Age structure and dynamics of the morbidity rate of respiratory and autonomous nervous system diseases in children living in conditions of the aerogenous impact of chemical factors of technogenic origin (cohort study)

Abstract

There was executed a 6-years cohort study of 65 children divided into an observation group comprising of 45 cases residing in the conditions of atmosphere air contaminated by a complex of chemical substances of technogenic origin (suspended solids, phenol, formaldehyde), and a comparative group (20 children) from the area with beneficiary sanitary-hygienic conditions. In conditions of the impact of these chemical substances in children reaching of the age of 7-10 years the prevalence of allergic rhinitis and vegetative disorders was established to increase by 1.2-1.9 times, and the risk of getting sick with bronchial asthma is growing by more than twice; by 11-14 years the risk of spreading of allergic rhinitis is additionally growing by 1.4 times against the background of the decreasing in the probability of forming of chronic lympho-proliferative processes of nasopharynx and secondary immunodeficiency. The frequency of the development of vegetative dysfunctions increases twice over the 6 years period in children residing in conditions of persistent aerogenous combined impact of suspended solids, phenol and formaldehyde.

Markers showing allergic reactions in children caused by aerogenic exposure to manganese and nickel compounds

“…Being predominantly haptens, inhaled chemicals with sensitizing properties oxidize due to metabolism and combine with proteins thus creating specific complex antigens; these antigens induce releasing local inflammation mediators and histamine liberation [16]. Initially negative environmental factors act as triggers or primers that stimulate pathogenic processes in critical organs and systems together with destabilization in adaptation processes and damage done to resistance mechanisms [17][18][19][20].…”

Assessing risks of respiratory organs diseases and co-morbid pathology in children caused by ambient air contamination with technogenic chemicals (co-hort study)

“…According to numerous research works, an adverse ecological situation causes risks of health disorders among children, first of all, in the respiratory organs [4][5][6][7][11][12][13][14][15][16]. Incidence with respiratory pathologies tends to be 2.0-4.6 times higher in industrial cities; it is especially true for allergic diseases and secondary immune failures with their prevalence being by 1.5 times higher than in the country on average [4,6,7,[14][15][16][17]. Diseases of the respiratory organs are known to be mostly recurrent under exposure to adverse technogenic chemical factors and they are often combined with various syndromes and diseases [13][14][15][16].…”

“…Incidence with respiratory pathologies tends to be 2.0-4.6 times higher in industrial cities; it is especially true for allergic diseases and secondary immune failures with their prevalence being by 1.5 times higher than in the country on average [4,6,7,[14][15][16][17]. Diseases of the respiratory organs are known to be mostly recurrent under exposure to adverse technogenic chemical factors and they are often combined with various syndromes and diseases [13][14][15][16]. When a concomitant pathology occurs, it makes drastic changes in a clinical picture of the main pathologic process and determines nature and gravity of possible complications; all the above mentioned makes it difficult to diagnose and treat a disease and deteriorates a patient's life quality [4,[16][17][18].…”

Assessing risks of respiratory organs diseases and co-morbid pathology in children caused by ambient air contamination with technogenic chemicals (co-hort study)

“…Согласно многочисленным исследованиям, неблагоприятная экологическая обстановка формирует риск развития нарушений состояния здоровья детского населения, в первую очередь со стороны органов дыхания [4][5][6][7][11][12][13][14][15][16]. На территориях промышленных городов отмечается более высокий уровень заболеваемости респираторной патологией (до 2,0-4,6 раза), особенно аллергической природы, вторичных иммунодефицитных состояний (до 1,5 раза) [4,6,7,[14][15][16][17]. Известно, что в условиях негативного воздействия техногенных химических факторов болезни органов дыхания имеют рецидивирующее течение и зачастую сочетаются с несколькими синдромами и заболеваниями [13][14][15][16].…”

“…На территориях промышленных городов отмечается более высокий уровень заболеваемости респираторной патологией (до 2,0-4,6 раза), особенно аллергической природы, вторичных иммунодефицитных состояний (до 1,5 раза) [4,6,7,[14][15][16][17]. Известно, что в условиях негативного воздействия техногенных химических факторов болезни органов дыхания имеют рецидивирующее течение и зачастую сочетаются с несколькими синдромами и заболеваниями [13][14][15][16]. Наличие сопутствующей патологии значительно изменяет клиническую картину основного патологического процесса, определяет развитие характера и тяжести осложнений, что весьма затрудняет лечебно-диагностический процесс и ухудшает качество жизни больного [4,[16][17][18].…”