Ag Nanoparticles Stabilized on Magnetic Carboxymethyl Lignin: Synthesis, Characterization and its Performance in the N-Acylation Reactions and Investigation of its Antioxidant and Anti-Human Colorectal Cancer Application

Herein, the bio-inspired synthesis of Au nanoparticles (NPs) adorned Thymbra spicata extract functionalized Fe3O4 NPs as a novel magnetic nanocomposite has been demonstrated. The plant phytochemicals act as a natural and non-toxic reductant as well as the in situ stabilizing agent of the NPs. The Au–Thymbra@Fe3O4 composite was characterized over a range of advance physicochemical techniques like fourier transformed infra red (FT-IR) spectroscopy, scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray spectroscopy, elemental mapping, vibrating sample magnetometer and inductively coupled plasma-optical emission spectroscopy. Toward its bio-applications, the material was employed investigating the cytotoxicity and leukemic potential against several related cell lines, viz, 32D-FLT3-ITD, HL-60/vcr (acute myeloid leukemia) and MOLT-3, TALL-104 (acute lymphoblastic leukemia) in vitro, following MTT assay. The corresponding inhibition concentration by 50% level, i.e., IC50 were evaluated as 125, 150, 133 and 170 µg/mL, respectively. In addition, the Au–Thymbra@Fe3O4 nanocomposite proved to be a good antioxidant, which was validated from DPPH radical quenching assay and a significantly good IC50 value.

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Ag Nanoparticles Stabilized on Magnetic Carboxymethyl Lignin: Synthesis, Characterization and its Performance in the N-Acylation Reactions and Investigation of its Antioxidant and Anti-Human Colorectal Cancer Application

Cited by 3 publications

References 56 publications

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Thymbra spicataleaf extract driven biogenic synthesis of Au/Fe₃O₄nanocomposite and its bio-application in the treatment of different types of leukemia

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Ag Nanoparticles Stabilized on Magnetic Carboxymethyl Lignin: Synthesis, Characterization and its Performance in the N-Acylation Reactions and Investigation of its Antioxidant and Anti-Human Colorectal Cancer Application

Cited by 3 publications

References 56 publications

Supported gold nanoparticles on lignosulfonate coated magnetic nanoparticles: Investigation of its catalytic efficiency in the reductive formylation of nitroarenes

Supported gold nanoparticles on lignosulfonate coated magnetic nanoparticles: Investigation of its catalytic efficiency in the reductive formylation of nitroarenes

Bio-supported of silver nanoparticles over magnetic nanoparticles: Assessmentof its catalytic reaction for the propargylamines synthesis and study of its antioxidant and anti-colon cancer consequences

Thymbra spicataleaf extract driven biogenic synthesis of Au/Fe3O4nanocomposite and its bio-application in the treatment of different types of leukemia

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Thymbra spicataleaf extract driven biogenic synthesis of Au/Fe₃O₄nanocomposite and its bio-application in the treatment of different types of leukemia