Allergic contact dermatitis caused by neem oil: An underrated allergen?

Romita, Paolo; Calogiuri, Gianfranco; Bellino, Marco; Prezzo, Serena De; Ambrogio, Francesca; Foti, Caterina

doi:10.1111/cod.13256

Cited by 12 publications

(10 citation statements)

References 12 publications

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“…Despite its internationally widespread use, there are few published cases of ACD due to Neem oil; dermatitis may be underdiagnosed. 9 This case highlights the allergenic potential of natural herbal products and the diagnostic utility of patch tests with the product involved. It also shows that Neem oil is an allergen that should be considered as cause of occupational ACD in cosmetic workers.…”

Section: Discussionmentioning

confidence: 95%

Occupational allergic contact dermatitis to neem oil used in natural cosmetic

et al. 2020

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Section: Discussionmentioning

confidence: 95%

Occupational allergic contact dermatitis to neem oil used in natural cosmetic

et al. 2020

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“…Cholinergic urticaria with sweat allergy is often associated with atopic dermatitis, and a common antigen in these two different diseases has been reported. 5 Omalizumab might have influenced both diseases in this patient. Further observation is needed.…”

mentioning

confidence: 88%

“…Only five cases of allergic contact dermatitis due to neem oil have been reported previously in the published work (Table 1). [1][2][3][4][5] In these cases, neem oil had been used for the treatment of acne, psoriasis, alopecia areata, eczema or dry skin. The duration from the start of use to the onset of eruption was between several days and 2 months, suggesting that the sensitization to neem oil can be established in a short term.…”

Section: Allergic Contact Dermatitis Due To Neem Oil: a Case Report And Mini-reviewmentioning

confidence: 99%

Allergic contact dermatitis due to neem oil: A case report and mini‐review

Tamagawa‐Mineoka

Masuda

Katoh

2019

The Journal of Dermatology

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omalizumab, she was in remission. However, 6 weeks after the last dose, both papular urticaria and hypohidrosis recurred. Restarting omalizumab cleared her symptoms. Her symptoms of atopic dermatitis were also ameliorated with regular use of topical corticosteroids.Cholinergic urticaria is a condition with papular wheals usually induced by heat and often accompanied by sweating disorder.The mechanism of how cholinergic urticaria associates with sweat disorder is not yet clear. There are several hypotheses regarding the pathophysiology of sweat disorder. One of them is that autoimmunity against the eccrine sweat glands causes malfunction of the sweat ducts, which results in sweat leakage into the dermis, followed by an allergic reaction due to the degranulation of mast cells. 1,2 Conventional treatment of cholinergic urticaria with corticosteroid or cyclosporin improved both skin and sweating symptoms in most cases. 3 Omalizumab is a therapeutic monoclonal antibody that neutralizes IgE by binding to the Fce3 domain of IgE. Omalizumab reduces the number of IgE receptors on the cell membrane, which suppresses the release of histamine. Therefore, omalizumab is labeled for the treatment of refractory chronic urticaria and bronchial asthma.Omalizumab has also been used successfully in the treatment of cholinergic urticaria. 4 To the best of our knowledge, this is the first case report of both urticarial papules and hypohidrosis being successfully treated with omalizumab.Patients who have an allergy to antigens against substances in sweat may experience edema by sweat leakage into the dermis. This local edema around the sweat duct may inhibit the flow. Thus, disappearance of wheals may instantly improve the patient's sweating function.Concomitant atopic dermatitis was also improved during omalizumab treatment. Cholinergic urticaria with sweat allergy is often associated with atopic dermatitis, and a common antigen in these two different diseases has been reported. 5 Omalizumab might have influenced both diseases in this patient. Further observation is needed.

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“…Ein 32-jähriger Italiener mit atopischem Ekzem entwickelte eine schwere, nässende ACD im Gesicht, nachdem er eine feuchtigkeitsspendende Gesichtspackung mit Neemöl aufgetragen hatte, sein Epikutantest mit Neemöl 10 % pet. war positiv (bei 10 gesunden Kontrollpersonen negativ) [273]. Neben den gängigen Pflanzen können auch exotischere Blumen und Gewächse ACD bei Gärtnern und Floristen hervorrufen, wie in den Berichten über Eucalyptus spp.…”

Section: Ergebnisseunclassified

Kontaktallergien – Neu aufkommende Allergene und Auswirkungen für das Gesundheitswesen

Uter¹,

Werfel

Lepoittevin

et al. 2021

Kompass Dermatol

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Kontaktallergie (Sensibilisierung) und daraus resultierende allergische Kontaktdermatitis (ACD) sind von erheblicher Tragweite aus Sicht des Gesundheitswesens. Für die vorliegende Übersichtsarbeit hierzu wurden alle passenden Artikel aus dem Zeitraum 2018–2019 per systematischer Suche in Medline und Web of Science<sup>TM</sup> ermittelt; außerdem wurden alle verfügbaren Ausgaben der Fachzeitschriften „Contact Dermatitis“ und „Dermatitis“ manuell durchsucht und so eine frühere, ähnliche Übersichtsarbeit fortgeschrieben und neu fokussiert. Neue Allergene ebenso wie bekannte Allergene, die in neuem Expositionskontext gefunden wurden oder deren Bedeutung in sonstiger Hinsicht neu bewertet wurde, werden in Abschnitten nach Substanzklasse gegliedert beschrieben (z. B. Metalle, Konservierungsmittel, Duftstoffe). Als gemeinsames Ergebnis zahlreicher Untersuchungen fällt sowohl ein Mangel an Informationen über die Produktzusammensetzung auf, z. B. in Bezug auf ein neu beschriebenes Allergen in Leinenturnschuhen (Dimethylthiocarbamylbenzothiazolsulfid), als auch vor allem die mangelnde Kooperativität von Herstellern von Blutzuckermessgeräten bzw. Insulinpumpen. Zu den letztgenannten Geräten hat eine internationale Zusammenarbeit zwischen Dermatologen und Chemikern gezeigt, dass sie bei zahlreichen Diabetikern schwere ACD verursachen, indem sie Isobornylacrylat bzw. N,N’-Dimethylacrylamid freisetzen. Eine verbesserte und vollständige Deklaration der Inhaltsstoffe für Produkte alle Art – und nicht nur, wie wir es derzeit in Europa haben, bei Kosmetika (abgesehen von der vollständigen Auflistung der Duftstoffe) – muss auf die legislative Agenda gesetzt werden.

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Allergic contact dermatitis caused by neem oil: An underrated allergen?

Cited by 12 publications

References 12 publications

Occupational allergic contact dermatitis to neem oil used in natural cosmetic

Occupational allergic contact dermatitis to neem oil used in natural cosmetic

Allergic contact dermatitis due to neem oil: A case report and mini‐review

Kontaktallergien – Neu aufkommende Allergene und Auswirkungen für das Gesundheitswesen

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