Airborne‐induced lymphomatoid contact dermatitis caused by methylisothiazolinone

Steenkiste, Edwin; Goossens, An; Meert, Hans; Apers, Sandra; Aerts, Olivier

doi:10.1111/cod.12359

Cited by 22 publications

(17 citation statements)

References 19 publications

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“…In most cases (80%), recovery was achieved with topical steroids and allergen avoidance. Airborne-induced lymphomatoid contact dermatitis caused by methylisothiazolinone has also been reported (6). In accordance with the literature, our patient improved after avoiding the allergen.…”

Section: Discussionsupporting

confidence: 90%

Lymphomatoid contact dermatitis caused by limonene hydroperoxides confirmed by an exposure provocation test with the involved personal hygiene products

et al. 2018

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Section: Discussionsupporting

confidence: 90%

Lymphomatoid contact dermatitis caused by limonene hydroperoxides confirmed by an exposure provocation test with the involved personal hygiene products

et al. 2018

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“…Airborne exposure to isothiazolinone‐containing paints or household detergents is commonly described with intense involvement of the face, behind the ears and the neck . Airborne ACD due to paint exposure has been observed in occupational settings, with the first two cases reported by Lundov et al .…”

Section: Clinical Aspectsmentioning

confidence: 99%

“…43 Airborne exposure to isothiazolinone-containing paints or household detergents is commonly described with intense involvement of the face, behind the ears and the neck. 44 Airborne ACD due to paint exposure has been observed in occupational settings, with the first two cases reported by Lundov et al 45 in 2011. Cases in non-occupational settings were likewise extensively published, [46][47][48] with some patients also reporting respiratory complaints.…”

Section: Clinical Aspectsmentioning

confidence: 99%

Isothiazolinone derivatives and allergic contact dermatitis: a review and update

Herman

Aerts

Montjoye

et al. 2019

Acad Dermatol Venereol

111

115

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Allergic contact dermatitis (ACD) from isothiazolinones has frequently been described in the literature. Following an epidemic of sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in the 1980s, and more recently to MI, the Scientific Committee on Consumer Safety of the European Commission banned their use in leave‐on products, while restricting that in rinse‐off cosmetics. Despite a decreasing prevalence of ACD from MCI/MI and MI, cases caused by occupational exposure and non‐cosmetic isothiazolinone sources are on the rise. Moreover, sensitization to newer and lesser known isothiazolinones has been reported. This paper reviews the epidemiology of contact allergy to different isothiazolinones, clinical presentation of isothiazolinone‐induced ACD, most relevant sensitization sources and potential cross‐reactions between isothiazolinone derivatives. It also provides an update on recent legislative measures.

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“…MI alone has been used as a preservative since 2005 in numerous water‐based products, such as cosmetics and various products for household and industrial applications. It can cause severe and sometimes atypical contact dermatitis . Recent studies have shown an increasing prevalence of MI allergic contact dermatitis; 6.3% in the United States, and between 5% and 13.2% in Europe .…”

Section: Introductionmentioning

confidence: 99%

“…It can cause severe and sometimes atypical contact dermatitis. [1][2][3][4][5][6][7] Recent studies have shown an increasing prevalence of MI allergic contact dermatitis; 6.3% in the United States, 8 and between 5% and 13.2% in Europe. [9][10][11][12] One study from the United Kingdom reported a declining incidence of allergic contact dermatitis (ACD) caused by MI since 2013, 13 whereas another study from Croatia reported an exceptionally high MI contact allergy prevalence of 13.2% among 798 patients tested in 2016, with current relevance in 89.3% of the cases.…”

mentioning

confidence: 99%

Methylisothiazolinone allergic contact dermatitis: Assessment of relapses in 139 patients after avoidance advice

et al. 2019

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Background Methylisothiazolinone (MI) is a preservative that is responsible for an epidemic of allergic contact dermatitis (ACD). Few studies have been published on the prognosis of patients with MI‐induced ACD. Objectives To evaluate relapses of MI‐induced ACD and difficulties in avoiding MI in patients who had received avoidance advice. Methods A retrospective study of patients with MI‐induced ACD diagnosed in two specialized dermato‐allergology units between 2010 and 2015 was performed. The median follow‐up was 3 years. Results Relapses were observed in 64% of 139 included patients, and were severe in 18%. Rinse‐off cosmetics were responsible for the largest proportion of relapses (27%). The median time to relapse was 5 months. Sixty‐nine per cent of relapses were on the hands, and 29% were on the face. Risk factors for relapsing were hand eczema and a personal history of atopy. The main difficulties encountered in the avoidance strategy were hidden sources of MI, the lack of labelling on industrial products, the complexity of cosmetic labelling, and remembering the name of the allergen. Conclusion MI‐induced ACD has a poor prognosis. Its high rate of relapse is mainly attributable to the difficulties of avoidance. Management needs to be improved. Specialized follow‐up in the year following diagnosis is essential to educate patients.

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Airborne‐induced lymphomatoid contact dermatitis caused by methylisothiazolinone

Cited by 22 publications

References 19 publications

Lymphomatoid contact dermatitis caused by limonene hydroperoxides confirmed by an exposure provocation test with the involved personal hygiene products

Lymphomatoid contact dermatitis caused by limonene hydroperoxides confirmed by an exposure provocation test with the involved personal hygiene products

Isothiazolinone derivatives and allergic contact dermatitis: a review and update

Methylisothiazolinone allergic contact dermatitis: Assessment of relapses in 139 patients after avoidance advice

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