Air pollution interacts with past episodes of bronchiolitis in the development of asthma

Kim, B. J.; Seo, Ju Hee; Jung, Young Ho; Kim, H. Y.; Kwon, Ji Won; Kim, H. B.; Lee, S. Y.; Park, K. S.; Yu, Jinho; Kim, H. C.; Leem, Jong-Han; Lee, J. Y.; Sakong, June; Kim, S. Y.; Lee, C. G.; Kang, Dongmug; Ha, Mina; Hong, Yun Chul; Kwon, Ho-Jang; Hong, Soo Jong

doi:10.1111/all.12104

Cited by 39 publications

(28 citation statements)

References 22 publications

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“…They comprised 6 birth cohorts [17][18][19][20][21][22] and 19 population-based longitudinal studies. [12,13,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] Tables 1 and 2 give an overview of the included studies. The reasons for rejecting the remaining 30 papers [9,10, are summarised in Table 3.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of early life factors which adversely affect subsequent lung function

Kouzouna

Gilchrist

Ball

et al. 2016

Paediatric Respiratory Reviews

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It has been known for many years that multiple early life factors can adversely affect lung function and future respiratory health. This is the first systematic review to attempt to analyse all these factors simultaneously. We adhered to strict a priori criteria for inclusion and exclusion of studies.The initial search yielded 29,351 citations of which 208 articles were reviewed in full and 25 were included in the review. This included 6 birth cohorts and 19 longitudinal population studies. The 25 studies reported the effect of 74 childhood factors (on their own or in combinations with other factors) on subsequent lung function reported as percent predicted forced expiration in one second (FEV 1 ). The childhood factors that were associated with a significant reduction in future FEV 1 could be grouped as: early infection, bronchial hyper-reactivity (BHR) / airway lability, a diagnosis of asthma, wheeze, family history of atopy or asthma, respiratory symptoms and prematurity / low birth weight. A complete mathematical model will only be possible if the raw data from all previous studies is made available. This highlights the need for increased cooperation between researchers and the need for international consensus about the outcome measures for future longitudinal studies.

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Section: Resultsmentioning

confidence: 99%

A systematic review of early life factors which adversely affect subsequent lung function

Kouzouna

Gilchrist

Ball

et al. 2016

Paediatric Respiratory Reviews

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“…Air pollution also causes asthma and increases airway hyperresponsiveness 49. Interestingly, it may act synergistically with host susceptibility (as indicated by past episodes of bronchiolitis) to promote the development of asthma 50. Allergic rhinitis is also closely associated with air pollution.…”

Section: Introductionmentioning

confidence: 99%

Environmental Changes, Microbiota, and Allergic Diseases

Kim

Lee

Kim

et al. 2014

Allergy Asthma Immunol Res

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During the last few decades, the prevalence of allergic disease has increased dramatically. The development of allergic diseases has been attributed to complex interactions between environmental factors and genetic factors. Of the many possible environmental factors, most research has focused on the most commonly encountered environmental factors, such as air pollution and environmental microbiota in combination with climate change. There is increasing evidence that such environmental factors play a critical role in the regulation of the immune response that is associated with allergic diseases, especially in genetically susceptible individuals. This review deals with not only these environmental factors and genetic factors but also their interactions in the development of allergic diseases. It will also emphasize the need for early interventions that can prevent the development of allergic diseases in susceptible populations and how these interventions can be identified.

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“…Fourthly, exposure to outdoor pollutants is itself closely associated with the intermediate phenotype of asthma. In children, air pollution interacts with past episodes of bronchiolitis in the development of asthma 54. Moreover, exposure to traffic exhaust particles increases oxidative stress and has epigenetic effects during pregnancy 55.…”

Section: Possible Pathways Linking Prenatal Maternal Distress and Allmentioning

confidence: 99%

Prenatal Maternal Distress and Allergic Diseases in Offspring: Review of Evidence and Possible Pathways

Suh

Chang

Lee

et al. 2017

Allergy Asthma Immunol Res

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Recent studies have suggested a close association between prenatal maternal distress and allergic diseases in the offspring. We selected relevant birth-cohort or national registry studies using a keyword search of the PubMed database and summarized current evidence on the impact of prenatal maternal distress on the development of offspring's allergic diseases. Moreover, we postulated possible pathways linking prenatal distress and allergic diseases based on relevant human and animal studies. Both dysregulated hypothalamic-pituitary-adrenal axis and increased oxidative stress may cause structural (altered brain/lung development) and functional (skewed immune development) changes, which may predispose the fetus to developing allergic diseases during childhood. Although many facts are yet to be discovered, changes in the placental response and epigenetic modification are presumed to mediate the whole process from maternal distress to allergic diseases. Maternal prenatal distress can also interact with other physical or environmental factors, including familial or physical factors, indoor and outdoor pollutants, and early childhood psychological distress. The gut-microbiome-brain axis and the role of the microbiome as an immune modulator should be considered when investigating the stress-allergy relationship and exploring potential intervention modalities. Further research is needed, and particular attention should be given to defining the most vulnerable subjects and critical time periods. To this end, studies exploring relevant biomarkers are warranted, which can enable us to explore adequate intervention strategies.

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Air pollution interacts with past episodes of bronchiolitis in the development of asthma

Abstract: In children, the interaction between air pollution and past episodes of bronchiolitis resulted in a greater prevalence of asthma and pointed to an association with bronchial hyper-reactivity and decreased lung function. These results suggest mechanisms underlying the development of asthma.

Cited by 39 publications

References 22 publications

A systematic review of early life factors which adversely affect subsequent lung function

A systematic review of early life factors which adversely affect subsequent lung function

Environmental Changes, Microbiota, and Allergic Diseases

Prenatal Maternal Distress and Allergic Diseases in Offspring: Review of Evidence and Possible Pathways

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