Age-related changes of standardized uptake values in the blood pool and liver: a decade-long retrospective study of the outcomes of 2,526 subjects

Cao, Yuan; Zhou, Ke; Diao, Wei; Long, Xipeng; Tian, Fei; Su, Minggang; Jia, Zhiyun

doi:10.21037/qims-20-35

Cited by 17 publications

(16 citation statements)

References 36 publications

(53 reference statements)

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“…Since aged livers are associated with less blood perfusion and decreased hepatocyte number, one would expect aged livers have less fluorine-18-FDG uptake. However, it has been well documented that aging is associated with an increase of both liver maximum standard uptake value (SUVmax) and liver mean standard uptake value (SUVmean) on FDG positron emission tomography (PET) imaging (11,(70)(71)(72). Cao et al (72) studied a total of 2,526 subjects underwent FDG PET/CT examinations, and reported that liver SUVmax and SUVmean rise rapidly until the age of 20 and then show a slow upward trend without reaching a plateau (Figure 8).…”

Section: Increase Of Liver Fluorodeoxyglucose (Fdg) Uptake With Agingmentioning

confidence: 99%

“…However, it has been well documented that aging is associated with an increase of both liver maximum standard uptake value (SUVmax) and liver mean standard uptake value (SUVmean) on FDG positron emission tomography (PET) imaging (11,(70)(71)(72). Cao et al (72) studied a total of 2,526 subjects underwent FDG PET/CT examinations, and reported that liver SUVmax and SUVmean rise rapidly until the age of 20 and then show a slow upward trend without reaching a plateau (Figure 8). Meier et al (11) noted that, the metabolic activity of the liver increases significantly with age in adults, and the overall metabolic volumetric product, a measure that takes into account an organ's volume and metabolism by multiplying the hepatic volume by the hepatic mean SUV, trend slightly upward with age.…”

Section: Increase Of Liver Fluorodeoxyglucose (Fdg) Uptake With Agingmentioning

confidence: 99%

“…The causes for this significant increase in liver metabolism in aging liver have not been fully elucidated (72). It may reflect cumulative inflammatory changes secondary to increasing duration of exposure to processing of toxins by liver (71).…”

Section: Increase Of Liver Fluorodeoxyglucose (Fdg) Uptake With Agingmentioning

confidence: 99%

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Gender-specific liver aging and magnetic resonance imaging

Wáng¹

2021

Quant Imaging Med Surg

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The number of imaging studies performed on elderly individuals will increase in the next several decades. It is important to understand normal age-related changes in the structural and functional imaging appearance of the liver. Healthy aging of organs is a well-studied topic and covered in many imaging literatures. Aging of some organs such as brain, spine, hip/knee joints etc. can be well noted on imaging (1-3). For example, intervertebral disc nucleus pulposus appears high signal in young subjects, while typically appear grey/low signal in older subjects. A grey/low signal disc nucleus pulposus would suggest degeneration if seen among young subjects, but considered part of normal aging in elderly subjects (3). Quantitative T2 and T1rho relaxation times of the disc nucleus pulposus show apparent reduction with healthy aging (4). However, the aging of liver has got less attention among radiology

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Section: Increase Of Liver Fluorodeoxyglucose (Fdg) Uptake With Agingmentioning

confidence: 99%

Section: Increase Of Liver Fluorodeoxyglucose (Fdg) Uptake With Agingmentioning

confidence: 99%

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Gender-specific liver aging and magnetic resonance imaging

Wáng¹

2021

Quant Imaging Med Surg

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“…The effect of hypothyroidism on referential background metabolic activity on 18 F-FDG PET/CT blood pool and the liver is often used as references for accurate treatment response interpretation (1)(2)(3). However, variations in biological factors such as blood glucose level and incubation time (time from FDG injection to PET/ CT scan) can affect the 18 F-FDG uptake in these regions (4)(5)(6)(7). This can be problematic when a metabolic response is defined, especially for quantitative evaluation, based on the PET Response Criteria in Solid Tumors (PERCIST).…”

Section: Original Articlementioning

confidence: 99%

The effect of hypothyroidism on referential background metabolic activity on 18F-FDG PET/CT

Yang¹,

Qing²,

Cai³

et al. 2021

Quant Imaging Med Surg

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Background: Background uptake activity is used as a reference to assess treatment response by positron emission tomography-computed tomography (PET/CT) with 2-deoxy-2- [F-18]fluoro-D-glucose ( 18 F-FDG).Prior studies have reported decreased liver and increased muscle 18 F-FDG uptake in patients with hyperthyroidism. We hypothesized that hyperthyroidism and hypothyroidism might have inverse effects on 18 F-FDG uptake on PET/CT. Methods: We recruited 36 patients with hypothyroidism and 36 age and gender-matched euthyroid participants. We recorded patient factors and background mean standardized uptake values normalized by lean body mass from the aortic blood pool, liver, and muscle. We compared the patient factors and background standardized uptake values normalized by lean body mass between hypothyroidism patients and the controls. We performed a multivariate analysis to determine the best predictors of the 3 different background standardized uptake values normalized by lean body mass. Results: Patients with hypothyroidism had higher liver standardized uptake values normalized by lean body mass (1.77±0.33 vs. 1.58±0.26, P=0.009) and aortic blood-pool standardized uptake values normalized by lean body mass (1.21±0.22 vs. 1.11±0.20, P=0.040) than the controls. In contrast, the muscle standardized uptake value normalized by lean body mass (0.50±0.09 vs. 0.54±0.09, P=0.044) of the patients with hypothyroidism was lower than that of the controls. The serum level of thyroid-stimulating hormone was an independent predictor of liver standardized uptake values normalized by lean body mass (β=0.356, P<0.001) and bloodpool standardized uptake values normalized by lean body mass (β=0.288, P=0.001). The serum level of free triiodothyronine was an independent predictor of muscle standardized uptake values normalized by lean body mass (β=0.310, P=0.002).Conclusions: PET/CT scans showed that hypothyroidism patients had increased liver and blood-pool 18 F-FDG uptake and decreased skeletal muscle 18 F-FDG uptake compared with euthyroid individuals. These alterations should be noted when a metabolic response to cancer treatment on PET/CT is determined.

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“…The Deauville classification of FDG PET response, first published in 2009, is 5-point PET scoring system based on maximum standardized uptake volume (SUVmax) relative to reference tissues (mediastinal blood pool and liver), that predict the response of lymphomas to treatment ( Table 3 ) [ 4 , 49 ]. Although there is some evidence of age-related changes in metabolic activity in background tissues [ 50 ], metabolic activity in the liver and mediastinal blood pool are regarded as being relatively stable from one imaging session to the next. This system was further refined based on the outcome of an international workshop in Menton, FR in 2014 to include a wider range of lymphomas, to apply the scoring system to end-of-treatment FDG PET-CT (ePET) as well as interim PET-CT (iPET), and to introduce the concept of ΔSUVmax from baseline to iPET [ 51 ].…”

Section: Hematologic Malignanciesmentioning

confidence: 99%

PET-CT in Clinical Adult Oncology: I. Hematologic Malignancies

Salem

Shah

Covington

et al. 2022

Cancers

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PET-CT is an advanced imaging modality with many oncologic applications, including staging, assessment of response to therapy, restaging and evaluation of suspected recurrence. The goal of this 6-part series of review articles is to provide practical information to providers and imaging professionals regarding the best use of PET-CT for the more common adult malignancies. In the first article of this series, hematologic malignancies are addressed. The classification of these malignancies will be outlined, with the disclaimer that the classification of lymphomas is constantly evolving. Critical applications, potential pitfalls, and nuances of PET-CT imaging in hematologic malignancies and imaging features of the major categories of these tumors are addressed. Issues of clinical importance that must be reported by the imaging professionals are outlined. The focus of this article is on [18F] fluorodeoxyglucose (FDG), rather that research tracers or those requiring a local cyclotron. This information will serve as a resource for the appropriate role and limitations of PET-CT in the clinical management of patients with hematological malignancy for health care professionals caring for adult patients with hematologic malignancies. It also serves as a practical guide for imaging providers, including radiologists, nuclear medicine physicians and their trainees.

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Age-related changes of standardized uptake values in the blood pool and liver: a decade-long retrospective study of the outcomes of 2,526 subjects

Cited by 17 publications

References 36 publications

Gender-specific liver aging and magnetic resonance imaging

Gender-specific liver aging and magnetic resonance imaging

The effect of hypothyroidism on referential background metabolic activity on 18F-FDG PET/CT

PET-CT in Clinical Adult Oncology: I. Hematologic Malignancies

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