grupta 10 adet hayvan olacak şekilde toplam 40 adet (200-240 g) erişkin erkek Spraque Dawley ırkı rat kullanıldı. Çalışmada kontrol (K) grubuna gavaj yoluyla 5 ml/kg mısır yağı, malathion (MAL) grubuna gavaj yoluyla 40 mg/kg malathion, malathion+kafeik asit fenetil ester (MAL+CAPE) grubuna intraperitoneal yolla CAPE (10 µmol/kg) ve 1 saat sonra gavaj yoluyla malathion (40 mg/kg), kafeik asit fenetil ester (CAPE) grubuna ise intraperitoneal yolla CAPE (10 µmol/kg) uygulandı. 15 günlük uygulama sonunda ratların ketamin/ksilazin anestezi altında intrakardiyak olarak kanları alındı ve hayvanlara servikal dislokasyon yöntemi uygulandı. Alınan kan örneklerinden elde edilen plazmada paraoksonaz (PON), aspartat aminotransferaz (AST), alanin aminotransferaz (ALT) aktiviteleri ile yüksek dansiteli lipoprotein (HDL), malondialdehit (MDA) ve nitrik oksit (NO) düzeyleri analiz edildi. Analiz sonuçları değerlendirildiğinde, kontrol grubuna göre MAL ve MAL+CAPE gruplarında plazma PON aktivitesi ve HDL düzeylerinde azalma (P<0.01) olduğu, AST-ALT aktivitelerinde (P<0,05) MDA ve NO düzeylerinde ise (p<0.01) artış olduğu tespit edildi. Çalışmadan elde edilen sonuçlara göre, malathionun oksidatif stres biyobelirteçlerinde önemli değişiklikler meydana getirdiği, CAPE'nin ise bu değişiklikleri önleyebileceği ve malathion toksikasyonuna karşı koruyucu olabileceği belirlendi

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Akut klorprifos-etil zehirlenmesine karşı kafeik asit fenetil ester’in koruyucu etkisi

Cited by 6 publications

References 24 publications

The Effect of Apocynin on Motor and Cognitive Functions in Experimental Alzheimer’s disease

The Effect of Apocynin on Motor and Cognitive Functions in Experimental Alzheimer’s disease

Herbal medicine against genotoxicity of dimethoate, an insecticide, in mammalian somatic cells

Effect of subacute malathion application on oxidative stress biomarkers

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