Agrimonolide and Desmethylagrimonolide Induced HO-1 Expression in HepG2 Cells through Nrf2-Transduction and p38 Inactivation

Chen, Lei; Teng, Hui; Zhang, Kalin Yanbo; Skalicka-Woźniak, Krystyna; Georgiev, Milen I.; Xiao, Jianbo

doi:10.3389/fphar.2016.00513

Cited by 25 publications

(24 citation statements)

References 60 publications

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“…The available researches confirm that MAPKs are not only one of the important signal pathways of mediating inflammatory reaction, but also involve in the regulation of Nrf2 transcription activity by inducing Nrf2 phosphorylation, although the above-mentioned regulation is only indirect. In different cells, after receiving various stimulation of external or chemical foreign matters, the results of MAPKs regulating Nrf2 may be different [20] , [21] , [22] . Our study showed that IL-1Ra could effectively inhibit MAPKs signal pathway activated by I/R damage, while further activating Nrf2/HO-1 signal pathway.…”

Section: Discussionmentioning

confidence: 99%

The protective role of IL-1Ra on intestinal ischemia reperfusion injury by anti-oxidative stress via Nrf2/HO-1 pathway in rat

Jin

Zhang

et al. 2019

Biomedical Journal

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Background Intestinal ischemia reperfusion injury is a frequent clinical damage, in which the oxidative stress and inflammation play an important role. Interleukin-1 receptor antagonist (IL-1Ra) is a natural anti-inflammatory factor, however, its effect on intestinal ischemia reperfusion injury remains unclear. Methods The rat model of intestinal I/R was induced by occlusion (for 60 min) and reopening (for 60 min) of superior mesenteric artery. The rats were randomly divided into the following 5 groups: sham-operation(S), model (I/R),10 mg/kgIL-1Ra + I/R (C1),20 mg/kgIL-1Ra + I/R (C2), and30 mg/kgIL-1Ra + I/R (C3). Results In this study it was the first time to confirm that IL-1Ra had a significant protection against the intestinal ischemia reperfusion injury. IL-1Ra not only effectively inhibited the expression of inflammatory factors (such as IL-1β, IL-6 and TNF-α) and the activation of neutrophil in intestinal tissues, but also decreased the death of intestinal cells and the damages of intestinal tissues. Interestingly, besides anti-inflammation effect, it was also found that IL-1Ra possessed a significant inhibitory effect on the oxidative stress caused by ischemia/reperfusion injury. Furthermore, the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and hemeoxygenase-1 (HO-1), and the phosphorylation level of Nrf2 were greatly promoted by IL-1Ra. At the same time, IL-1Ra inhibited the mitogen-activated protein kinase (MAPKs) pathway. Conclusion IL-1Ra had the protective effect against intestinal ischemia reperfusion injury, its mechanism included anti-inflammation and anti-oxidative stress in which the Nrf2/HO-1 pathway played an important role. The above-mentioned results may extend the clinical application of IL-1Ra in the treatment of intestinal ischemia reperfusion injury.

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Section: Discussionmentioning

confidence: 99%

The protective role of IL-1Ra on intestinal ischemia reperfusion injury by anti-oxidative stress via Nrf2/HO-1 pathway in rat

Jin

Zhang

et al. 2019

Biomedical Journal

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“…Quercetin was also found to significantly reduce posttranslational levels of Keap1 protein [83]. However, the main bioactive polyphenols, agrimonolide (AM) and desmethylagrimonolide (DM), have been proved to facilitate Keap1 degradation to further accelerate the release of Nrf2 [88].…”

Section: Antioxidant Effects Of Polyphenols On Metsmentioning

confidence: 99%

“…SOD can transform superoxide into H 2 O 2 , and then, H 2 O 2 is catalyzed by CAT and GSH-Px. The Nrf2-ARE pathway was found to activate the endogenous protective system, facilitating antioxidant capacity in cells [88]. Song et al found that anthocyanin supplement upregulated the expressions of SOD and GSH-Px, and subsequently, attenuated lipid peroxidation in the serum, kidney, and liver in an aging mouse model [62].…”

Section: Antioxidant Effects Of Polyphenols On Metsmentioning

confidence: 99%

The Bioprotective Effects of Polyphenols on Metabolic Syndrome against Oxidative Stress: Evidences and Perspectives

Liu

Luo

Wei

2019

Oxidative Medicine and Cellular Longevity

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Polyphenols are the general designation of various kinds of phytochemicals, mainly classified as flavonoids and nonflavonoids. Polyphenolic compounds have been confirmed to exhibit numerous bioactivities and potential health benefits both in vivo and in vitro. Dietary polyphenols have been shown to significantly alleviate several manifestations of metabolic syndrome, namely, central obesity, hypertension, dyslipidemia, and high blood sugar. This review is aimed at discussing the bioprotective effects and related molecular mechanisms of polyphenols, mainly by increasing antioxidant capacity or oxygen scavenging capacity. Polyphenols can exert their antioxidative activity by balancing the organic oxidoreductase enzyme system, regulating antioxidant responsive signaling pathways, and restoring mitochondrial function. These data are helpful for providing new insights into the potential biological effects of polyphenolic compounds and the development of future antioxidant therapeutics.

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“…Anthocyanins are hydrophilic and water-soluble polyphenolic plant pigments and metabolites, which are one of the important antioxidants. They possess a wide range of pharmacological properties, such as antioxidant, antiaging, anti-inflammatory, antimicrobial and anti-cancer [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…The following are available online at http://www.mdpi.com/2073-4360/11/12/2077/ s1,Figure S1: the images of optimized synthesis conditions of Fe3 O 4 /anthocyanin magnetic biocomposite. (a) anthocyanin and Fe 3 O 4 with different mass ratios of 5:1, 1:1, 1:5, 1:10, 1:20, 1:40, 1:80; (b) the optimum synthesis conditions of Fe 3 O 4 /anthocyanin magnetic biocomposite; (c) anthocyanin and Fe 3 O 4 with different mass ratios of 1:25, 1:30, 1:35, 1:40, 1:45, 1:50, 1:55, 1:60, 1:65, 1:70; (d) different reaction times of 2, 4, 6, 8, 10, 12, 14, 16, 18, 22 h; (e) different pH of3, 5, 7, 9, 11, 13; (f) different reaction temperatures of 20, 30, 40, 50, 60 • C, Figure S2: the images of release conditions of anthocyanin.…”

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confidence: 99%

Preparation and pH Controlled Release of Fe3O4/Anthocyanin Magnetic Biocomposites

et al. 2019

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Anthocyanins are a class of antioxidants extracted from plants, with a variety of biochemical and pharmacological properties. However, the wide and effective applications of anthocyanins have been limited by their relatively low stability and bioavailability. In order to expand the application of anthocyanins, Fe 3 O 4 /anthocyanin magnetic biocomposite was fabricated for the storage and release of anthocyanin in this work. The magnetic biocomposite of Fe 3 O 4 magnetic nanoparticle-loaded anthocyanin was prepared through physical intermolecular adsorption or covalent cross-linking. Scanning electron microscopy (SEM), Dynamic light scattering (DLS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and thermal analysis were used to characterize the biocomposite. In addition, the anthocyanin releasing experiments were performed. The optimized condition for the Fe 3 O 4 /anthocyanin magnetic biocomposite preparation was determined to be at 60 • C for 20 h in weak alkaline solution. The smooth surface of biocomposite from SEM suggested that anthocyanin was coated on the surface of the Fe 3 O 4 particles successfully. The average size of the Fe 3 O 4 /anthocyanin magnetic biocomposite was about 222 nm. Under acidic conditions, the magnetic biocomposite solids could be repeatable released anthocyanin, with the same chemical structure as the anthocyanin before compounding. Therefore, anthocyanin can be effectively adsorbed and released by this magnetic biocomposite. Overall, this work shows that Fe 3 O 4 /anthocyanin magnetic biocomposite has great potential for future applications as a drug storage and delivery nanoplatform that is adaptable to medical, food and sensing.

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Agrimonolide and Desmethylagrimonolide Induced HO-1 Expression in HepG2 Cells through Nrf2-Transduction and p38 Inactivation

Cited by 25 publications

References 60 publications

The protective role of IL-1Ra on intestinal ischemia reperfusion injury by anti-oxidative stress via Nrf2/HO-1 pathway in rat

The protective role of IL-1Ra on intestinal ischemia reperfusion injury by anti-oxidative stress via Nrf2/HO-1 pathway in rat

The Bioprotective Effects of Polyphenols on Metabolic Syndrome against Oxidative Stress: Evidences and Perspectives

Preparation and pH Controlled Release of Fe3O4/Anthocyanin Magnetic Biocomposites

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