Aggregation and interactional behavior of cationic surfactants in the presence of cephalosporin drug: A thermo-acoustic and spectroscopic approach

Pathania, Lalita; Chauhan, Suvarcha

doi:10.1016/j.molliq.2019.112210

Cited by 18 publications

(14 citation statements)

References 58 publications

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“…The results showed that the cmc value of the IMP + TX-100 system reduced when the α 1 of TX-100 enhanced in the solution. As specified in the literature, amphiphilic drug and surfactant mixtures formed mixed micelles via interaction through each other [33,38]. Here, the resulting cmc value of the mixtures showed that mixed micelle formation occurred at inferior concentrations due to the diminution in electrostatic repulsion among the constituent molecules in each used media variation.…”

Section: Cmc and Ideal Cmc (Cmc Id ) Values In Various Mediasupporting

confidence: 56%

Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study

et al. 2021

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In this paper, the interaction of imipramine hydrochloride (IMP, antidepressant drug) and a non-ionic surfactant Triton X-100 (TX-100) mixture in five different ratios through the tensiometric method in different solvents (aqueous/0.050 mol·kg−1 aqueous NaCl/0.250 mol·kg−1 aqueous urea (U)) were examined thoroughly at a temperature of 298 K. UV–Visible studies in an aqueous system of IMP + TX-100 mixtures were also investigated and discussed in detail. The pure (IMP and TX-100) along with the mixtures’ critical micelle concentration (cmc) were assessed by a tensiometric technique. The obtained deviation of the mixtures’ cmc values from their ideal values revealed the nonideal behavior of IMP + TX-100 mixtures amongst IMP and TX-100. Compared to aqueous systems, in the presence of aqueous NaCl, several changes in micelles/mixed micelles occurred, and hence a synergism/attractive interaction amongst components was found increased while in the existence of U, the synergism/attractive interaction between them decreased. The evaluated interaction parameter (βRb) value of mixed micelles showed the attractive or synergism between the IMP and TX-100. Various evaluated thermodynamic parameters in an aqueous system showed that the mixed micellization of the IMP + TX-100 mixture was an entropically spontaneous phenomenon, although the existence of salt in all studied systems can somewhat increase the spontaneity of the micellization process and in the aqueous U system, the spontaneity of the micellization process decreased. In an aqueous system, the interaction between IMP and TX-100 was also confirmed by UV–Visible study.

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Section: Cmc and Ideal Cmc (Cmc Id ) Values In Various Mediasupporting

confidence: 56%

Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study

et al. 2021

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“…The CMC values of surfactant also show decrease with increase in the length of alkyl chain (Et 4 N + Br − > Pr 4 N + Br − > Bu 4 N + Br − ). Also, the hydrophobic backbone of CTAB is responsible for the effect of R 4 N + Br − in lowering the CMC of CTAB, implying that the hydrophobic interaction is more prevalent in the aggregation behavior (Chauhan et al, 2014; Chauhan & Kaur, 2017; Pathania & Chauhan, 2020a).…”

Section: Resultsmentioning

confidence: 99%

“…Their self‐assembling property makes them to be utilized in different fields like membrane mimetic medium, drug delivery, flow field regulators, pharmaceutical formulations, and separations (Schramm et al, 2003). These amphiphiles show peculiar concentration dependence: at low concentrations, they exist as monomers, but on increasing surfactant concentration, the monomers aggregate into a variety of thermodynamically stable structures known as micelles (direct or reverse, spherical, or nonspherical), microtubules, vesicles (e.g., liposomes), and other bilayered structures (Chauhan & Pathania, 2018; Pathania & Chauhan, 2020a). Surfactant micellization can be influenced by temperature, pH, or the addition of various organic/inorganic solutes which can bring alterations in surfactant–surfactant and surfactant–solvent interactions in solution.…”

Section: Introductionmentioning

confidence: 99%

Insight of molecular interactions between short‐chain tetraalkylammonium bromides and cetyltrimethylammonium bromide: A spectroscopic and thermodynamic approach

Chauhan

Negi

2023

J Surfact & Detergents

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The influence of tetraalkylammonium salts, viz., tetraethylammonium, tetrapropylammonium, and tetrabutylammonium bromides (0.005, 0.010, 0.015 mol kg−1) on the micellar behavior of aqueous solutions of the cationic surfactant cetyltrimethylammonium bromide (CTAB, 0.2–2 mmol kg−1) over the 298.15–313.15 K temperature range has been studied by conductometric method. From conductivity versus surfactant concentration plots, the critical micelle concentration (CMC) of CTAB has been determined, which shows that the tetraalkylammonium bromides promote the formation of CTAB aggregates. Further, from the temperature dependence of CMC values, the degree of ionization, the counterion binding constant along with some thermodynamic parameters of micellization, such as standard free energy change (), standard enthalpy change (), standard entropy change () have been calculated. From the values of , and , it has been concluded that our ternary system is both enthalpy as well as entropy controlled. Similar CMC values were obtained from UV–Visible spectrometry measurements, using pyrene as a probe at ambient temperature. Also 1H‐NMR and FTIR methods give a greater understanding of the molecular scale interactions between the tetraalkylammonium bromides and the cationic surfactant.

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“…Therefore, there is great signicance of the micelle aggregate of amphiphile to dissolve the water-insoluble medicines to reduce toxicity, and increase bio-availability. 11 Due to the large surface area, surfactant micelle can be added toward chemical reactions to increase the rate of reaction rate termed as catalyst. 12,13 The micelle structure is concerned with the bio-membrane arrangement.…”

Section: Introductionmentioning

confidence: 99%

A recent overview of surfactant–drug interactions and their importance

Pokhrel

Sah

Gautam³

et al. 2023

RSC Adv.

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Aggregation and interactional behavior of cationic surfactants in the presence of cephalosporin drug: A thermo-acoustic and spectroscopic approach

Cited by 18 publications

References 58 publications

Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study

Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study

Insight of molecular interactions between short‐chain tetraalkylammonium bromides and cetyltrimethylammonium bromide: A spectroscopic and thermodynamic approach

A recent overview of surfactant–drug interactions and their importance

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