Airway basophils are increased and activated in eosinophilic asthma

Suzuki, Yoshihiro; Wakahara, Keiko; Nishio, Tomoko; Ito, Satoru; Hasegawa, Yoshinori

doi:10.1111/all.13197

Cited by 44 publications

(54 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, basophil infiltration into skin lesions seems to be more common than previously thought, indicating that they may play important roles in a variety of inflammatory skin diseases . Higher number of basophils were detected in inflammatory skin diseases where eosinophils are present, and those observations are consistent with a recent study which demonstrated a significant correlation between airway basophils and eosinophils in asthma patients …”

Section: The Role Of Basophils In Local Acute Allergic Reactionssupporting

confidence: 90%

“…This suggests that basophils infiltrate lung tissue in asthma patients. Basophils are increased in the sputum not only from allergic but also of non‐allergic asthmatic patients . The highest numbers of basophils were observed in the lungs of patients with eosinophilic asthma, and there is a strong positive correlation between sputum basophil and eosinophil counts .…”

Section: The Role Of Basophils In Asthmamentioning

confidence: 97%

“…Both scenarios are associated with increased CD203c expression on circulating basophils, but no differences were demonstrated for CD63. Suzuki et al analysed basophils in induced sputum from patients with eosinophilic asthma and showed increased surface expression of both CD203c and CD63. However, this study was performed only on stable patients who had no exacerbations for at least the preceding two months.…”

Section: The Role Of Basophils In Asthmamentioning

confidence: 99%

See 2 more Smart Citations

Important and specific role for basophils in acute allergic reactions

Korošec

Gibbs

Rijavec

et al. 2018

Clin Experimental Allergy

View full text Add to dashboard Cite

SummaryIgE‐mediated allergic reactions involve the activation of effector cells, predominantly through the high‐affinity IgE receptor (FcεRI) on mast cells and basophils. Although the mast cell is considered the major effector cell during acute allergic reactions, more recent studies indicate a potentially important and specific role for basophils and their migration which occurs rapidly upon allergen challenge in humans undergoing anaphylaxis. We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response. Finally, we examine the potential role of basophils in asthma exacerbations. Understanding the factors that regulate basophil trafficking and activation might lead to new diagnostic and therapeutic strategies in anaphylaxis and asthma.

show abstract

Section: The Role Of Basophils In Local Acute Allergic Reactionssupporting

confidence: 90%

Section: The Role Of Basophils In Asthmamentioning

confidence: 97%

Section: The Role Of Basophils In Asthmamentioning

confidence: 99%

See 1 more Smart Citation

Important and specific role for basophils in acute allergic reactions

Korošec

Gibbs

Rijavec

et al. 2018

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

“…Their superior ability to release Th2‐type cytokines in comparison to lung mast cells indicates an important pro‐allergic immunomodulatory function and recent studies suggest that epithelial factors, such as TSLP, crucially amplify basophil trafficking and production of Th2‐type cytokines from these cells . Basophil IL‐13 responses have also been shown to correlate closely with LPR lung eosinophilia and their increased numbers have been considered as a biomarker for eosinophilic asthma …”

Section: Role Of Mast Cells and Basophils In Health And Diseasementioning

confidence: 99%

Human mast cells and basophils—How are they similar how are they different?

Varricchi

Raap

Rivellese

et al. 2018

Immunological Reviews

123

116

View full text Add to dashboard Cite

Mast cells and basophils are key contributors to allergies and other inflammatory diseases since they are the most prominent source of histamine as well as numerous additional inflammatory mediators which drive inflammatory responses. However, a closer understanding of their precise roles in allergies and other pathological conditions has been marred by the considerable heterogeneity that these cells display, not only between mast cells and basophils themselves but also across different tissue locations and species. While both cell types share the ability to rapidly degranulate and release histamine following high-affinity IgE receptor cross-linking, they differ markedly in their ability to either react to other stimuli, generate inflammatory eicosanoids or release immunomodulating cytokines and chemokines. Furthermore, these cells display considerable pharmacological heterogeneity which has stifled attempts to develop more effective anti-allergic therapies. Mast cell- and basophil-specific transcriptional profiling, at rest and after activation by innate and adaptive stimuli, may help to unravel the degree to which these cells differ and facilitate a clearer understanding of their biological functions and how these could be targeted by new therapies.

show abstract

“…Mepolizumab (anti‐IL‐5) depletes blood and airway eosinophils, and, clinically , allows down‐titration of oral corticosteroid and a reduction in the frequency of eosinophil‐dependent exacerbations . Basophils also express IL‐5Rα, participate in T2‐mediated inflammatory pathways and have been associated with exacerbation frequency . Whilst basophil progenitors are unlikely to depend on IL‐5 for development, blood basophil counts measured in routine clinical laboratories suggest they decrease following mepolizumab treatment …”

mentioning

confidence: 99%