Agglutination of bacteria using polyvalent nanoparticles of aggregation-induced emissive thiophthalonitrile dyes

Schmidt, Bettina; Sankaran, Shrikrishnan; Stegemann, Linda; Strassert, Cristian A.; Jonkheijm, Pascal; Voskuhl, Jens

doi:10.1039/c6tb01210h

Cited by 33 publications

(28 citation statements)

References 21 publications

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“…c) Structures of particle constructed from glycosylated thio‐phthalonitriles and representation of the aggregation between lectins/bacteria and the assembled particle. Reproduced with permission . Copyright 2016, The Royal Society of Chemistry.…”

Section: Carbohydrate‐conjugated Nanomaterialsmentioning

confidence: 99%

“…This system effectively targeted MDA‐MB‐231 cells overexpressing the mannose receptor (MR) for theranostics (Figure 17b). Mannosylated amphiphilic thio‐phthalonitriles were self‐assembled into AIE (aggregation‐induced emission)‐based particles in water, to interact with Con A (concanavalin A, mannose‐selective) and with the E. coli strain ORN178 over ORN208 based on selective bacterial aggregation, enabling their fluorescence detection (Figure 17c).…”

Section: Carbohydrate‐conjugated Nanomaterialsmentioning

confidence: 99%

“…CuAAC (copper‐catalyzed azide–alkyne cycloaddition) was one of the most commonly used strategy shown in this review, due its high chemical yield, wide substrate scope, and mild reaction conditions . Researchers have also extensively exploited the high affinity of sulfur functional groups for Au .…”

Section: Brief Overview Of the Bio‐conjugation Chemistry And Strategimentioning

confidence: 99%

“…Reproduced with permission. [178] Copyright 2016, The Royal Society of Chemistry. d) Structure of P3HT and two glycosylated probes before the self-assembly with PSMA to form a complex FACILITATING cell entry and cell death, and fluorescence imaging in two cells with receptors of galactose and mannose, respectively, as well as in control HeLa cells.…”

Section: Particular Materialsmentioning

confidence: 99%

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Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Kwon

Yan

et al. 2020

Adv Funct Materials

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Human beings are “machines” that use endogenously produced biomolecules as “components” in signaling and for the maintenance of the body. These biomolecules consist of proteins, nucleic acids, and carbohydrates, which can either be extracted from biological substrates or synthesized by chemical/biochemical methods. These biomolecules have the ability to recognize/interact with other biomolecules that are overexpressed in disease cells. For targeted theranostics, strategies to chemically incorporate these natural biomolecules with advanced materials to treat human diseases by imaging‐guided drug delivery or photodynamic/photothermal therapy are proposed, with improved biocompatibility. Herein, recent research on construction of quantum dots, nanoparticles, and 2D material platforms decorated with antibodies, peptides, nucleic acid aptamers, carbohydrates, and folic acid for targeted diagnosis and treatment are summarized and discussed. In addition, the various strategies required to construct effective functional materials for targeted cancer therapy are highlighted. The hope is that this review can inspire and guide those that are interested in the field of biomedicine to rationally design and develop new target‐based theranostic materials.

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Section: Carbohydrate‐conjugated Nanomaterialsmentioning

confidence: 99%

Section: Carbohydrate‐conjugated Nanomaterialsmentioning

confidence: 99%

Section: Brief Overview Of the Bio‐conjugation Chemistry And Strategimentioning

confidence: 99%

Section: Particular Materialsmentioning

confidence: 99%

See 2 more Smart Citations

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Kwon

Yan

et al. 2020

Adv Funct Materials

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“…Furthermore, it was found that a simple tuning of emission wavelength can be obtained by variations of the substitution pattern as well as the introduction of different functional groups. Besides that, the self‐assembly of these compounds into micelles and rods as well as the application in molecular recognition of biomolecules was intensively investigated. Here we describe the synthesis of alkylated AIE emitters, including a detailed investigation of the photophysical properties in different solvents, the aggregation behavior as well as a detailed structure‐property relationship discussion based on X‐ray diffraction analysis data.…”

Section: Introductionmentioning

confidence: 99%

Alkylated Aromatic Thioethers with Aggregation‐Induced Emission Properties—Assembly and Photophysics

Riebe

Saccone

Stelzer

et al. 2018

Chemistry An Asian Journal

Self Cite

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In this contribution, we present the synthesis and self‐assembly of alkylated thioethers with interesting photophysical properties. To this end, the emission, absorption and excitation spectra in organic solvents and as aggregates in water were measured as well as the corresponding photoluminescence quantum yields and lifetimes. The aggregates in aqueous media were visualized and measured using transmission electron microscopy. Besides that, crystal structures of selected compounds allowed a detailed discussion of the structure–property relationship. Furthermore, the mesomorphic behavior was investigated using polarized optical microscopy (POM) as well as differential scanning calorimetry (DSC).

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Glycosylated MoS₂ Sheets for Capturing and Deactivating E. coli Bacteria: Combined Effects of Multivalent Binding and Sheet Size

Bhatia

Fan

et al. 2022

Adv Materials Inter

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human lifespan. Antibiotic resistance occurs naturally, however, the misuse of antibiotics has now accelerated this process and presented it as a major threat to global heath, food security, and drinking water safety. [2] Hence, novel alternative antimicrobials are urgently needed to address this increasing concern.With the rapid development of nanotechnology, novel nanomaterials developed by researchers offer various anti-infective strategies to combat bacterial infections, such as targeted antibiotic therapy, photothermal therapy (PTT), and photodynamic therapy (PDT). [5,6] Especially, 2D materials, such as graphene, black phosphorus, MXenes, and transitional metal dichalcogenides (TMDs) are currently being explored extensively in biomedicine, since they have ultrathin structures, high specific surface areas, and unique physicochemical characteristics, which are suitable for fabricating multivalent interaction. [7] MoS 2 in particular shows high photothermal conversion efficiency, low toxicity, and excellent biodegradability. [8] These advantages make it superior to other 2D materials and endow it with great potential to be a photo thermal transduction agent in PTT. [7,[9][10][11] Previous studies have shown that the physicochemical properties of nanomaterials, such as lateral dimension, morphology, surface charge, and functionalities, are crucial to their biological behaviors. [12][13][14] For example, Zhang et al. reported that larger and thicker black phosphorous has the higher cellular cytotoxicity, whereas smaller one only shows moderate toxicity. [15] Yang et al. and Chen et al. separately reported that the particulate size and surface chemistry of graphene oxide (GO) is critical to its biological behaviors, especially in vivo. [16,17] However, up to now, the published works on MoS 2 for antibacterial applications mainly pursue the enhanced microcidal activities of MoS 2 hybrid composites. [18][19][20][21] Few reports have investigated MoS 2 as a multivalent binding platform against bacteria, and the effects of MoS 2 's lateral size on antibacterial activities remain to be studied.Multivalent interactions on the cell surface are essential to cell signaling, recognition cascades, and viral and bacterial infection processes. [22,23] For example, E. coli bacteria have rodlike FimH, which can bind multivalently to mannosylated glycoproteins and facilitate the adhesion of E. coli to host cells. [24,25] Though multivalent inhibitors do not show strong bactericidal activity, large multivalent bacteria binders significantly Molybdenum disulfide (MoS 2 ) holds great promise for antibacterial applications owing to its strong photothermal performance and biocompatibility. Most of its antibacterial explorations have sought enhanced antibacterial potency through designing new hybrid inorganic materials, the relationship between its physiochemical properties and antibacterial activities has yet to be explored. This work is the first to investigate the combination effects of different sized and functionalized MoS 2 shee...

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Agglutination of bacteria using polyvalent nanoparticles of aggregation-induced emissive thiophthalonitrile dyes

Cited by 33 publications

References 21 publications

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Alkylated Aromatic Thioethers with Aggregation‐Induced Emission Properties—Assembly and Photophysics

Glycosylated MoS₂ Sheets for Capturing and Deactivating E. coli Bacteria: Combined Effects of Multivalent Binding and Sheet Size

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Agglutination of bacteria using polyvalent nanoparticles of aggregation-induced emissive thiophthalonitrile dyes

Cited by 33 publications

References 21 publications

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Alkylated Aromatic Thioethers with Aggregation‐Induced Emission Properties—Assembly and Photophysics

Glycosylated MoS2 Sheets for Capturing and Deactivating E. coli Bacteria: Combined Effects of Multivalent Binding and Sheet Size

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Product

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Glycosylated MoS₂ Sheets for Capturing and Deactivating E. coli Bacteria: Combined Effects of Multivalent Binding and Sheet Size