Latest trends on photodynamic disinfection of Gram-negative bacteria: photosensitizer’s structure and delivery systems

Maldonado-Carmona, Nidia; Ouk, Tan‐Sothéa; Leroy‐Lhez, Stéphanie

doi:10.1007/s43630-021-00128-5

Cited by 16 publications

(6 citation statements)

References 156 publications

(183 reference statements)

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“…Although this is not applicable for systemic infections, antimicrobial PDT has been explored for the treatment of localized infections, such as those resulting from burn wounds, diabetic foot ulcers and skin and urinary tract infections [220][221][222] . For an overview on the latest progress in photosensitizer design in antimicrobial PDT, the reader is referred to a recent review 223 . A potential advantage of antimicrobial PDT is that it is a multifaceted attack against pathogens that is not limited to a singular molecular target.…”

Section: Photoactivated Metal Complexesmentioning

confidence: 99%

Metals to combat antimicrobial resistance

et al. 2023

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Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions have a long history of antimicrobial activity and have received increasing attention in recent years owing to the rise of antimicrobial resistance. The search for antibacterial agents now encompasses metal ions, nanoparticles and metal complexes with antimicrobial activity (‘metalloantibiotics’). Although yet to be advanced to the clinic, metalloantibiotics are a vast and underexplored group of compounds that could lead to a much-needed new class of antibiotics. This Review summarizes recent developments in this growing field, focusing on advances in the development of metalloantibiotics, in particular, those for which the mechanism of action has been investigated. We also provide an overview of alternative uses of metal complexes to combat bacterial infections, including antimicrobial photodynamic therapy and radionuclide diagnosis of bacterial infections.

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Section: Photoactivated Metal Complexesmentioning

confidence: 99%

Metals to combat antimicrobial resistance

et al. 2023

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“…6 It has the potential to treat a wide variety of local and chronic infections responsible for long-term hospitalization. 7 PDT has also shown to trigger an immune response, making a-PDT well adapted for local wound disinfection. 8 Nevertheless, several issues remain to be solved for safe and efficient a-PDT applications to a broad range of pathogens found in infections.…”

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confidence: 99%

“…It has shown promising results toward bacteria, viruses, and fungi by the oxidative damage generated by ROS to cellular constituents such as lipids, proteins, nucleic acids, and polysaccharides. , The strength of a-PDT resides in the low propensity of microorganisms to develop resistance to a multitarget treatment and its effectiveness against both sensitive and multiresistant bacteria . It has the potential to treat a wide variety of local and chronic infections responsible for long-term hospitalization . PDT has also shown to trigger an immune response, making a-PDT well adapted for local wound disinfection .…”

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confidence: 99%

“…Nevertheless, this low energy range of excitation requires an amphiphilic PS designed to have strong near IR absorption and singlet oxygen generation capacity. Although bacteriochlorins and phthalocyanines have propensity to absorb in the NIR, their drawbacks such as reduced stability and photostability for bacteriochlorins and high hydrophobicity for phthalocyanines must be overcome for a-PDT applications. ,, Chemical modifications of their structure, in particular, with the addition of cationic groups to promote water solubility and electrostatic attraction to the negative bacterial wall have proven in some cases effective for significant photodynamic inactivation of Gram-positive and Gram-negative bacteria, with limited toxicity on host cells. − Nevertheless, phthalocyanine and bacteriochlorin derivatives associated with bacterial targeting units have not received much attention yet. One of the rare examples is a boronic acid-functionalized Si(IV) phthalocyanine with absorption extending in the NIR that can bind to the polysaccharides of the bacterial cell membrane .…”

mentioning

confidence: 99%

“…coli in planktonic and biofilm cultures was achieved upon irradiation at wavelengths above 610 nm from a polychromic light source. Another strategy for near IR absorption is the use of metal-based nanoparticles consisting of different components that enable, by up-conversion or energy-transfer processes, to generate the PS in the excited state . These nanomaterials have nevertheless limitations regarding their applicability because of their potential toxicity and the difficulty in gauging the drug-dose needed for an optimal therapeutic outcome.…”

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Antibacterial Photodynamic Therapy in the Near-Infrared Region with a Targeting Antimicrobial Peptide Connected to a π-Extended Porphyrin

et al. 2022

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The increase of antimicrobial resistance to conventional antibiotics is worldwide a major health problem that requires the development of new bactericidal strategies. Antimicrobial photodynamic therapy (a-PDT) that generates reactive oxygen species acting on multiple cellular targets is unlikely to induce bacterial resistance. This localized treatment requires, for safe and efficient treatment of nonsuperficial infections, a targeting photosensitizer excited in the near IR. To this end, a new conjugate consisting of an antimicrobial peptide linked to a π-extended porphyrin photosensitizer was designed for a-PDT. Upon irradiation at 720 nm, the conjugate has shown at micromolar concentration strong bactericidal action on both Gram-positive and Gram-negative bacteria. Moreover, this conjugate allows one to reach a low minimum bactericidal concentration with near IR excitation without inducing toxicity to skin cells.

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Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy

He,

Feng,

Hao

et al. 2024

Adv Funct Materials

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Antibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic therapy (aSDT) utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species (ROS) for antibacterial treatment under the stimulation of light/ultrasound, which have the characteristics of broad‐spectrum antibacterial properties, low drug‐resistance, and effective targeting of infected tissues. Nanomaterials in aPDT/aSDT are primarily used as nano‐sensitizers or nano‐carriers of sensitizers. They enhance the stability and permeability of sensitizers, improve targeting of sensitizers, strengthen photodynamic/sonodynamic properties of sensitizers (modification of sensitizers absorption efficiency and light/ultrasonic response stress by modulation of nanoparticle shape, size, and structure). Also, they improve modifiability of sensitizers (controlling the release rate and time of the sensitizer as needed to optimize the therapeutic effect), enhance programmability and multifunctionality of sensitizers (flexible application of nanotechnology for designing sensitizers with multiple functions, such as drug delivery, targeted therapy, and therapeutic monitoring), and expand possibilities for combination therapies (the nano‐carriers can be loaded with other therapeutic agents, enabling combination therapies). Nanomaterials are expected to further promote the development of aPDT/aSDT and achieve improved antibacterial effects. This review summarizes the progress in nanomaterials in aPDT/aSDT in recent years and based on the current development strategies to provide a theoretical reference for the application of nanomaterials in aPDT/aSDT.

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Latest trends on photodynamic disinfection of Gram-negative bacteria: photosensitizer’s structure and delivery systems

Cited by 16 publications

References 156 publications

Metals to combat antimicrobial resistance

Metals to combat antimicrobial resistance

Antibacterial Photodynamic Therapy in the Near-Infrared Region with a Targeting Antimicrobial Peptide Connected to a π-Extended Porphyrin

Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy

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