Air plasma coupled with antibody-conjugated nanoparticles: a new weapon against cancer

Abstract

Ambient air plasmas have been known to kill cancer cells. To enhance selectivity we have used antibody-conjugated nanoparticles. We achieved five times enhancement of melanoma cell death over the case of the plasma alone by using an air plasma with gold nanoparticles bound to anti-FAK antibodies. Our results show that this new interdisciplinary technique has enormous potential for use as a complement to conventional therapies.

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

“…One very promising example of such synergy is cancer therapy. Using antibody-conjugated nanoparticles with cold plasmas led to the five-fold enhancement of melanoma cell death compared to the anticancer efficacy of the plasma treatment alone [45]. The specific mechanisms leading to such a remarkable improvement in the anticancer efficacy are not fully understood.…”

“…While fabrication of plasmas in the fabrication of th atoms of very high concentration the nanoparticles needs to be no loose to avoid being lost on their ratio release oxygen atoms at di diseased tissue is subject to a co 11 based therapies are yet to enjoy a comparably sim r extent of scientific advances [132] and this is ty. Many nanoparticles generate ROS when incu [133], and nanotoxicity represents both a key a Notwithstanding future progress of nanotoxicity m amount of nanoparticles necessary for a target plasma-nanoparticles synergy is particularly bene ry: ussed in Section 3 in which antibody-conjugate ted killing of melanoma cells [45]. It may ha e anticancer properties of both CAPs and and should be taken advantage of to reduce the m ult reduce plasma toxicity.…”

Preferential induction of apoptotic cell death in melanoma cells as compared with normal keratinocytes using a non-thermal plasma torch

“…1 Currently, this type of plasma is the focus of investigations for its potential role in wound healing, 2 tissue incision, 3 protein destruction, cell and tissue modification, 4 bacterial inactivation 5 as well as cancer treatment. 6,7 Non-thermal plasma (NTP) is an ionized gas with electron densities of 10 11 -10 14 (1/cm 3 ) and typical energies of 1-5 (eV). Despite its high energy, NTP exhibits near room temperature characteristics due to the low number density of electrons.…”

A novel cold atmospheric pressure air plasma jet for peri-implantitis treatment: An <i>in vitro</i> study

“…At present, atmospheric pressure cold plasma has demonstrated promising performance in sterilization, blood clotting, skin disease treatment, cancer treatment and oral medicine [12][13][14][15][16][17][18] . In particular, in the area of oral medicine, atmospheric pressure cold plasma has been used for treatment of dental caries, periodontal disease, oral mucosal disease and teeth whitening 19) .…”