Agarose Hydrogel Characterization for Regenerative Medicine Applications: Focus on Engineering Cartilage

Roach, Brendan L.; Nover, A; Ateshian, Gerard A.; Hung, Clark T.

doi:10.1002/9781119126218.ch16

Cited by 19 publications

(12 citation statements)

References 88 publications

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“…The mechanical behavior of agarose is comparable to articular cartilage upon static or dynamic loading [71,72]. Since cartilage and agarose are both hydrated materials, they exhibit straindependent hydraulic permeability, which means that resistance to water transportation through the hydrogel increases with the increase of applied deformation (and the collapse of the pores) [73].…”

Section: Agarose Propertiesmentioning

confidence: 99%

Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering

et al. 2020

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The lack of adequate blood/lymphatic vessels as well as low-potential articular cartilage regeneration underlines the necessity to search for alternative biomaterials. Owing to their unique features, such as reversible thermogelling behavior and tissue-like mechanical behavior, agarose-based biomaterials have played a key role in cartilage tissue repair. Accordingly, the need for fabricating novel highly efficient injectable agarose-based biomaterials as hydrogels for restoration of injured cartilage tissue has been recognized. In this review, the resources and conspicuous properties of the agarose-based biomaterials were reviewed. First, different types of signals together with their functionalities in the maintenance of cartilage homeostasis were explained. Then, various cellular signaling pathways and their significant role in cartilage tissue engineering were overviewed. Next, the molecular structure and its gelling behavior have been discussed. Eventually, the latest advancements, the lingering challenges, and future ahead of agarose derivatives from the cartilage regeneration perspective have been discussed.

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Section: Agarose Propertiesmentioning

confidence: 99%

Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering

et al. 2020

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“…Agarose is a natural polymer that exhibits thermo-reversible gelation behavior similar to HPMC [ 47 ], while eliciting robust and inert properties ( Table 1 ) [ 48 ]. Agarose hydrogel is widely used as a scaffold in tissue engineering due to excellent biocompatibility and adjustable mechanical properties [ 47 ]. However, agarose hydrogel lacks in cell adhesiveness and has poor biodegradability [ 47 ].…”

Section: Production Methods Of Phage-delivering Hydrogelsmentioning

confidence: 99%

“…Agarose hydrogel is widely used as a scaffold in tissue engineering due to excellent biocompatibility and adjustable mechanical properties [ 47 ]. However, agarose hydrogel lacks in cell adhesiveness and has poor biodegradability [ 47 ]. To overcome this drawback, agarose is often blended with other polymers [ 48 , 60 ].…”

Section: Production Methods Of Phage-delivering Hydrogelsmentioning

confidence: 99%

Bacteriophage-Delivering Hydrogels: Current Progress in Combating Antibiotic Resistant Bacterial Infection

Kim

Chang

Morales³

et al. 2021

Antibiotics

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Antibiotic resistance remains as an unresolved global challenge in the health care system, posing serious threats to global health. As an alternative to antibiotics, bacteriophage (phage) therapy is rising as a key to combating antibiotic-resistant bacterial infections. In order to deliver a phage to the site of infection, hydrogels have been formulated to incorporate phages, owing to its favorable characteristics in delivering biological molecules. This paper reviews the formulation of phage-delivering hydrogels for orthopedic implant-associated bone infection, catheter-associated urinary tract infection and trauma-associated wound infection, with a focus on the preparation methods, stability, efficacy and safety of hydrogels as phage carriers.

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“…Agarose is another temperature-responsive biomaterial whose cross-linking mechanism is characterised by the aggregation of double helical structures while the temperature decreases from melting point (∼85 °C) to the gel point (∼ 35 °C) [200].…”

Section: Physical Cross-linkingmentioning

confidence: 99%

Development of human liver extracellular matrix hydrogel for three dimensional cell culture and cell transplantation

Frenguelli¹,

Al‐Akkad²,

Crowley³

et al. 2017

Journal of Hepatology

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Agarose Hydrogel Characterization for Regenerative Medicine Applications: Focus on Engineering Cartilage

Cited by 19 publications

References 88 publications

Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering

Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering

Bacteriophage-Delivering Hydrogels: Current Progress in Combating Antibiotic Resistant Bacterial Infection

Development of human liver extracellular matrix hydrogel for three dimensional cell culture and cell transplantation

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