Airflow Limitation in Smokers Is Associated with Subclinical Atherosclerosis

Iwamoto, Hiroshi; Yokoyama, Akihito; Kitahara, Yoshihiro; Ishikawa, Nobuhisa; Haruta, Yoshinori; Yamane, Kiminori; Hattori, Noboru; Hara, Hitoshi; Kohno, Nobuoki

doi:10.1164/rccm.200804-560oc

Cited by 165 publications

(149 citation statements)

References 42 publications

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“…The degree of endothelial dysfunction was related to lung function and serum C-reactive protein, providing another inflammatory link between COPD and atherosclerosis. Subclinical atherosclerosis is likely to start early in the course of COPD, as suggested by the findings of increased carotid artery intima-media thickness in middle aged smokers with airflow limitation [20].…”

Section: Ischemic Heart Diseasementioning

confidence: 99%

Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art

Patel

Hurst

2011

Expert Review of Respiratory Medicine

136

108

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Section: Ischemic Heart Diseasementioning

confidence: 99%

Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art

Patel

Hurst

2011

Expert Review of Respiratory Medicine

136

108

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“…Similar results were reported by other investigators (38); they found that smoking frequency (pack/year) did not differ between COPD patients with normal CIMT and those with a thickened CIMT. Two other studies reported that CIMT was significantly increased: in smoker COPD patients compared to the smoker control group (37) and in smokers with airflow limitation compared to smokers in the control group and never-smokers in the control group (40). This might be an indication of the influence of other factors leading to intimal thickening other than smoking.…”

Section: Discussionmentioning

confidence: 85%

Atherosclerosis is Associated Comorbidity in Patients with Chronic Obstructive Pulmonary Disease: Ultrasound Assessment of Carotid Intima Media Thickness

Hafez¹,

Sobh²,

Abo-Elkheir³

et al. 2017

Eurasian J Pulmonol

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“…COPD and asthma are conditions with many comorbidities, albeit asthma to a lesser extent than COPD [28][29][30][31]. To date, very limited data have been gathered on the association between asthma and CKD.…”

Section: Discussionmentioning

confidence: 99%

C-reactive protein levels, airflow obstruction, and chronic kidney disease

Funakoshi

Omori

Mihara

et al. 2011

Environ Health Prev Med

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Objectives There is some evidence that chronic obstructive pulmonary disease and chronic kidney disease (CKD) may be related, perhaps through systemic inflammation, which is common to both. However, this relationshiphas not yet been clearly demonstrated. The aim of this study was to investigate the association between airflow obstruction, CKD, and C-reactive protein (CRP) levels in Japanese men. Methods The study included 11,587 men, aged 40-88 years, who underwent a health check-up. Airflow obstruction was defined as a forced expiratory volume in 1 s/forced vital capacity of \70%, and its severity was based on the Global Initiative for Chronic Obstructive Lung Disease guidelines (GOLD). CKD was defined as an estimated glomerular filtration rate of \60 mL/min/1.73 m 2 . Results Airflow obstruction was present in 7.9% of the participants, and 10.6% of the participants had CKD. The average CRP levels were 0.11 ± 0.36, 0.13 ± 0.41, and 0.18 ± 0.41 mg/L for subjects with normal lung function, GOLD stage I, and GOLD stage II-IV, respectively. With regard to CKD, the average CRP levels were 0.11 ± 0.32 and 0.18 ± 0.6 mg/L for subjects without and with CKD, respectively. Analysis of covariance showed no significant differences between the CRP level and lung function status or CKD after age was adjusted for. Logistic regression analysis showed no association among subjects with the three different lung function statuses after age, body mass index, hypertension, diabetes, hyper-low-density-lipoprotein-cholesterolemia, smoking, physical activity, and alcohol intake were controlled for. Conclusions Based on the results of this study, we conclude that there is no interrelationship between CRP level, airflow obstruction, and CKD.

show abstract

Airflow Limitation in Smokers Is Associated with Subclinical Atherosclerosis

Abstract: Smokers with airflow limitation had exaggerated subclinical atherosclerosis. This study suggests that middle-aged men who are susceptible to COPD may also be susceptible to vascular atherosclerosis by smoking, and atherosclerotic change starts early in the disease process of COPD.

Cited by 165 publications

References 42 publications

Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art

Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art

Atherosclerosis is Associated Comorbidity in Patients with Chronic Obstructive Pulmonary Disease: Ultrasound Assessment of Carotid Intima Media Thickness

C-reactive protein levels, airflow obstruction, and chronic kidney disease

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