Aktivitas Ekstrak Daun Salam (Eugenia polyantha) sebagai Antiinflamasi pada Tikus Putih (Rattus norvegicus)

Agustina, Risna; Indrawati, Dewi Tita; Masruhim, Muhammad Amir

doi:10.25026/jtpc.v3i2.96

Cited by 15 publications

(18 citation statements)

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“…Flavonoid memiliki aktivitas antiinflamasi yang dapat menurunkan sekresi sitokin proinflamasi dan meningkatkan sitokin antiinflmasi 18 . Tanin sebagai antibakteri sehingga proses penyembuhan luka lebih cepat karena mengurangi pertumbuhan bakteri penyebab inflamsi 19 .…”

Section: Penelitian Dimulai Dengan Disetujuinya Penelitian Ini Oleh Komisi Etik Fakultas Kedokteranunclassified

Ekstrak Daun Salam Dalam Meningkatkan Ekspresi Fibroblast Growth Factor Pada Ulkus Traumatik Rongga Mulut

Rosada

Mujayanto

Poetri³

2020

ODONTO : Dental Journal

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Background: Traumatic ulcers are lesions of the oral mucosa caused by mechanical, chemical, and temperature trauma. Traumatic ulcer treatment aims to reduce inflammation, accelerate the healing process, and reduce pain. Bay leaf has anti-inflammatory pharmacological activities. This study aims to determine the effect of bay leaf extract on the expression of fibroblast growth factor in traumatic ulcer oral mucosa in Wistar rats. Method: This is an experimental research with a post-test only control group design, consisting of four groups with 20 sample of male Wistar rats. All animals were injured using a hot burnisher attached to the labial mucosa for 1 second. The gel was applied twice daily until the 3rd and 5th day after the ulcer has formed. Rat mucosal tissues were analyzed by immunohistochemical staining for FGF expressions. Statistical analysis using SPSS Mann-Whitney test. Result: The results showed the mean of cells expressing FGF in the bay gel extract group on the 3rd and 5th days were 8.4 ± 0.8, and 13.6 ± 0.5. Mann Whitney test results showed P<0.05 there is a significant differential expression of FGF traumatic ulcer oral mucosa of experimental animals on days 3 and 5 compared control group. Conclusion: Bay leaf extract increased FGF expression on days 3 and 5 PENDAHULUANUlkus rongga mulut adalah peradangan pada bagian mukosa yang disebabkan kerusakan jaringan epitel rongga mulut dan terbukanya ujung saraf. Traumatik berkaitan adanya trauma mekanik, kimia, dan suhu. Gambaran klinis dari ulkus traumatik merupakan lesi sekunder dengan gambaran khas berupa bentuk soliter bulat, berukuran variatif, kedalaman lesi mencapai lamina propia 1,2,3 .Proses penyembuhan ulkus traumatik dibagi menjadi 3 tahap, fase inflamasi, proliferasi, dan remodeling. Fase inflamasi dibagi menjadi 2 yaitu fase inflamasi awal dan fase inflamasi akhir 4 . Sel yang berperan penting adalah makrofag. Makrofag diklasifikasikan menjadi 2 yaitu makrofag proinflamasi yang berperan pada fase inflamasi awal dan makrofag antiinflamasi atau pro-angiogenik yang berperan pada fase inflamasi akhir.

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Section: Penelitian Dimulai Dengan Disetujuinya Penelitian Ini Oleh Komisi Etik Fakultas Kedokteranunclassified

Ekstrak Daun Salam Dalam Meningkatkan Ekspresi Fibroblast Growth Factor Pada Ulkus Traumatik Rongga Mulut

Rosada

Mujayanto

Poetri³

2020

ODONTO : Dental Journal

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“…Prahstuti et al found that quercetin and phloretin were the most types of flavonoids contained in Salam leaf [17]. These flavonoids could inhibit the activity of cyclooxygenase in arachidonic acid metabolism [8]. Quercetin also could decrease total cholesterol and low-density lipoprotein by inhibiting activity and oxidation of HMG CoA reductase and inhibit the secretion of Apo-B 100.…”

Section: Figure 1: Photomacrography Of Heart Muscle On Negative (A) Amentioning

confidence: 99%

“…Salam leaf is one of the herbal medicines, which have long been used traditionally in Indonesia to control blood glucose, cholesterol, blood pressure, and also to cure gastritis and diarrhea. Salam leaf contains flavonoids, saponins, tannins, gallocatechin, and atsiri oil, which are thought to have an anti-inflammatory and antioxidant effect [8], [9], [10]. A study in Rattus norvegicus rats, anti-inflammation activity of ethanolic extract of Salam leaf was already occurred on low dose after four hours administration [8].…”

Section: Introductionmentioning

confidence: 99%

“…Salam leaf contains flavonoids, saponins, tannins, gallocatechin, and atsiri oil, which are thought to have an anti-inflammatory and antioxidant effect [8], [9], [10]. A study in Rattus norvegicus rats, anti-inflammation activity of ethanolic extract of Salam leaf was already occurred on low dose after four hours administration [8]. Based on these evidences, Salam leaf could have potential in reducing inflammation process on coronary arteries and thereby reduce mortality in ACS.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Salam Leaf (Syzygium polyanthum [Wight] Walp.) Extract on Inflammation in Rat Model of Acute Coronary Syndrome

Hasan¹,

Lindarto²,

Siregar³

et al. 2020

Open Access Maced J Med Sci

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AIM: The aim of the study was to determine the effect of Salam leaf extract on regenerating islet-derived protein 3 β (Reg3β) and C-reactive protein (CRP) in cardiomyocyte of rat model of ACS. METHODS: Thirty-six male Wistar rats were divided into three groups: Negative control group, positive control group (ACS-induced group), and treatment group (ACS-induced group with Salam leaf administration). Macroscopic appearance and histopathology examination were done to ensure the occurrence of infarction. Reg3β and CRP levels were measured and compared between the positive control group and treatment group. RESULTS: There were significantly lower Reg3β and CRP levels in the treatment group than in the positive control group from day 4 to day 14. CONCLUSION: These data suggest that a Salam leaf extract can improve inflammation by decreasing Reg3β and CRP levels in rat model of ACS.

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“…The inflammation process has its functions to destroy, reduce, or localize destructive agents and damaged tissue. Symptoms of inflammation were signed by swelling/edema, redness, heat, pain, and changes in its functions (Agustina et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

In silico and in vitro anti-inflammatory evaluation of 2,6-bis-(3'-ethoxy, 4'-hydroxybenzylidene)-cyclohexanone, 2,6-bis-(3'-Bromo,4'-methoxybenzylidene)-cyclohexanone, and 2,6-bis- (3',4'-dimethoxybenzylidene)-cyclohexanone

2020

J app pharm sci

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The aim of this research is to design the new mono-carbonyl analogs of curcumin, synthesize the molecules, and determine its activity in cyclooxygenase inhibition in vitro and in silico. New design MACs were performed by the Quantitative Structure-Activity Relationship (QSAR) study using the BuildQSAR program. 2,6-bis-(3ʹ-ethoxy, 4ʹ-hydroxybenzylidene)-cyclohexanone, 2,6-bis-(3ʹ-Bromo, 4ʹ-methoxybenzylidene)-cyclohexanone, and 2,6-bis-(3ʹ,4ʹ-dimethoxybenzylidene)-cyclohexanone had been synthesized using aldol condensation reaction. The anti-inflammatory assay was performed to measure the level of malondialdehyde. In silico studies were carried out to evaluate the activity of cyclooxygenase inhibition in cyclooxygenase-1 and cyclooxygenase-2 specific proteins. Molecular operating environment program was used for protocol docking. The results of the QSAR study reveal the good relationship of anti-inflammatory activities. The in vitro anti-inflammatory activities of 6-bis-(3ʹ-ethoxy, 4ʹ-hydroxybenzylidene)cyclohexanone, 2,6-bis-(3ʹ-Bromo, 4ʹ-methoxybenzylidene)-cyclohexanone, and 2,6-bis-(3ʹ,4ʹ-dimethoxybenzylidene)cyclohexanone indicate the promising potential to inhibit cyclooxygenase enzyme with IC 50 13.53 μM, 11.56 μM, and 20.52 μM, respectively. The in silico evaluation showing that O atoms (47, from ketones) of 2,6-bis-(3ʹ-Bromo, 4ʹ-methoxybenzylidene)-cyclohexanone interact with ARG120 and TYR355 through H acceptor.

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Aktivitas Ekstrak Daun Salam (Eugenia polyantha) sebagai Antiinflamasi pada Tikus Putih (Rattus norvegicus)

Cited by 15 publications

References 0 publications

Ekstrak Daun Salam Dalam Meningkatkan Ekspresi Fibroblast Growth Factor Pada Ulkus Traumatik Rongga Mulut

Ekstrak Daun Salam Dalam Meningkatkan Ekspresi Fibroblast Growth Factor Pada Ulkus Traumatik Rongga Mulut

The Effect of Salam Leaf (Syzygium polyanthum [Wight] Walp.) Extract on Inflammation in Rat Model of Acute Coronary Syndrome

In silico and in vitro anti-inflammatory evaluation of 2,6-bis-(3'-ethoxy, 4'-hydroxybenzylidene)-cyclohexanone, 2,6-bis-(3'-Bromo,4'-methoxybenzylidene)-cyclohexanone, and 2,6-bis- (3',4'-dimethoxybenzylidene)-cyclohexanone

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