Aging in HIV-Infected Subjects: A New Scenario and a New View

Negredo, Eugènia; Back, David; Blanco, José Ramón; Blanco, Julià; Erlandson, Kristine M.; Garolera, Maite; Guaraldi, Giovanni; Mallon, Patrick; Moltó, José; Serra, José Antonio; Clotet, Bonaventura

doi:10.1155/2017/5897298

Cited by 58 publications

(42 citation statements)

References 82 publications

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“…HIV‐1 infection occurs worldwide, affecting nearly 36 million people and 1 million in the United States alone. Improvements to highly active antiretroviral therapy (HAART) has resulted in an aging HIV‐infected population, and at the current rate, the proportion of HIV‐infected individuals 50 years old or higher will reach 73% by 2030 (Negredo et al, ). Intriguingly, the HIV‐infected population suffer from a variety of ailments experienced in the elderly; therefore, patients are sometimes described as undergoing accelerated aging (Guaraldi et al, ).…”

Section: Neurodegenerative Disease and Astrocyte Senescencementioning

confidence: 99%

Astrocyte senescence: Evidence and significance

2019

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Astrocytes participate in numerous aspects of central nervous system (CNS) physiology ranging from ion balance to metabolism, and disruption of their physiological roles can therefore be a contributor to CNS dysfunction and pathology. Cellular senescence, one of the mechanisms of aging, has been proposed as a central component of the age dependency of neurodegenerative disorders. Cumulative evidence supports an integral role of astrocytes in the initiation and progression of neurodegenerative disease and cognitive decline with aging. The loss of astrocyte function or the gain of neuroinflammatory function as a result of cellular senescence could have profound implications for the aging brain and neurodegenerative disorders, and we propose the term “astrosenescence” to describe this phenotype. This review summarizes the current evidence pertaining to astrocyte senescence from early evidence, in vitro characterization and relationship to age‐related neurodegenerative disease. We discuss the significance of targeting senescent astrocytes as a novel approach toward therapies for age‐associated neurodegenerative disease.

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Section: Neurodegenerative Disease and Astrocyte Senescencementioning

confidence: 99%

Astrocyte senescence: Evidence and significance

2019

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“…Morbidity and mortality in persons living and aging with HIV is now primarily due to non-HIV/ AIDS related causes, including cardiovascular diseases (CVD) such as cardiomyopathy and coronary artery disease. 62,63 Persons living with HIV (PLWH) in the United States, who are disproportionately represented by racial and sexual/gender minorities, have higher incidence of hyperlipidemia, hypertension, and metabolic abnormalities than the general population. [64][65][66] Accordingly, care for PLWH has shifted to detection, prevention, and treatment of these comorbidities.…”

Section: Scaling Out Known Ebis For Cvd To People Living With Hivmentioning

confidence: 99%

Implementation Research Methodologies for Achieving Scientific Equity and Health Equity

et al. 2019

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Implementation science has great potential to improve the health of communities and individuals who are not achieving health equity. However, implementation science can exacerbate health disparities if its use is biased toward entities that already have the highest capacities for delivering evidence-based interventions. In this article, we examine several methodologic approaches for conducting implementation research to advance equity both in our understanding of what historically disadvantaged populations would need—what we call scientific equity—and how this knowledge can be applied to produce health equity. We focus on rapid ways to gain knowledge on how to engage, design research, act, share, and sustain successes in partnership with communities. We begin by describing a principle-driven partnership process between community members and implementation researchers to overcome disparities. We then review three innovative implementation method paradigms to improve scientific and health equity and provide examples of each. The first paradigm involves making efficient use of existing data by applying epidemiologic and simulation modeling to understand what drives disparities and how they can be overcome. The second paradigm involves designing new research studies that include, but do not focus exclusively on, populations experiencing disparities in health domains such as cardiovascular disease and co-occurring mental health conditions. The third paradigm involves implementation research that focuses exclusively on populations who have experienced high levels of disparities. To date, our scientific enterprise has invested disproportionately in research that fails to eliminate health disparities. The implementation research methods discussed here hold promise for overcoming barriers and achieving health equity.Ethn Dis. 2019;29(Suppl 1):83-92; doi:10.18865/ed.29.S1.83.

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“…There is increasing evidence that the prevalence of comorbidities and risk factors for chronic diseases are very common in HIV patients aged 50 years or older and increase with age. Moreover, it is higher in the HIVinfected population when compared to uninfected individuals (1,6) .…”

Section: Introductionmentioning

confidence: 96%

Social representations of the elderly about HIV/AIDS

et al. 2019

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Objective: to understand the representational content about HIV/AIDS among seropositive elderly people. Method: a qualitative study carried out from April to May 2017, in the city of Recife/PE, with 48 seropositive elderly people, through a semi-structured interview. The Social Representations Theory was used as theoretical framework and the method of lexical analysis through IRAMUTEQ software. Results: it was observed that the social representation of HIV is structured around the proximity of death and that it is a disease of restricted groups, leading to feelings of sadness. On the other hand, it is evident a transformation of the representation linked to the reified knowledge, leading to the process of naturalization of the disease. Final considerations: it is concluded that the elderly living with HIV, when they undergo a process of reframing about the disease, become more flexible to deal with their condition of seropositivity.

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Aging in HIV-Infected Subjects: A New Scenario and a New View

Cited by 58 publications

References 82 publications

Astrocyte senescence: Evidence and significance

Astrocyte senescence: Evidence and significance

Implementation Research Methodologies for Achieving Scientific Equity and Health Equity

Social representations of the elderly about HIV/AIDS

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