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Abstract

Although non-insulin-dependent diabetes mellitus (NIDDM) is considered a major cause of death, the role of some independent risk factors in diabetic patients is under debate. In fact the prognosis of NIDDM diabetes varies considerably in relation to the individual risk pattern, and the different studies are not directly comparable because of differences in size, age and geography of the samples, and type of statistical analysis. The aim of the study is to identify the independent predictors of mortality in a cohort of subjects with NIDDM, and to verify whether the relative risk (RR) of cardiovascular mortality is different in comparison to that of coeval non-diabetic subjects from a general population. The study includes 683 patients with NIDDM from the Northern Italian town of Pordenone, followed up for 6 years and age- and sex-matched to 683 non-diabetic subjects from a Northern Italian general population. When the two cohorts were compared, NIDDM turned out to be a strong risk factor for cardiovascular mortality (RR: 2.67). Age, coronary artery disease (RR: 1.78), arterial hypertension (RR: 1.39), macro- (RR: 2.97) and microalbuminuria (RR: 2.01) were independent predictors of cardiovascular mortality in the diabetics. In conclusion, survival of diabetic patients is worse than that of non-diabetic coeval subjects. Only few items are able to predict cardiovascular mortality in the diabetics, namely age, hypertension, CAD, macro- and microalbuminuria.

The Prevalence of Uncontrolled Hypertension among Patients Taking Antihypertensive Medications and the Associated Risk Factors in North Palestine: A Cross-Sectional Study

“…Patients who have both HTN and diabetes mellitus are at a higher risk of experiencing cardiovascular events compared to nondiabetic HTN patients [ 21 ]. We found that diabetic patients with HTN demonstrated remarkably poor BP control ( P =0.010).…”

Shadow of diabetes over cardiovascular disease: comparative quantification of population-attributable all-cause and cardiovascular mortality

“…While there is no doubt that diabetes harbors a causal effect on CVD [34-38] and all-cause mortality [36,39,40], whether these effects are exerted through hyperglycemia or whether it is just an innocent bystander has been increasingly challenged [41-43]. Overt diabetes has been shown to modify the effect on mortality of hyperglycemia [44].…”

Nefrokardial'nyy sindrom pri sakharnom diabete

“…В 6-летнем исследовании, проведенном в Италии и включавшем 683 пациента с СД 2, микро-и макроальбуми нурия оказались независимыми факторами риска сердеч но-сосудистой летальности. ЭАМ в диапазоне микро-или макроальбуминурии повышала относительный риск кардиоваскулярной смерти в 2 и 3 раза соответственно [14]. Дру гое проспективное исследование (п=939).…”