Age dependent incorporation of 14C-DHA into rat brain and body tissues after dosing various 14C-DHA-esters

Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets

“…The greater effi cacy of PC compared with TAG as a carrier for ARA found with 13 C-precursors in previous studies ( 21,51 ) led to speculation that the same would be the case for DHA . Others have considered the relative effi cacy of labeled DHA as carried by TAG and PC in the rat ( 52 ). In a previous study with the radiolabeled ( 14 C) version of the same lipids we considered here, PC-DHA was twice as effi cacious for brain DHA probably only being a minor component of bovine milk protein as base of the formula.…”

Omega-3 long chain fatty acid “bioavailability”: A review of evidence and methodological considerations

“…Amate et al [31], Animal Study 7, compared TAG and PL (arachidonic acid and DHA); Cansell et al [32], Animal Study 8, compared PL emulsion and TAG (n-3 LC-PUFA); Cansell et al [33], Animal Study 9, compared PL emulsion and TAG (n-3 LC-PUFA); Rossmeisl et al [34], Animal Study 10, compared TAG and PL (n-3 LC-PUFA); Graf et al [35], Animal Study 11, compared TAG and PL (DHA); Wijendran et al [36], Animal study 12, compared TAG and PL (arachidonic acid);…”

“…Animal Study 11. In a study by Graf et al [35], male Sprague-Dawley rats (2, 4 and 10 week old) were gavaged with 2 mg 14 C-DHA/kg body weight, either in the form of PL, TAG or PL plus TAG. After 24 h, the distribution of radioactivity in body and brain regions was determined using quantitative whole body autoradiography.…”

“…This topic has not been covered in any detail in the literature; however, there are a few papers that are worth noting. First, in an animal study referred to earlier by Graf et al [35], the incorporation of 14 C-DHA was studied in different rat tissues in rats of 3 different ages (2, 4 and 10-weeks). It is of interest that only in the oldest animals were there significant differences in the uptake of 14 C-DHA in PC form compared with 14 C-DHA in TAG from (2-fold).…”

EPA and DHA Status of South Asian and White Canadians Living in the National Capital Region of Canada

“…Bioavailability of n-3 LCP could also influence tissue fatty acid composition. It has been shown in animals [46][47][48] and in humans [49] that DHA in a phospholipid form is more efficiently absorbed and delivered to tissues compared to DHA in a triglyceride form. In line with these findings, Ramprasath et al [36] showed that in humans, krill oil consumption results in an elevated omega-3 index compared with consumption of fish oil and control oil treatments.…”