Aging, Hypertension, and Renal Damage: Generalities and Results of the Cardiovascular Study in the Elderly

Pessina, Achille C.; Casíglia, Edoardo; Palù, C. Dal

doi:10.1016/s0272-6386(12)70249-4

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…We have found three studies [11,12,19] among many others [14,[20][21][22][23][24][25] three share in common large data sets, above 100 subjects, and sufficient information is presented so that we can calculate clearances to the common metric of our ratios for a direct comparison. For each of the three published studies, we calculated the mean clearance for each decade between 20 and 90 years of age.…”

Section: Comparison To Prior Studiesmentioning

confidence: 99%

Causes and consequences of kidney loss in patients with nephrolithiasis

Worcester

Parks

Josephson

et al. 2003

Kidney International

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Section: Comparison To Prior Studiesmentioning

confidence: 99%

Causes and consequences of kidney loss in patients with nephrolithiasis

Worcester

Parks

Josephson

et al. 2003

Kidney International

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“…There is no doubt that elevated blood pressure must be treated in the elderly, since it is associated with higher cardiovascular morbidity and mortality, with renal failure being only one reflection of target organ damage [91,92]. In the past there has been considerable discussion whether the risk of antihypertensive treatment in the elderly outweighs its benefit.…”

Section: Treatment Of Hypertension In the Elderly: Whom To Treat And mentioning

confidence: 99%

“…After several major controlled trials on antihypertensive treatment in the elderly, there can be no more doubt that antihypertensive treatment achieves a significant reduction in cardiovascular morbidity and mortality in elderly patients with essential hypertension up to the age of at least 80 years [93][94][95][96][97][98][99]. In parallel, effective control of hypertension in the elderly retards the decrease in renal function associated with age [91]. Metaanalysis of several controlled trials has revealed that only about 40 elderly subjects must be treated for 5 years to prevent one stroke and about 60 must be treated to prevent one myocardial infarction [100,101].…”

Section: Treatment Of Hypertension In the Elderly: Whom To Treat And mentioning

confidence: 99%

Relationship between Hypertension and Renal Function and Its Therapeutic Implications in the Elderly

Fliser¹,

Ritz²

1998

Gerontology

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The kidney is an important target of hypertension-induced organ damage. Recent long-term observation studies have documented that in individuals, without primary chronic renal disease, a very significant relationship exists between hypertension and impaired renal function, elderly hypertensives having a particularly worse prognosis. The hallmark of hypertensive renal injury is thought to be a progressive increase in intrarenal vascular resistance. The alterations in renal hemodynamics are accentuated in elderly patients with essential hypertension, pointing to a greater vulnerability of the senescent kidney to superimposed injury such as high blood pressure. Treatment of elevated blood pressure in the elderly therefore not only reduces cardiovascular morbidity and mortality, but also reduces the incidence of renal failure as a consequence of hypertension-induced damage.

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Casíglia

Zanette

Mazza

et al. 2000

European Journal of Epidemiology

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Although non-insulin-dependent diabetes mellitus (NIDDM) is considered a major cause of death, the role of some independent risk factors in diabetic patients is under debate. In fact the prognosis of NIDDM diabetes varies considerably in relation to the individual risk pattern, and the different studies are not directly comparable because of differences in size, age and geography of the samples, and type of statistical analysis. The aim of the study is to identify the independent predictors of mortality in a cohort of subjects with NIDDM, and to verify whether the relative risk (RR) of cardiovascular mortality is different in comparison to that of coeval non-diabetic subjects from a general population. The study includes 683 patients with NIDDM from the Northern Italian town of Pordenone, followed up for 6 years and age- and sex-matched to 683 non-diabetic subjects from a Northern Italian general population. When the two cohorts were compared, NIDDM turned out to be a strong risk factor for cardiovascular mortality (RR: 2.67). Age, coronary artery disease (RR: 1.78), arterial hypertension (RR: 1.39), macro- (RR: 2.97) and microalbuminuria (RR: 2.01) were independent predictors of cardiovascular mortality in the diabetics. In conclusion, survival of diabetic patients is worse than that of non-diabetic coeval subjects. Only few items are able to predict cardiovascular mortality in the diabetics, namely age, hypertension, CAD, macro- and microalbuminuria.

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Aging, Hypertension, and Renal Damage: Generalities and Results of the Cardiovascular Study in the Elderly

Cited by 6 publications

References 16 publications

Causes and consequences of kidney loss in patients with nephrolithiasis

Causes and consequences of kidney loss in patients with nephrolithiasis

Relationship between Hypertension and Renal Function and Its Therapeutic Implications in the Elderly

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