A recent overview of surfactant–drug interactions and their importance

Pokhrel, Dilli Ram; Sah, Manish Kumar; Gautam, Bibaran; Basak, Hriday Kumar; Bhattarai, Ajaya; Chatterjee, Abhik

doi:10.1039/d3ra02883f

Cited by 31 publications

(6 citation statements)

References 110 publications

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“…Furthermore, it has been reported that surfactants usually increase the solubility of insoluble drugs in organic solvents or in water. − Increased solubility, on the one hand, raises the degree of subcooling required for nucleus precipitation during microdroplet quenching and cooling, leading to finer crystals or even amorphous forms. On the other hand, it reduces the supersaturation degree of the microcrystal suspension, decreasing the driving force for the growth of fine particles.…”

Section: Resultsmentioning

confidence: 99%

A Scalable Freeze-Dissolving Approach to Prepare Ultrafine Crystals for Inhalation: Mechanism and Validation

Guo,

Cao,

Zhang

et al. 2024

Crystal Growth & Design

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Inhaled drug delivery has garnered increasing attention due to its inherent advantages including rapid onset of action, targeted delivery, high bioavailability, and reduced side effects, which holds promise for the treatment of localized lung diseases and systemic diseases. The currently dominant technologies for the preparation of inhalants are air flow pulverization, media milling, and spray drying, which encounter challenges such as inaccurate particle size control, inefficiency, instability, and difficulties in scaling up. The present study proposes a freezedissolving technique (FDT) for the preparation of inhalable microcrystals, comprising two essential steps: rapid freezing of microdroplets into iced pellets within seconds and subsequent dissolution of a solvent in the iced pellets to release the microcrystals in a suspension. By employing the FDT technique, griseofulvin, a representative inhalant, was successfully engineered into a bipyramidal morphology with a targeted particle size (<5 μm), minimal agglomeration (<3%), and an aspect ratio below 2, in which the solvent and stabilizer systems played pivotal roles in facilitating or impeding nucleation and crystal growth processes. To verify the universality of the FDT, six other typical inhalant preparation processes were successfully developed based on the FDT with a controllable crystal size between 1 and 10 μm. Furthermore, three out of the aforementioned seven model substances were randomly selected, and their preparation was scaled up by a factor of 100, yielding consistent results with those obtained at a smaller test scale. This study outlines the freeze-dissolving mechanism in ultrafine crystal formation and demonstrates that the FDT is a robust and scalable approach for the production of inhalants.

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Section: Resultsmentioning

confidence: 99%

A Scalable Freeze-Dissolving Approach to Prepare Ultrafine Crystals for Inhalation: Mechanism and Validation

Guo,

Cao,

Zhang

et al. 2024

Crystal Growth & Design

View full text Add to dashboard Cite

show abstract

“…Numerous amphiphilic compounds have been extensively used in a variety of industries, including farming, food engineering, oil industry, environmental and biological areas, pharmaceutical technology, textiles, and metallurgy. [1][2][3][4][5][6][7][8][9][10] These molecules are composed of two parts: (i) a hydrophobic component that prefers oil to water and (ii) a hydrophilic component that prefers water to oil. Above their CMC, these amphiphilic compounds in an aqueous environment can form a molecular self-assembly, which is referred to as a micelle.…”

Section: Introductionmentioning

confidence: 99%

Study on the association and phase separation behavior of surfactants and promethazine hydrochloride: impact of ammonium electrolytes

Shah,

Islam,

Albaqami

et al. 2024

RSC Adv.

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“…Additionally, antibiotics can disrupt the balance of microorganisms in aquatic environments, influencing the overall health of these ecosystems. , It is thus important to monitor and find possible ways to isolate these drugs from water sources using secondary techniques such as foam fractionation . Numerous works have been performed on removing or minimizing the antibiotic concentrations in water with the help of various techniques such as adsorption, , advanced oxidation processes, , membrane filtration, , biological treatment methods, , and using various surfactants. − …”

Section: Introductionmentioning

confidence: 99%

Ciprofloxacin and Azithromycin Antibiotics Interactions with Bilayer Ionic Surfactants: A Molecular Dynamics Study

Acharya,

Carpenter,

Madakyaru

et al. 2024

ACS Omega

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The introduction of pharmaceuticals into aquatic ecosystems can lead to the generation of antibiotic-resistant bacteria. This paper employed molecular dynamics simulations to examine the interactions between cationic/ anionic surfactants and two antibiotics or drugs, namely, ciprofloxacin and azithromycin. The analysis focused on many factors to elucidate the mechanism by which the surfactant bilayer molecular structure affects the selected antibiotics. These factors include the tilt angle, rotational angle of the surfactants, electrostatic potential, and charge density along the bilayers. Our molecular-level investigation of the adsorption mechanisms of hydrophobic (azithromycin) and hydrophilic (ciprofloxacin) drugs on the cationic/anionic surfactant bilayer offers a crucial understanding for comprehending the optimal selection of surfactants for effectively separating antibiotics.

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A recent overview of surfactant–drug interactions and their importance

Abstract: Interactions between surfactants and drugs.

Cited by 31 publications

References 110 publications

A Scalable Freeze-Dissolving Approach to Prepare Ultrafine Crystals for Inhalation: Mechanism and Validation

A Scalable Freeze-Dissolving Approach to Prepare Ultrafine Crystals for Inhalation: Mechanism and Validation

Study on the association and phase separation behavior of surfactants and promethazine hydrochloride: impact of ammonium electrolytes

Ciprofloxacin and Azithromycin Antibiotics Interactions with Bilayer Ionic Surfactants: A Molecular Dynamics Study

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