Age and the effects of 2-d,l-amino-5-phosphonovalerate in an area of the chick forebrain which is essential for early learning

Bradley, P.M.; Burns, B. Delisle; King, Theodore M.; Webb, Alistair I.

doi:10.1016/0006-8993(95)00897-y

Cited by 10 publications

(2 citation statements)

References 18 publications

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“…Outside the visual system, NMDAr blockade has also been shown to have suppressive effects on spontaneous activity. In the spinal cord and forebrain of developing chicks (Bradley et al, 1995;Chub and O'Donovan, 1998) and in the spinal cord and hippocampus of mammals (Corradetti et al, 1988;Abdul-Razzak et al, 1994), APV has been found to suppress spontaneous activity. There is also evidence that NMDArs regulate activity levels and responsiveness in the adult visual system.…”

Section: Nmdar Function At Nonoptic Synapses Regulates Spontaneous Tementioning

confidence: 99%

N-methyl-D-aspartate receptors strongly regulate postsynaptic activity levels during optic nerve regeneration

Kolls

Meyer

2013

Journal of Neuroscience Research

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During development, neuronal activity is used as a cue to guide synaptic rearrangements to refine connections. Many studies, especially in the visual system, have shown that the N-methyl-D-aspartate receptor (NMDAr) plays a key role in mediating activity-dependent refinement through long-term potentiation (LTP)-like processes. Adult goldfish can regenerate their optic nerve and utilize neuronal activity to generate precise topography in their projection onto tectum. Although the NMDAr has been implicated in this process, its precise role in regeneration has not been extensively studied. In examining NMDAr function during regeneration, we found salient differences compared with development. By using field excitatory postsynaptic potential (fEPSP) recordings, the contribution of the NMDAr at the primary optic synapse was measured. In contrast to development, no increase in NMDAr function was detectable during synaptic refinement. Unlike development, LTP could not be reliably elicited during regeneration. Unexpectedly, we found that NMDAr exerted a major effect on regulating ongoing tectal (postsynaptic) activity levels during regeneration. Blocking NMDAr strongly suppressed spontaneous activity during regeneration but had no significant effect in the normal projection. This difference could be attributed to an occlusion effect of strong optic drive in the normal projection, which dominated ongoing tectal activity. During regeneration, this optic drive is largely absent. Optic nerve stimulation further indicated that the NMDAr had little effect on the ability of optic fibers to evoke early postsynaptic impulse activity but was important for late network activity. These results indicate that, during regeneration, the NMDAr may play a critical role in the homeostatic regulation of ongoing activity and network excitability.

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Section: Nmdar Function At Nonoptic Synapses Regulates Spontaneous Tementioning

confidence: 99%

N-methyl-D-aspartate receptors strongly regulate postsynaptic activity levels during optic nerve regeneration

Kolls

Meyer

2013

Journal of Neuroscience Research

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“…We can simply say that both IMHV and LPO, two major critical regions for passive avoidance memory, also contain excitatory glutamatergic synapses that undergo LTP under certain experimental conditions (Bradley et al, 1991;Matsushima and Aoki 1995). We may further stress a close parallelism between memory formation and LTP in terms of common pharmacological treatments effective in suppressing both events; such as selective blockers of NMDA-type glutamate receptors or dopamine D1 receptors (Bradley et al, 1995;Matsushima and Yanagihara 1998;Kabai et al, unpublished data). Causal link among molecular, cellular and behavioral events awaits direct answers.…”

Section: Functional Link Among Iegs Synaptic Plasticity and Memory Fmentioning

confidence: 99%

Expression of Transcription FactorZENK(zif/268) in Telencephalon of Quail Chicks after Induced Seizure and Passive Avoidance Training

Yanagihara¹,

Koga²,

Matsushima³

2000

Zoological Science

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Electrophysiological correlates of prior training: an in vitro study of an area of the avian brain which is essential for early learning

Bradley¹,

Burns²,

King³

et al. 1996

Brain Research

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Age and the effects of 2-d,l-amino-5-phosphonovalerate in an area of the chick forebrain which is essential for early learning

Cited by 10 publications

References 18 publications

N-methyl-D-aspartate receptors strongly regulate postsynaptic activity levels during optic nerve regeneration

N-methyl-D-aspartate receptors strongly regulate postsynaptic activity levels during optic nerve regeneration

Expression of Transcription FactorZENK(zif/268) in Telencephalon of Quail Chicks after Induced Seizure and Passive Avoidance Training

Electrophysiological correlates of prior training: an in vitro study of an area of the avian brain which is essential for early learning

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