Background: Variations in origin, course, branching pattern, termination and connections of the musculocutaneous nerve in the arm are not as uncommon as was once thought. Variational study of nerve in Nepalese is very less and can be of surigical-clinical importance. This opinion led us to performing this study. Objectives: The aim of this study was to a study in Nepalese which could be important for clinical investigation and the surgical treatment of peripheral nerve injury. Materials and methods: This study was carried out in Manipal College of medical sciences (MCOMS). Dissection of formalised 16 cadavers (n=32 upper limbs) were carried out using normal dissection kit with the help of standard dissection manual in two and half years. Results: The study revealed the variation in course, branching pattern and termination of musculocutaneous nerve in 6.25% of cases unilaterally on the right side. No statistically significant differences by gender and side were observed. Conclusion: This present study provides the evidence of variation of musculocutaneous nerve in Nepalese. The knowledge of the anatomical variations of the peripheral nerve system can help explain an incomprehensible clinical sign. Key words: Musculocutaneous nerve; Median nerve; Brachial plexus; Peripheral nerve repair. DOI: 10.3126/kumj.v7i4.2763 Kathmandu University Medical Journal (2009) Vol.7, No.4 Issue 28, 408-410
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<p>Enteric neurons and ganglia are derived from vagal and sacral neural crest cells, which undergo migration from the neural tube to the gut wall. In the gut wall, they first undergo rostrocaudal migration followed by migration from the superficial to deep layers. After migration, they proliferate and differentiate into the enteric plexus. Expression of the Rearranged During Transfection (<italic>RET</italic>) gene and its protein RET plays a crucial role in the formation of enteric neurons. This review describes the molecular mechanism by which the <italic>RET</italic> gene and the RET protein influence the development of enteric neurons. Vagal neural crest cells give rise to enteric neurons and glia of the foregut and midgut while sacral neural crest cells give rise to neurons of the hindgut. Interaction of RET protein with its ligands (glial cell derived neurotrophic factor (GDNF), neurturin (NRTN), and artemin (ARTN)) and its co-receptors (GDNF receptor alpha proteins (GFRα1-4)) activates the Phosphoinositide-3-kinase-protein kinase B (PI3K-PKB/AKT), RAS mitogen-activated protein kinase (RAS/MAPK) and phospholipase Cγ (PLCγ) signaling pathways, which control the survival, migration, proliferation, differentiation, and maturation of the vagal and sacral neural crest cells into enteric neurons. Abnormalities of the <italic>RET</italic> gene result in Hirschsprung's disease.</p>
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