Agricultural Hygiene

Popendorf, William; Donham, Kelley J.

doi:10.1002/0471435139.hyg060.pub2

Cited by 3 publications

(3 citation statements)

References 242 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, further evaluation of registered pesticides is warranted. Key words Agricultural health study, Cancer, Pesticides, Review Agricultural workers are exposed to a variety of chemical, physical, and biological hazards in the process of cultivating and harvesting crops and/ or raising livestock (Litchfield 1999;Popendorf and Donham 1991;Shaver and Tong 1991;White and Cessna 1989). In addition to pesticides, occupational exposure to solvents, metals, engine exhaust, welding fumes, and grain dusts are prevalent in agriculture (Coble et al 2002;Shaver and Tong 1991).…”

Section: A Review Of Pesticide Exposure and Cancer Incidence In The Amentioning

confidence: 99%

A review of pesticide exposure and cancer incidence in the agricultural health study cohort

Weichenthal¹,

Moase²,

Chan³

2012

Ciênc. saúde coletiva

View full text Add to dashboard Cite

Revisão sobre a exposição aos pesticidas e a incidência de câncer em estudo de coorte da saúde dos agricultoresResumo Nós revisamos evidências epidemioló-gicas relacionadas à exposição ocupacional a pesticidas e à incidência de câncer no Estudo da Saú-de Agrícola (AHS). Descobertas relacionadas com a vida-dia e / ou intensidade do tempo de vidadia do uso de agrotóxicos são o foco principal desta revisão, porque estas medidas permitem a avaliação do potencial das relações de exposição-resposta. A maioria dos 32 pesticidas examinados não foram fortemente associados à incidência de cân-cer em aplicadores de pesticidas. Um aumento da taxa e padrões de resposta-exposição positivos foram reportados em 12 pesticidas registrados atualmente nos Estados Unidos e Canadá. A classificação de exposição incorreta também é uma preocupação para o AHS e pode limitar a análise dos padrões de resposta-exposição. É necessário um acompanhamento contínuo para clarificar as associações reportadas até hoje. Em particular, é necessária uma avaliação mais profunda dos pesticidas registrados. Palavras-chave Estudo de saúde agrícola, Cân-cer, Pesticidas, Revisão Abstract We reviewed epidemiologic evidence related to occupational pesticide exposures and cancer incidence in the Agricultural Health Study (AHS) cohort. Studies were identified from the AHS publication list available on a Medline/ PubMed database search in March 2009. Findings related to lifetime-days and/or intensityweighted lifetime-days of pesticide use are the primary focus of this review, because these measures allow for the evaluation of potential exposure-response relationships. Most of the 32 pesticides examined were not strongly associated with cancer incidence in pesticide applicators. Increased rate ratios and positive exposure-response patterns were reported for 12 pesticides currently registered in Canada and/or the United States. Exposure misclassification is also a concern in the AHS and may limit the analysis of exposureresponse patterns. Epidemiologic evidence outside the AHS remains limited with respect to most of the observed associations, but animal toxicity data support the biological plausibility of relationships observed six pesticides. Continued follow-up is needed to clarify associations reported to date. In particular, further evaluation of registered pesticides is warranted.

show abstract

Section: A Review Of Pesticide Exposure and Cancer Incidence In The Amentioning

confidence: 99%

A review of pesticide exposure and cancer incidence in the agricultural health study cohort

Weichenthal¹,

Moase²,

Chan³

2012

Ciênc. saúde coletiva

View full text Add to dashboard Cite

show abstract

“…This, in turn, results in an increase in pesticide use. In order to meet food demand and to increase efficiency, agricultural producers tend to use chemicals excessively (Coble et al, 2002; Litchfield, 1999; Popendorf and Donham, 1991; Shaver and Tong, 1991).…”

Section: Introductionmentioning

confidence: 99%

The effects of resveratrol against trifluralin toxicity in the urinary tract of rats

et al. 2013

View full text Add to dashboard Cite

The herbicide itself and the degradation products are highly toxic on biological systems. The aim of this study is to investigate the potential toxic effects of trifluralin (TRF) on the urinary system of male rats and to investigate the protective effects of resveratrol (RSV) in TRF-induced urinary system damage. A total of 35 male Wistar rats were randomly divided into: (1) control group, (2) sham group, (3) low dose TRF group (0.8 g/kg/day), (4) high dose TRF group (2 g/kg/day) and (5) high dose TRF + RSV group 10 mg/kg/day. RSV was administered for 21 days by intragastric gavage at a dose of 10 mg/kg/day after induction of TRF. Kidney, ureter and urinary bladder tissue was examined using light microscopy and ultrastructurally. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling was performed to detect apoptosis. Superoxide dismutase (SOD), glutathion peroxidase (GPx) and malondialdehyde (MDA) levels were also evaluated biochemically for oxidative stress parameters. Histological evaluation showed that TRF increases apoptosis and oxidative stress, causes histological tissue damages and biochemical changes in the kidneys but does not cause any damage to the ureter and bladder. Treatment with RSV significantly attenuated tissue damage in the urinary system of rats. Apopitotic cells were significantly decreased in the treatment group. Additionally, treatment with RSV decreased SOD and GPx levels and increased MDA levels in the kidney tissue of animals subjected to TRF. These results show that RSV can significantly minimize histological damage and biochemical differences in treating TRF-induced kidney injury in rats.

show abstract

“…Agricultural workers are exposed to a variety of chemical, physical, and biological hazards in the process of cultivating and harvesting crops and/or raising livestock ( Litchfield 1999 ; Popendorf and Donham 1991 ; Shaver and Tong 1991 ; White and Cessna 1989 ). In addition to pesticides, occupational exposure to solvents, metals, engine exhaust, welding fumes, and grain dusts are prevalent in agriculture ( Coble et al 2002 ; Shaver and Tong 1991 ).…”

mentioning

confidence: 99%

A Review of Pesticide Exposure and Cancer Incidence in the Agricultural Health Study Cohort

Weichenthal

Moase

Chan

2010

Environ Health Perspect

212

View full text Add to dashboard Cite

ObjectiveWe reviewed epidemiologic evidence related to occupational pesticide exposures and cancer incidence in the Agricultural Health Study (AHS) cohort.Data sourcesStudies were identified from the AHS publication list available at http://aghealth.nci.nih.gov as well as through a Medline/PubMed database search in March 2009. We also examined citation lists. Findings related to lifetime-days and/or intensity-weighted lifetime-days of pesticide use are the primary focus of this review, because these measures allow for the evaluation of potential exposure–response relationships.Data synthesisWe reviewed 28 studies; most of the 32 pesticides examined were not strongly associated with cancer incidence in pesticide applicators. Increased rate ratios (or odds ratios) and positive exposure–response patterns were reported for 12 pesticides currently registered in Canada and/or the United States (alachlor, aldicarb, carbaryl, chlorpyrifos, diazinon, dicamba, S-ethyl-N,N-dipropylthiocarbamate, imazethapyr, metolachlor, pendimethalin, permethrin, trifluralin). However, estimates of association for specific cancers were often imprecise because of small numbers of exposed cases, and clear monotonic exposure–response patterns were not always apparent. Exposure misclassification is also a concern in the AHS and may limit the analysis of exposure–response patterns. Epidemiologic evidence outside the AHS remains limited with respect to most of the observed associations, but animal toxicity data support the biological plausibility of relationships observed for alachlor, carbaryl, metolachlor, pendimethalin, permethrin, and trifluralin.ConclusionsContinued follow-up is needed to clarify associations reported to date. In particular, further evaluation of registered pesticides is warranted.

show abstract

Agricultural Hygiene

Cited by 3 publications

References 242 publications

A review of pesticide exposure and cancer incidence in the agricultural health study cohort

A review of pesticide exposure and cancer incidence in the agricultural health study cohort

The effects of resveratrol against trifluralin toxicity in the urinary tract of rats

A Review of Pesticide Exposure and Cancer Incidence in the Agricultural Health Study Cohort

Contact Info

Product

Resources

About