Age-related structural changes in the myenteric nervous plexus ganglion along the anterior wall of the proximal human duodenum: A morphometric analysis

Mandic, Predrag; Leštarević, Snežana; Filipović, Tatjana; Djukic-Macut, Natasa; Saranovic, Milena

doi:10.2298/vsp1302177m

Cited by 7 publications

(4 citation statements)

References 10 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No gender-specific differences were observed. Similar to this observation, in human duodenum/jejunum samples from older individuals (65-84 years, n = 10), ganglion structures were often found with no nerve cell bodies due to loss of neurons, but the surface area of the ganglion structures of the MP per se did not decrease [22,23].…”

Section: Morphological Changes Of the Aging Enssupporting

confidence: 73%

“…Many studies suggest that aging results in a loss of myenteric neuronal density [19,22,23,26,[29][30][31]34,41,46,47,51,54] and number [29,32,46,52] (see Table 1). For example, Mandic et al showed a decrease in the number of myenteric neurons per cm 2 by 25.93% in the aged group (65-84 years) compared to the youngest group (20-44 years) and by 23.32% in relation to the middle-aged group (45-64 years) [22].…”

Section: Aging Ens Leads To Age-related Gi Innervation Changesmentioning

confidence: 99%

See 1 more Smart Citation

The Aging Enteric Nervous System

Nguyen

Baumann

Tüscher

et al. 2023

IJMS

View full text Add to dashboard Cite

The gut and the brain communicate via the nervous system, hormones, microbiota-mediated substances, and the immune system. These intricate interactions have led to the term “gut-brain axis”. Unlike the brain—which is somewhat protected—the gut is exposed to a variety of factors throughout life and, consequently, might be either more vulnerable or better adapted to respond to these challenges. Alterations in gut function are common in the elder population and associated with many human pathologies, including neurodegenerative diseases. Different studies suggest that changes in the nervous system of the gut, the enteric nervous system (ENS), during aging may result in gastrointestinal dysfunction and initiate human pathologies of the brain via its interconnection with the gut. This review aims at summarizing the contribution of normal cellular aging to the age-associated physiological changes of the ENS. Morphological alterations and degeneration of the aging ENS are observed in different animal models and humans, albeit with considerable variability. The aging phenotypes and pathophysiological mechanisms of the aging ENS have highlighted the involvement of enteric neurons in age-related diseases of the central nervous system such as Alzheimer’s or Parkinson’s disease. To further elucidate such mechanisms, the ENS constitutes a promising source of material for diagnosis and therapeutic predictions, as it is more accessible than the brain.

show abstract

Section: Morphological Changes Of the Aging Enssupporting

confidence: 73%

Section: Aging Ens Leads To Age-related Gi Innervation Changesmentioning

confidence: 99%

The Aging Enteric Nervous System

Nguyen

Baumann

Tüscher

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…In our study, in serosa number of enteric ganglia was decreased in early weeks, increased in midweeks and decreased in late weeks, in between the muscle layers they were increased in early and midweeks and decreased in late weeks whereas in submucosa (p = 0.01) they were decreased in early weeks and increased in mid and late weeks. Our study showed that there is fluctuation in the number of enteric ganglia as the gestational age progresses but age-related studies described that there are empty ganglia with less number of neurons 17 , 18 and studies in gastrointestinal diseases described that there is decrease in the number of ganglia. 19 …”

Section: Discussionmentioning

confidence: 46%

Histomorphology of enteric neurons and enteric ganglia in different layers of human fetal colon

Bhattarai

Poudel

Ghosh

et al. 2022

Journal of Taibah University Medical Sciences

View full text Add to dashboard Cite

“…102 Within human small intestine, no agedependent changes were found in surface area of enteric ganglia within the duodenum, but the number of neurons was smaller (~16%) within the elderly (65-84 years; n = 30 donors but distribution among different age groups not stated). 116 By contrast, an increased number of NOS-expressing myenteric neurons were reported in terminal ileum of the elderly (78-86 years; n = 8 vs. n = 7 younger adults; all with cancer of ascending colon 117 ).…”

Section: Myenteric Plexusmentioning

confidence: 94%

The human colon: Evidence for degenerative changes during aging and the physiological consequences

Baidoo,

Sanger

2024

Neurogastroenterology Motil

View full text Add to dashboard Cite

BackgroundThe incidence of constipation increases among the elderly (>65 years), while abdominal pain decreases. Causes include changes in lifestyle (e.g., diet and reduced exercise), disease and medications affecting gastrointestinal functions. Degenerative changes may also occur within the colo‐rectum. However, most evidence is from rodents, animals with relatively high rates of metabolism and accelerated aging, with considerable variation in time course. In humans, cellular and non‐cellular changes in the aging intestine are poorly investigated.PurposeTo examine all available studies which reported the effects of aging on cellular and tissue functions of human isolated colon, noting the region studied, sex and age of tissue donors and study size. The focus on human colon reflects the ability to access full‐thickness tissue over a wide age range, compared with other gastrointestinal regions. Details are important because of natural human variability.We found age‐related changes within the muscle, in the enteric and nociceptor innervation, and in the submucosa. Some involve all regions of colon, but the ascending colon appears more vulnerable. Changes can be cell‐ and sublayer‐dependent. Mechanisms are unclear but may include development of “senescent‐like” and associated inflammaging, perhaps associated with increased mucosal permeability to harmful luminal contents.In summary, reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes within the colon wall may have little impact on symptoms and colonic functions, because of high “functional reserve,” but are likely to facilitate the development of constipation during age‐related challenges (e.g., lifestyle, disease, and medications), now operating against a reduced functional reserve.

show abstract

Age-related structural changes in the myenteric nervous plexus ganglion along the anterior wall of the proximal human duodenum: A morphometric analysis

Cited by 7 publications

References 10 publications

The Aging Enteric Nervous System

The Aging Enteric Nervous System

Histomorphology of enteric neurons and enteric ganglia in different layers of human fetal colon

The human colon: Evidence for degenerative changes during aging and the physiological consequences

Contact Info

Product

Resources

About