Age-related changes in serological susceptibility patterns to measles

Xiong, Yuyan; Wang, Dong; Lin, Weiyan; Tang, Hao; Chen, Shaoli; Ni, Jiajia

doi:10.4161/hv.27734

Cited by 21 publications

(7 citation statements)

References 15 publications

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“…This age range spans several decades, including people who were very likely infected during childhood. Similar trends have been reported in other studies 22,23 .…”

Section: Discussionsupporting

confidence: 92%

Seroprevalence of measles antibodies and factors associated with susceptibility: a national survey in Mexico using a plaque reduction neutralization test

Díaz-Ortega

Ferreira-Guerrero

Cruz-Hervert

et al. 2020

Sci Rep

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Measles continues to be one of the leading causes of child mortality worldwide, even though a highly effective vaccine has existed for more than 40 years. We aimed to describe the seroprevalence of measles antibodies in Mexico in 2012 and the risk factors associated with susceptibility. A total of 7,785 serum samples were analyzed from the National Health and Nutrition Survey in Mexico. This national survey is representative of the general population, including noninstitutionalized adult, adolescent, and child populations. Antibody titers were classified into protective (> 120 mIU/mL) or susceptible (≤ 120 mIU/mL) levels. The weighted seroprevalence and susceptibility of the overall population were 99.37% (95% CI 99.07–99.58) and 0.63% (95% CI 0.42–0.93), respectively. Among 1-to-4-year-old children, 2.18% (95% CI 1.36–3.48) were susceptible to measles. Among adolescents and young adults, the prevalence of susceptibility was as follows: those 15–19 years of age had a prevalence of 0.22% (95% CI 0.09–0.57), and those 30–39 years of age had a prevalence of 1.17% (95% CI 0.47–2.85). Susceptibility was associated with young age, living in Mexico City, living in crowded households and unknown or nonvaccinated status among 1- to 5-year-old children. Although the overall sample population seroprevalence for measles is above 95%, increased susceptibility among younger children signals the importance of the timely administration of the first vaccine dose at 12 months of age. Furthermore, increased susceptibility among specific subgroups indicates the need to reinforce current vaccination policies, including the immunization of unvaccinated or incompletely vaccinated individuals from 10 to 39 years of age.

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“…This age range spans several decades, including people who were very likely infected during childhood. Similar trends have been reported in other studies 22,23 .…”

Section: Discussionsupporting

confidence: 92%

Seroprevalence of measles antibodies and factors associated with susceptibility: a national survey in Mexico using a plaque reduction neutralization test

Díaz-Ortega

Ferreira-Guerrero

Cruz-Hervert

et al. 2020

Sci Rep

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show abstract

“…Infants <1 years old have become the most vulnerable population for measles-related complication. The number of cases of measles in infants aged <9 months was high and increases markedly after the infants reach to 6 months 4 , in whom prevention of measles should be considered a priority. The implement of women of child-bearing age vaccination against for MMR vaccine will have benefits for this population.…”

Section: Discussionmentioning

confidence: 99%

“…Vaccination against pertussis and measles was introduced to China in 1960s 4 , 5 , however, a national immunization program first established until 1978. A routine immunization schedule that included 4 basic vaccines against 6 contagious diseases (tuberculosis, diphtheria, neonatal tetanus, whooping cough, poliomyelitis, and measles) was first established 6 .…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, the national immunization schedule was also expanded from 5 vaccines against 7 contagious diseases to 14 vaccines against 15 infectious diseases, mumps and rubella vaccine was introduced into the national immunization schedule at this opportunity 6 . Since 1985, the first immunization of MV was administrated at 9–12 month after birth, which was followed another dosage at 7 years 4 . From 2007, MV was replaced by a measles-rubella vaccine (MRV) at 8 months of age, followed by a MMR vaccine at 18–24 months of age 9 .…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Maternal and Cord Antibodies Specific for Diphtheria, Tetanus, Pertussis, Measles, Mumps and Rubella in Shunyi, Beijing

Meng

Liu

et al. 2018

Sci Rep

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Maternal antibodies contribute to the protection of young infants from infectious diseases during the early life. However, vaccinations for women of child-bearing age are not routine in China. Therefore, we investigated the level of protective immunity against vaccine preventable diseases in pregnant women and newborns in China. A total of 194 paired maternal and cord blood samples were collected in Beijing from 2016 to 2017. Antibodies specific for the antigens covered by diphtheria-tetanus-pertussis (DTP) and measles-mumps-rubella (MMR) vaccine were determined by ELISA (Euroimmun, Lübeck, Germany). The cut off value of ≥0.1 IU/ml (anti-diphtheria), >0.1 IU/ml (anti-tetanus), >40 IU/ml (anti-pertussis toxin), ≥200 IU/l (anti-measles), ≥45 RU/ml (anti-mumps) and ≥10 IU/ml (anti-rubella) were used to assess the percentage of newborns with protective IgG concentrations, respectively. The results revealed that 61.3%, 73.2%, 97.4%, 30.4%, 65.5% and 17.0% of newborns had no protection against diphtheria, tetanus, pertussis, measles, mumps and rubella. Only 1.0% and 23.7% of newborns had protection against all three components of DTP or MMR, respectively. The finding suggested that most of newborns were susceptible to diphtheria, tetanus, pertussis and mumps, almost one-third of this population had no immune protection against measles, and about one-sixth of them were under threat of rubella infection. These data supported the immunization program for DTP and MMR vaccine in women at child-bearing age.

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“…Recent serologic surveys showed that seropositive levels among 20-30 year-old adults were the lowest among the all age groups, with exception of infants too young to vaccinate. [16][17][18] As Ma and colleagues stated, a realistic and possibly important vaccination strategy to target adults is outbreak response immunization (ORI). ORI is recommended in most outbreak settings in middle-and low-income countries.…”

Section: Discussionmentioning

confidence: 99%

Measles outbreak prevention and control among adults: Lessons from an importation outbreak in Yunnan province, China, 2015

Zhao

Zhou

et al. 2018

Human Vaccines & Immunotherapeutics

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Age-related changes in serological susceptibility patterns to measles

Cited by 21 publications

References 15 publications

Seroprevalence of measles antibodies and factors associated with susceptibility: a national survey in Mexico using a plaque reduction neutralization test

Seroprevalence of measles antibodies and factors associated with susceptibility: a national survey in Mexico using a plaque reduction neutralization test

Seroprevalence of Maternal and Cord Antibodies Specific for Diphtheria, Tetanus, Pertussis, Measles, Mumps and Rubella in Shunyi, Beijing

Measles outbreak prevention and control among adults: Lessons from an importation outbreak in Yunnan province, China, 2015

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