A Review of Pesticide Exposure and Cancer Incidence in the Agricultural Health Study Cohort

Weichenthal, Scott; Moase, Connie; Chan, P.K.L.

doi:10.1289/ehp.0901731

Cited by 211 publications

(103 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Une étude s'intéressant à de nombreuses expositions professionnelles a montré qu'une exposition aux pesticides était associée à la survenue de CCB, mais seulement si elle était très importante ; cette étude ne précisait pas les types de pesticides incriminés [17]. L'exposition aux pesticides a été mise en cause dans d'autres cancers, comme le cancer de la prostate et le cancer du sein où ces pesticides interviendraient notamment en perturbant les mécanismes endocriniens ; il y a peu d'études sur le sujet et les résultats sont contradictoires [54].…”

Section: Discussionunclassified

Revue systématique des facteurs de risque modifiables des cancers de la muqueuse buccale

Arrivé

Ligier

Trouillet³

et al. 2012

Med Buccale Chir Buccale

View full text Add to dashboard Cite

Résumé -Les cancers de la cavité buccale (CCB) et des lèvres occupaient, en 2008, le 16 ème rang des cancers dans le monde. Les principaux facteurs de risque connus de ces cancers sont le tabac et l'alcool mais il existe d'autres facteurs pouvant être ciblés dans le cadre d'une prévention primaire. L'objectif de cette étude était d'identifier les facteurs de risque évitables et les facteurs protecteurs des cancers de la muqueuse buccale à travers une revue systématique de la littérature scientifique récente. Les mots clés indexés dans le MeSH « risk factors » et « mouth neoplasms » ont été appliqués dans la base de données PubMed. Les articles publiés entre le 01/01/2005 et le 01/01/2011 en anglais et en français ont été retenus s'ils traitaient de CCB et d'un ou de plusieurs facteurs de risque. Les articles s'intéressant exclusivement aux cancers des glandes salivaires ou aux facteurs de risque génétiques, de même que les articles rapportant des études transversales ou de qualité insuffisante, ont été exclus. Sur 325 références, 32 ont été retenues : 19 études cas-témoins, 8 cohortes prospectives et 5 méta-analyses ; 2 études concernaient uniquement le cancer des lèvres. Les principaux facteurs de risque mis en évidence étaient la consommation d'alcool et de tabac et leur effet synergique. Des facteurs génétiques, comme le polymorphisme du gène codant pour l'alcool déshydrogénase ont été identifiés comme cofacteurs. Le HPV 16 impliqué dans la survenue du cancer du col de l'utérus pourrait avoir un rôle oncogène sur la muqueuse buccale. Des études ont identifié des facteurs locaux (traumatisme, mauvaise hygiéne…) mais elles ne sont pas apparues suffisamment fiables méthodologiquement pour pouvoir s'appuyer sur leurs conclusions. L'exposition aux ultra-violets a été mise en cause dans la survenue du cancer des lèvres, principalement chez les sujets transplantés. Une association entre CCB et exposition professionnelle importante aux pesticides et à certains solvants a également été retrouvée. Au contraire, une alimentation riche en fruits et légumes frais, la consommation de café et les visites régulières chez le chirurgien-dentiste étaient associées à une diminution du risque de CCB. Les CCB sont accessibles à une prévention primaire, axée aujourd'hui en France sur la lutte contre le tabagisme et la consommation d'alcool, qui s'intègre dans une démarche de santé publique plus globale car ces facteurs de risque sont communs à d'autres cancers et à d'autres maladies chroniques fréquentes. Dans cette logique, le programme de vaccination contre le HPV impliqué dans le cancer du col de l'utérus et le Programme National Nutrition Santé auront peut-être un effet favorable sur l'incidence des CCB. En ce qui concerne la prévention secondaire, le dépistage des lésions précancéreuses ou de lésions invasives à un stade précoce fait l'objet de mesures dans le Plan cancer gouvernemental 2009-2013.Abstract -Modifiable risk factors for mucous oral cancers: a systematic review. Cancers of oral cavity and lips were, in 2008, the 1...

show abstract

Section: Discussionunclassified

Revue systématique des facteurs de risque modifiables des cancers de la muqueuse buccale

Arrivé

Ligier

Trouillet³

et al. 2012

Med Buccale Chir Buccale

View full text Add to dashboard Cite

show abstract

“…35,36 Additional support for a causal link between pesticide exposure and childhood leukemia comes from adult studies, such as the Agricultural Health Study, a prospective cohort of pesticide applicators, reporting increased risks of hematopoietic tumors, including leukemia, with 12 agricultural pesticides registered in the United States/Canada. 37 Preliminary Agricultural Health Study analyses also suggested an overall increase of cancers in the offspring of fathers exposed to 3 out of the 16 pesticides evaluated, an observation that will be important to reproduce. 38 Several pesticides commonly used in and around residences have been classified as possible human carcinogens (eg, tetramethrin, piperonyl butoxide, trifluralin) or probable/likely human carcinogens (eg, propoxur, permethrin, carbaryl).…”

Section: Pesticidesmentioning

confidence: 97%

Childhood Leukemia: A Preventable Disease

et al. 2016

View full text Add to dashboard Cite

In contrast to most pediatric cancers, there is a growing body of literature, nationally and internationally, that has implicated the role of several environmental indoor and outdoor hazards in the etiology of childhood leukemia. For example, exposures to solvents, traffic, pesticides, and tobacco smoke have consistently demonstrated positive associations with the risk of developing childhood leukemia. Intake of vitamins and folate supplementation during the preconception period or pregnancy has been demonstrated to have a protective effect. Despite the strength of these findings, the dissemination of this knowledge to clinicians has been limited. Some children may be more vulnerable than others as documented by the high and increasing incidence of childhood leukemia in Hispanics. To protect children’s health, it is prudent to establish programs to alter exposure to those factors with well-established associations with leukemia risk rather than to suspend judgment until no uncertainty remains. This is particularly true because other serious health outcomes (both negative and positive) have been associated with the same exposures. We draw from historical examples to put in perspective the arguments of association versus causation, as well as to discuss benefits versus risks of immediate and long-term preventive actions.

show abstract

“…1,3 Toxic effects on humans, such as acute neurological toxicity, impairment of neurological development, possible dysfunction of the immune, reproductive and endocrine systems, cancers, chronic kidney disease and other potential diseases have been reported in many papers. 4,5 PPCPs are used to prevent or treat human and animal diseases or to improve the quality of daily life. They have emerged as a major group of environmental pollutants over the past decades since some of them are produced and used in large quantities.…”

Section: Introductionmentioning

confidence: 99%

Multi-Residue Method for Determination of Thirty-Five Pesticides, Pharmaceuticals and Personal Care Products in Water Using Ionic Liquid-Dispersive Liquid-Liquid Microextraction Combined with Liquid Chromatography-Tandem Mass Spectrometry

Marube¹,

Caldas²,

Santos³

et al. 2017

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Ionic liquid-dispersive liquid-liquid microextraction (IL-DLLME) was used for the determination of different chemical classes of analytes for the first time. Limits of quantification (LOQs) ranged from 0.5 to 2.5 µg L −1, and the linearity ranged from the LOQ of each compound to 50 µg L -1. Recoveries ranged from 70 to 120% for the compounds, with relative standard deviations less than 18%. The proposed method demonstrates for the first time that sample preparation by IL-DLLME and determination by liquid chromatography-tandem mass spectrometry (LC-MS/MS) can be used successfully for the simultaneous extraction of 19 kinds of pesticides and 16 PPCPs from water samples. In addition, to eliminate the environmental risk of waste solvent disposal, this technique uses a low-toxicity extraction solvent. Finally, the analytical method proposed was applied successfully in analysis in surface water samples. Keywords: IL-DLLME, water, pesticides, PPCPs, LC-MS/MS IntroductionIn recent decades, many synthetic organic compounds detected in water samples have attracted people's attention. Pesticides, pharmaceuticals and personal care products (PPCPs) 1 have also been detected and are investigation targets. 2 Pesticides play an important role in increasing agricultural productivity. Their use in agriculture is inevitable, still being the most effective tool in the fight against weeds and pests. They are not only used for agricultural purposes, but also in forest and environmental preservation areas. Although the use of pesticides in agricultural applications provides a wide range of beneficial effects, their extensive use has been a concern because of hazards to the environment. 1,3 Toxic effects on humans, such as acute neurological toxicity, impairment of neurological development, possible dysfunction of the immune, reproductive and endocrine systems, cancers, chronic kidney disease and other potential diseases have been reported in many papers. 4,5 PPCPs are used to prevent or treat human and animal diseases or to improve the quality of daily life. They have emerged as a major group of environmental pollutants over the past decades since some of them are produced and used in large quantities. 2 Various investigations indicate that many of them can hardly be totally removed during the water treatment process. Many PPCPs are persistent or pseudo-persistent in the environment and are toxic to non-target organisms. They also have the potential to bioaccumulate in different trophic level organisms. 2,6 To quantitatively evaluate the fate of these chemicals and ensure the quality of drinking water, effective analytical methods are extremely necessary. Since the concentrations of pesticides and PPCPs in water are generally very low (ng L -1 or less), extraction techniques are needed prior to chromatographic determination. 7 The most commonly used methods are liquid-liquid extraction (LLE), 8,9 and solid phase extraction (SPE).10,11 These techniques, however, are time consuming and use large amounts of organic solvents. Thus, the ...

show abstract

A Review of Pesticide Exposure and Cancer Incidence in the Agricultural Health Study Cohort

Cited by 211 publications

References 89 publications

Revue systématique des facteurs de risque modifiables des cancers de la muqueuse buccale

Revue systématique des facteurs de risque modifiables des cancers de la muqueuse buccale

Childhood Leukemia: A Preventable Disease

Multi-Residue Method for Determination of Thirty-Five Pesticides, Pharmaceuticals and Personal Care Products in Water Using Ionic Liquid-Dispersive Liquid-Liquid Microextraction Combined with Liquid Chromatography-Tandem Mass Spectrometry

Contact Info

Product

Resources

About