Airborne Allergic Contact Dermatitis Caused by Neem Oil

Allergic contact dermatitis caused by neem oil: An underrated allergen?

“…In the last years, few cases of ACD caused by neem oil have been reported; however, considering that neem oil is widely used, the prevalence of allergic reactions might be underestimated. Recently, it was also described as a cause of airborne ACD in a 58‐year‐old man who used a spray containing it as an insect repellent in his garden, and who had previously applied neem oil to treat his psoriasis . Neem oil is widely used because of its antiseptic, anti‐inflammatory, antibacterial and antifungal proprieties, which are attributable to its 100 pharmacologically active constituents; among these, the best known are triterpenes .…”

Neem in Dermatology

“…Airborne allergic contact dermatitis has been reported with the use of neem oil insect repellent in the garden. [ 49 50 ] Allergic contact stomatitis has been reported after the ingestion of neem leaves. [ 51 ] Jadhav reported a case series of lip leukoderma secondary to the use of neem twigs for oral hygiene.…”

Occupational allergic contact dermatitis to neem oil used in natural cosmetic

“…1 Neem oil has been described as an unusual cause of allergic contact dermatitis (ACD) in relation to its use in topical treatments for boils, alopecia areata, dry skin, psoriasis, and atopic dermatitis; as a fungicide, or for uses related to religious practices. [2][3][4][5][6][7] Use of leaves for religious purposes has also been linked to a case of contact stomatitis. 8 Patch testing with the TRUE-Test and the undiluted product provided by the patient "as is" was performed.…”