Age-related anesthetic effect of ketamine in the chickens

Mousa, Yaareb J.; Al-Zubaidy, M. H. I.; Amin, Sawsan M.

doi:10.33899/ijvs.2020.127100.1458

Cited by 7 publications

(8 citation statements)

References 16 publications

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“…One dose of nefopam was chosen at 18 mg/kg, IM was injected to 6 chickens per H2O or H2O2 groups depending on the previous experiment similar to the analgesic ED100 values of nefopam. The voltage of electro-stimulator apparatus registered pre-and post-thirty min of nefopam therapy to every chicken although the delta volts also noted (6,7,(14)(15)(16)(17)(18)(19). Over the previously mentioned calculation, the percentage contributed to H2O2-induced OS for nefopam's analgesia can be measured by using the delta voltage for H2O and H2O2 groups of chickens.…”

Section: The Antinociception Of Nefopam Against Electrostimulation In Normal and Stressed Chickensmentioning

confidence: 98%

Effect of nefopam in normal chickens and its relationship to hydrogen peroxide-induced oxidative stress

Mousa¹

2021

IJVS

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The objective designated to discover the analgesic effect of nefopam in the normal (non-stressed) chickens and its possible alteration due to hydrogen peroxide (H2O2)induced oxidative stress (OS) in 7-14 day old chickens. The analgesia of nefopam has been increased by 47% in the stressed chickens by measuring the analgesic Median Effective Dose (ED50) value. This value was 9.10 mg/kg, IM in the normal chickens where it became 4.80 mg/kg, IM in stressed chickens. There is a significant rise in the antinociceptive action of nefopam 18 mg/kg, IM by 88% in the stressed group of chickens in comparison with the normal one elicited by an electro-stimulation and formaldehyde 0.05 ml of 0.1% tests for induction of nociception. The observations showed several significant stimulatory modifications in the neurobehaviour when nefopam treated with a subtle dosage 1 mg/kg, IM in the stressed chickens concerning the latency to move, squares crossed and time of the tonic immobility response test. Significant damage was detected in the liver function when nefopam injected at 18 mg/kg, IM in stress chickens in comparison to normal one by 28, 33 and 65% as estimated through Alkaline phosphatase (ALP), Aspartate trans-aminase (AST) and Alanine trans-aminase (ALT) concentrations in the serum, respectively. The sum of data findings indicated that H2O2-induced OS increased the analgesic activity of nefopam in the chickens; despite the changes occur on the neurobehaviour and liver function. The dose of nefopam should be reduced when preparing the therapeutic regimen in the stressed animals.

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Section: The Antinociception Of Nefopam Against Electrostimulation In Normal and Stressed Chickensmentioning

confidence: 98%

Effect of nefopam in normal chickens and its relationship to hydrogen peroxide-induced oxidative stress

Mousa¹

2021

IJVS

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“…So we may have to do drug interaction experiments between two types of drugs. The aim is to reduce the side effects of both drugs by reducing the dose of both and increasing the therapeutic effect (15). In recent years, multiple analgesic techniques have been proposed, combining the additive and synergistic effects of multiple analgesics with fewer adverse effects and offering more effective properties in terms of the potential advantages of using two drugs, improving patient compliance, increasing efficacy while reducing the likelihood of side effects (16).…”

Section: Discussionmentioning

confidence: 99%

Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis

Mohammed¹,

Albadrany²

2022

IJVS

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The study aimed to reveal pregabalin's median effective analgesic dose (ED50) and determine the type of analgesic interaction with tramadol, diclofenac, and paracetamol in chicks. The electrical stimulator device was used to detect pain before and after treatment, and through ascending and descending in doses and depending on the up and down method, the median effective analgesic doses were determined for all drugs used in the study, and then the interaction experiment was conducted at a fixed ratio 0.5:0.5 of pregabalin with each of tramadol, diclofenac and paracetamol of their individual ED50 values, the results were subjected to the isobolographic analysis to determine the type of interaction. Results showed that ED50s for pregabalin, tramadol, diclofenac, and paracetamol in chicks were 156.5, 0.82, 5.65, and 10.74 mg/kg, respectively. Concomitant administration of drugs pregabalin: tramadol, pregabalin: diclofenac and pregabalin: paracetamol at a fixed ratio 0.5:0.5 of their individual ED50 values reduced their ED50s to 36.2:0.18, 64.3:2.3 and 64.3:4.3 mg/kg respectively. Isobolographic analysis showed synergistic analgesic effects of both drugs interaction. The calculated interaction indexes were 0.45, 0.81, and 0.81, respectively. We conclude from the outcomes that the analgesic interaction was synergistic between pregabalin and tramadol significantly, while the analgesic interaction of pregabalin with both diclofenac and paracetamol was also synergistic, but to a lesser extent.

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“…On the sixth day, the open-field box test was conducted in an isolated and quiet room. Each chick was subjected to an immobility test (33)(34)(35).…”

Section: Effect Of Repeated Doses Of Ivermectin For Five Consecutive ...mentioning

confidence: 99%

Acute toxicity events of ivermectin in chicks’ model

Al-Najmawi¹,

Al-Zubaidy²

2022

IJVS

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Ivermectin is a very safe drug; however, there are many studies on its toxic effects in different animals due to sensitivity, misuse, or accidental overdose. This study aimed to further characterize the neurotoxic effects of ivermectin in chicks and identify possible therapeutic strategies for use in cases of ivermectin toxicity. The LD₅₀ of ivermectin was determined by the Dixon method. The acute toxicity signs of ivermectin were induced at doses of 131.5,2629 and 394.5 mg/kg orally. The therapeutic effect of flumazenil on ivermectin poisoning was also studied. Administration of repeated doses of ivermectin for five consecutive days was recorded to measure the neurobehavioral within the open field and tonic immobility test. The oral LD₅₀ of ivermectin was 525.9mg/kg. The acute signs of poisoning on ivermectin-treated chicks were lethargy, ataxia, tremor, diarrhea, recumbency, and death. Flumazenil at a dose of 0.1mg/kg significantly reduced the toxicity signs induced by the ivermectin in chicks, especially tremor and ataxia, and prevented death. The administration of ivermectin at 26.3, 52.6, and 105.2 mg/kg doses led to a significant decrease in motor activity through a significant increase in the time of starting the movement and a decrease in the number of cross lines. We concluded that ivermectin has a neurotoxic effect in chicks when used in high doses; the results also indicate a potential clinical application of flumazenil for treatment side effects and toxicity of ivermectin, as well as ivermectin, has depressant effect in chicks represented by open-field activity.

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Age-related anesthetic effect of ketamine in the chickens

Cited by 7 publications

References 16 publications

Effect of nefopam in normal chickens and its relationship to hydrogen peroxide-induced oxidative stress

Effect of nefopam in normal chickens and its relationship to hydrogen peroxide-induced oxidative stress

Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis

Acute toxicity events of ivermectin in chicks’ model

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