Aktivitas Antijamur Air Perasan Daun Seledri (Apium graveolens L.) Terhadap Candida albicans Secara In Vitro

Ardelia, Patra Inova; Andrini, Fauzia; Hamidy, Muhammad Yulis

doi:10.26891/jik.v4i2.2010.102-107

Cited by 2 publications

(8 citation statements)

References 6 publications

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“…Kolonisasi C. albicans ini dapat diatasi dengan cara melepas dan merendam pada larutan pembersih gigi tiruan salah satunya yaitu dengan perasan daun seledri. 12,13 Gigi tiruan yang digunakan secara terusmenerus tanpa pembersihan yang adekuat dapat menyebabkan terjadinya akumulasi plak. Salah satu mikroorganisme yang dapat ditemukan pada plak tersebut adalah Candida albicans.…”

Section: Pendahuluanunclassified

“…18 Penggunaan daun seledri sebagai bahan alam yang berkhasiat sebagai obat dapat digunakan sebagai alternatif pembersih gigi tiruan yang efektif menurunkan jumlah koloni C. albicans. 13 Potensi antijamur dari seledri telah diuji terhadap Trichphyton longifuss, C. albicans, Aspergillus flavus, Microsporum canis, Fusarium solani, dan C. glabrata. 19 Pembuatan air perasan daun seledri dapat dilakukan sebagai alternatif pembersih gigi tiruan.…”

Section: Pendahuluanunclassified

“…Banyak peneliti memilih air perasan daun seledri karena tidak membutuhkan alat yang mahal dan cara pembuatannya yang tidak rumit. 13 Penelitian Ardelia dkk. 13 , juga menyatakan bahwa perasan daun seledri dengan konsentrasi 25, 50, dan 100% dapat menghambat pertumbuhan C. albicans.…”

Section: Pendahuluanunclassified

“…13 Penelitian Ardelia dkk. 13 , juga menyatakan bahwa perasan daun seledri dengan konsentrasi 25, 50, dan 100% dapat menghambat pertumbuhan C. albicans. 11 Penelitian yang dilakukan Ardelia dkk.…”

Section: Pendahuluanunclassified

“…11 Penelitian yang dilakukan Ardelia dkk. 13 22,23 Perasan daun seledri yang digunakan dibuat sendiri oleh peneliti dengan cara mengambil tanaman seledri dari Perkebunan Jubung di 25,26 Perendaman cakram nilon termoplastik dengan perasan daun seledri konsentrasi 25, 50, dan 100% menghasilkan nilai yang berbeda. Semakin tinggi konsentrasi perasan daun seledri yang digunakan maka kandungan yang bersifat antijamur akan bereaksi lebih cepat membunuh C. albicans.…”

Section: Pendahuluanunclassified

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Efektivitas perasan daun seledri (Apium graveolens Linn.) sebagai pembersih gigi tiruan terhadap pertumbuhan Candida albicans pada basis gigi tiruan nilon termoplastikThe effectiveness of celery leaf juice (Apium graveolens Linn.) as a denture cleaner against the growth of Candida albicans on thermoplastic nylon denture base

2020

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Pendahuluan: Basis gigi tiruan nilon termoplastik merupakan alternatif pengganti basis gigi tiruan resin akrilik. Pembersihan gigi tiruan diperlukan untuk menjaga basis gigi tiruan agar tetap bersih dari kontaminasi mikroorganisme. Daun seledri merupakan bahan alam yang memiliki kandungan flavonoid, saponin, tanin, dan minyak atsiri yang sudah terbukti bersifat antijamur. Penelitian sebelumnya hanya melihat zona hambat saja. Tujuan penelitian adalah menganalisis efektivitas perasan daun seledri sebagai pembersih gigi tiruan terhadap pertumbuhan Candida albicans pada basis gigi tiruan nilon termoplastik. Metode: Eksperimental laboratoris dengan rancangan penelitian post-test only control group design. Sampel nilon termoplastik berbentuk cakram dengan diameter 10 mm dan tebal 2 mm sebanyak 25 dibagi menjadi 5 kelompok. Sampel dikontaminasi dengan C. albicans setelah direndam dalam kontrol negatif (akuades) selama 6 jam, kontrol positif (tablet effervescent) selama 15 menit, dan perasan daun seledri konsentrasi 25, 50, dan 100% selama 6 jam. Sampel selanjutnya diletakkan dalam media sabouraud dextrose broth (SDB). Pengujian efektivitas perasan daun seledri dilakukan dengan menentukan nilai absorbansi kekeruhan media SDB menggunakan spektrofotometer. Data dianalisis menggunakan one-way ANOVA dan Least Significant Difference (LSD). Hasil: Nilai konsentrasi C. albicans pada kelompok kontrol negatif mendapatkan hasil 0,380 x 108 CFU/mL, kontrol positif mendapatkan hasil 0,310 x 108 CFU/mL, perasan daun seledri konsentrasi 25% mendapatkan hasil 0,243 x 108 CFU/mL, konsentrasi 50% mendapatkan hasil 0,160 x 108 CFU/mL, dan konsentrasi 100% mendapatkan hasil 0,236 x 108 CFU/mL. Simpulan: Perasan daun seledri efektif sebagai pembersih gigi tiruan untuk menghambat pertumbuhan C. albicans, dengan konsentrasi yang efektif sebesar 50%.Kata kunci: Nilon termoplastik, perasan daun seledri, Candida albicans. ABSTRACTIntroduction: Thermoplastic nylon denture base is an alternative to the acrylic resin denture base. Denture cleaning is needed to keep the denture base clean from contamination by microorganisms. Celery leaves are natural ingredients that contain flavonoids, saponins, tannins, and essential oils that have been proven to have antifungal properties. Previous research only observed the inhibitory zone. This research was aimed to analyse the effectiveness of celery leaf juice as a denture cleaner against the growth of Candida albicans on thermoplastic nylon denture base. Methods: Experimental laboratory with a post-test only control group design was conducted towards 25 disc-shaped thermoplastic nylon samples with a diameter of 10 mm and a thickness of 2 mm, and divided into five groups. Samples were contaminated with C. albicans after immersion in the negative control (aquadest) for 6 hours, positive control (effervescent tablets) for 15 minutes, and celery leaf juice with the concentrations of 25, 50, and 100% for 6 hours. The sample was then placed in the Sabouraud-dextrose broth (SDB) medium. The effectiveness of celery leaf juice was tested by determining the absorbance value of SDB media turbidity using a spectrophotometer. Data were analysed using one-way ANOVA and Least Significant Difference (LSD). Results: The concentration value of C. albicans in the negative control group was 0.380 x 108 CFU / mL, the positive control was 0.310 x 108 CFU / mL, the juice of celery leaves with the concentration of 25% was 0.243 x 108 CFU / mL, the concentration of 50% was 0.160 x 108 CFU / mL, and the concentration of 100% was 0.236 x 108 CFU / mL. Conclusion: Celery leaf juice is effective as a denture cleaner to inhibit the growth of C. albicans, with an effective concentration of 50%.Keywords: Thermoplastic nylon, celery leaf juice, Candida albicans.

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Section: Pendahuluanunclassified

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Efektivitas perasan daun seledri (Apium graveolens Linn.) sebagai pembersih gigi tiruan terhadap pertumbuhan Candida albicans pada basis gigi tiruan nilon termoplastikThe effectiveness of celery leaf juice (Apium graveolens Linn.) as a denture cleaner against the growth of Candida albicans on thermoplastic nylon denture base

2020

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The Formulation of Lotion Preparations of Betel Leaf Extract (Piper betle)

Hadning

Kurnyaningtyas

Ghozali

2020

JFAPS

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Betel leaf (Piper betle) contains an essential oil that has extreme antiseptic power (bactericidal and fungicidal). Betel leaf (Piper betle) can be used in the treatment of Tinea versicolor or known in the community as panu. However, its use in the form of leaves is considered impractical by the public and also difficult to obtain. This research formulated betel leaf (Piper betle) into lotion preparations, so its use in the community can be more practical. This study aims to determine the type and concentration of the suspending agent used to produce lotion preparations from betel leaf extract (Piper betle), which has optimal physical quality. This research was an experimental study. The distillation of betel leaf (Piper betle) was carried out to get essential oils. The essential oils of betel leaf (Piper betle), which was used as an active substance in formulations, was 5%. Suspending agents that were used in this study were Arabic gum with concentrations of 10%, 15%, 20%, and CMC Na, with concentrations of 0.25%, 0.5%, and 1%. The formulation of lotion preparations included organoleptic observation, pH test, homogeneity test, and adhesion test. Based on the physical quality test of the lotion preparations that had been conducted, it can be concluded that the lotion preparations of betel leaf extract with 20% concentration of Arabic Gum suspending agent had physical qualities in accordance with lotion dosage criteria.

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Aktivitas Antijamur Air Perasan Daun Seledri (Apium graveolens L.) Terhadap Candida albicans Secara In Vitro

Cited by 2 publications

References 6 publications

The Formulation of Lotion Preparations of Betel Leaf Extract (Piper betle)

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