Aktuelle Indikationen der Plasmatherapie in der Dermatologie

Boeckmann, Lars; Bernhardt, Thoralf; Schäfer, Mirijam; Semmler, María Eugenia Aubet; Kordt, Marcel; Waldner, Andreas; Wendt, Frank; Sagwal, Sanjeev Kumar; Bekeschus, Sander; Berner, Julia; Kwiatek, Elisa; Frey, Axel W.; Fischer, Tobias; Emmert, Steffen

doi:10.1007/s00105-019-04530-0

Cited by 18 publications

(7 citation statements)

References 25 publications

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“…In the past years, gas plasma technology emerged as a novel tool to target tumors, especially skin [9]. It mainly acts via the deposition of reactive oxygen and nitrogen species (ROS/RNS), placing the field of plasma medicine-which has been reviewed recently [10][11][12]-in the heart of redox biology [13]. Several studies have underlined the anti-melanoma effects of gas plasma treatment in vitro and in vivo [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Combined Toxicity of Gas Plasma Treatment and Nanoparticles Exposure in Melanoma Cells In Vitro

Bekeschus

2021

Nanomaterials

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Despite continuous advances in therapy, cancer remains a deadly disease. Over the past years, gas plasma technology emerged as a novel tool to target tumors, especially skin. Another promising anticancer approach are nanoparticles. Since combination therapies are becoming increasingly relevant in oncology, both gas plasma treatment and nanoparticle exposure were combined. A series of nanoparticles were investigated in parallel, namely, silica, silver, iron oxide, cerium oxide, titanium oxide, and iron-doped titanium oxide. For gas plasma treatment, the atmospheric pressure argon plasma jet kINPen was utilized. Using three melanoma cell lines, the two murine non-metastatic B16F0 and metastatic B16F10 cells and the human metastatic B-Raf mutant cell line SK-MEL-28, the combined cytotoxicity of both approaches was identified. The combined cytotoxicity of gas plasma treatment and nanoparticle exposure was consistent across all three cell lines for silica, silver, iron oxide, and cerium oxide. In contrast, for titanium oxide and iron-doped titanium oxide, significantly combined cytotoxicity was only observed in B16F10 cells.

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Section: Introductionmentioning

confidence: 99%

Combined Toxicity of Gas Plasma Treatment and Nanoparticles Exposure in Melanoma Cells In Vitro

Bekeschus

2021

Nanomaterials

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“…Therapy with cold physical plasmas shows beneficial effects in dermatology, [33,34] especially in wound healing. [10,35] With emergence of novel therapeutic applications and plasma source concepts, [36][37][38] there is an increasing need not only to show treatment efficacy but also to assess toxicological aspects.…”

Section: Discussionmentioning

confidence: 99%

Zebrafish larvae as a toxicity model in plasma medicine

Gandhirajan

Endlich

Bekeschus

2020

Plasma Processes & Polymers

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Plasma technology has emerged as a promising tool in medicine that, however, requires not only efficacy but also toxicological assessments. Traditional cell culture systems are fast and economical, but they lack in vivo relevance; however, rodent models are highly complex and necessitate extended facilities. Zebrafish larvae bridge this gap, and many larvae can be analyzed in well plates in a single run, giving results in 1–2 days. Using the kINPen, we found plasma exposure to reduce hedging rates and viability in a dose‐dependent manner, accompanied with an increase in reactive oxygen species and a decrease of glutathione in plasma‐treated fish. Modest growth alterations were also observed. Altogether, zebrafish larvae constitute a fast, reliable, and relevant model for testing the toxicity of plasma sources.

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“…In such non-healing wounds, the process of wound closure is disturbed or retarded at least in one of the three phases of wound healing. Therapeutic strategies aim for wound disinfection and stimulating applications or procedures to activate the healing process [2,3]. Despite such modern wound dressings and procedures, wounds often persist over months and even years.…”

Section: Introductionmentioning

confidence: 99%

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

Emmert

Pantermehl

Foth

et al. 2021

IJMS

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Skin regeneration is a quite complex process. Epidermal differentiation alone takes about 30 days and is highly regulated. Wounds, especially chronic wounds, affect 2% to 3% of the elderly population and comprise a heterogeneous group of diseases. The prevailing reasons to develop skin wounds include venous and/or arterial circulatory disorders, diabetes, or constant pressure to the skin (decubitus). The hallmarks of modern wound treatment include debridement of dead tissue, disinfection, wound dressings that keep the wound moist but still allow air exchange, and compression bandages. Despite all these efforts there is still a huge treatment resistance and wounds will not heal. This calls for new and more efficient treatment options in combination with novel biocompatible skin scaffolds. Cold atmospheric pressure plasma (CAP) is such an innovative addition to the treatment armamentarium. In one CAP application, antimicrobial effects, wound acidification, enhanced microcirculations and cell stimulation can be achieved. It is evident that CAP treatment, in combination with novel bioengineered, biocompatible and biodegradable electrospun scaffolds, has the potential of fostering wound healing by promoting remodeling and epithelialization along such temporarily applied skin replacement scaffolds.

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Aktuelle Indikationen der Plasmatherapie in der Dermatologie

Cited by 18 publications

References 25 publications

Combined Toxicity of Gas Plasma Treatment and Nanoparticles Exposure in Melanoma Cells In Vitro

Combined Toxicity of Gas Plasma Treatment and Nanoparticles Exposure in Melanoma Cells In Vitro

Zebrafish larvae as a toxicity model in plasma medicine

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

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