Ag-Conjugated graphene quantum dots with blue light-enhanced singlet oxygen generation for ternary-mode highly-efficient antimicrobial therapy

Yu, Yunjian; Mei, Lin; Shi, Yanmei; Zhang, Xinge; Cheng, Kesong; Cao, Fengyi; Jia, Xu; Li, Xiumin; Xu, Zhenlong

doi:10.1039/c9tb02300c

Cited by 63 publications

(47 citation statements)

References 51 publications

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“…Different studies proposed low or no antimicrobial activity of GQDs against gram-positive and gram-negative bacteria in the absence of light exposure, whereas curcumin showed a dosedependent antimicrobial activity (24)(25)(26). The potential slight antibacterial activity of GQDs is due to the fact that GQDs may disrupt bacterial cell membrane (27,28). The potential mechanism behind curcumin's antimicrobial activity is believed to be the production and accumulation of intracellular ROS that cause damage to bacterial cell membrane and cell death (29).…”

Section: Discussionmentioning

confidence: 99%

Potentiation of Antimicrobial Photodynamic Therapy by Curcumin‐loaded Graphene Quantum Dots

Mushtaq

Yasin

Saleem³

et al. 2021

Photochem & Photobiology

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Increasing resistance to existing antibiotics by microbes is currently the biggest dilemma. Antimicrobial photodynamic therapy is a promising alternative for the treatment of multidrug-resistant infections. The aim of the current study was to fabricate graphene quantum dots loaded with curcumin as photosensitizer for improved antimicrobial photodynamic therapy. The study involved fabrication of blank and curcumin-loaded graphene quantum dots, their characterizations (TEM, UV-visible and fluorescence emission spectra), cytotoxicity assay, ROS assay and investigation of enhanced antimicrobial photodynamic effect against resistant microbes. The fabrication of blank and loaded graphene quantum dots was confirmed by the observation of peak shift and changes in peak intensity of blank graphene quantum dots, curcumin alone compared with curcumin-loaded graphene quantum dots in UV-visible and fluoresce emission spectra. Cytotoxicity assay showed that 100 µM concentration was not toxic to NIH/3t3 fibroblasts. In ROS assay, the curcumin-loaded formulation showed three-fold increase in ROS production. Blue-light (405 nm) irradiance of 30 J cm À2 and photosensitizer concentration of 100 µM showed ~3.5 log 10 enhanced CUF reduction against Pseudomonas aeruginosa, MRSA, Escherichia coli and Candida albicans. In conclusion, curcumin-loaded graphene quantum dots shoed enhanced antimicrobial photodynamic effects and can be used as an alternative effective treatment for resistant infections.

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Section: Discussionmentioning

confidence: 99%

Potentiation of Antimicrobial Photodynamic Therapy by Curcumin‐loaded Graphene Quantum Dots

Mushtaq

Yasin

Saleem³

et al. 2021

Photochem & Photobiology

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“…Redox-responsive Ce 6 /GQDs significantly inhibited HeLa cell growth. Furthermore, GQD’s combination therapy is comparable to other SCPs such as chemotherapy with DOX, 128 immunotherapy, 129 PTT 130 , 131 and numerous combined therapies, all of which have been reviewed. 22 , 132 …”

Section: Two-dimensional (2d) Scpsmentioning

confidence: 99%

Strategies to Improve Photodynamic Therapy Efficacy of Metal-Free Semiconducting Conjugated Polymers

Sun¹,

Xue²,

Zhang³

2022

IJN

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Photodynamic therapy (PDT) is a noninvasive therapy for cancer and bacterial infection. Metal-free semiconducting conjugated polymers (SCP S ) with good stability and optical and electrical properties are promising photosensitizers (PSs) for PDT compared with traditional small-molecule PSs. This review analyzes the latest progress of strategies to improve PDT effect of linear, planar, and three-dimensional SCP S , including improving solubility, adjusting conjugated structure, enhancing PS-doped SCPs, and combining therapies. Moreover, the current issues, such as hypoxia, low penetration, targeting and biosafety of SCP S, and corresponding strategies, are discussed. Furthermore, the challenges and potential opportunities on further improvement of PDT for SCPs are presented.

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“…In another example, AgNPs were combined with Graphene Quantum Dots (GQD) [129] . GQDs are zero-dimension carbon nanomaterials that exhibit excellent photoluminescence, water dispersibility, biocompatibility, and low cytotoxicity properties, as well as the capacity to photogenerate ROS.…”

Section: Graphene Quantum Dotsmentioning

confidence: 99%

Latest trends on photodynamic disinfection of Gram-negative bacteria: photosensitizer’s structure and delivery systems

Maldonado-Carmona

Ouk

Leroy‐Lhez

2021

Photochem Photobiol Sci

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Ag-Conjugated graphene quantum dots with blue light-enhanced singlet oxygen generation for ternary-mode highly-efficient antimicrobial therapy

Abstract: A broad-spectrum antibacterial system was produced in which silver nanoparticle-conjugated graphene quantum dots were utilised as a blue light-enhanced nanotherapeutic for efficient ternary-mode antimicrobial therapy.

Cited by 63 publications

References 51 publications

Potentiation of Antimicrobial Photodynamic Therapy by Curcumin‐loaded Graphene Quantum Dots

Potentiation of Antimicrobial Photodynamic Therapy by Curcumin‐loaded Graphene Quantum Dots

Strategies to Improve Photodynamic Therapy Efficacy of Metal-Free Semiconducting Conjugated Polymers

Latest trends on photodynamic disinfection of Gram-negative bacteria: photosensitizer’s structure and delivery systems

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