AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract

Qu, Yingmin; Wang, Zuobin; Zhao, Feihu; Liu, Jinyun; Zhang, Wenxiao; Li, Jingmei; Song, Zhengxun; Xu, Hongmei

doi:10.1016/j.micron.2017.10.003

Cited by 21 publications

(15 citation statements)

References 26 publications

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“…Important herbs that have been studied with regard to BUFA include Radix astragalus (huang qi), and its ability to enhance the immune system (Denzer et al, 2006); Atractylodes rhizome (bai zhu), which increases lymphocyte proliferation and stimulates the immune system (Son et al, 2017); and Radix codonopsis (dang shen), which increases red blood cells and assists in T cell formation (He et al, 2015b). Additionally, American ginseng or Panacis quinquefolii radix (xi yang shen) has been found to inhibit cancer of the liver (Qu et al, 2018), colon (Yang et al, 2016), and breast cancer (Yonghe, 2004).…”

Section: Bufa (Formulas and Herbs That Tonify)mentioning

confidence: 99%

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Hoffman

et al. 2020

Front. Pharmacol.

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Traditional Chinese medicine is an accepted and integral part of clinical cancer management alongside Western medicine in China. However, historically TCM physicians were unaware of the chemical constituents of their formulations, and the specific biological targets in the body. Through HPLC, flow cytometry, and other processes, researchers now have a much clearer picture of how herbal medicine works in conjunction with the immune system in cancer therapy. Among them, the regulation of tumor-related T cells plays the most important role in modulating tumor immunity by traditional Chinese medicine. Encouraging results have been well-documented, including an increase in T cell production along with their associated cytokines, enhanced regulation of Tregs and important T cell ratios, the formation and function of Tregs in tumor microenvironments, and the promotion of the number and function of normal T Cells to reduce conventional cancer therapy side effects. Chinese herbal medicine represents a rich field of research from which to draw further inspiration for future studies. While promising agents have already been identified, the vast majority of Chinese herbal mechanisms remain undiscovered. In this review, we summarize the effects and mechanisms of specific Chinese herbs and herbal decoctions on tumor related T cells.

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Section: Bufa (Formulas and Herbs That Tonify)mentioning

confidence: 99%

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Hoffman

et al. 2020

Front. Pharmacol.

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“…Water extract of AG (20, 40, 60, and 80 mg/mL) changed morphological and mechanical properties of human hepatocellular carcinoma SMMC-7721 cells that displayed an increased susceptibility to apoptosis [96]. AG was also found to display anti-cancer activity in human breast cancer MCF-7 cells through inhibition of their proliferation underlined by alterations in the mitogen-activated protein kinase (MAPK) signalling pathway [97].…”

Section: Pro-health Effects Of American Ginsengmentioning

confidence: 99%

American Ginseng (Panax quinquefolium L.) as a Source of Bioactive Phytochemicals with Pro-Health Properties

et al. 2019

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Panax quinquefolium L. (American Ginseng, AG) is an herb characteristic for regions of North America and Asia. Due to its beneficial properties it has been extensively investigated for decades. Nowadays, it is one of the most commonly applied medical herbs worldwide. Active compounds of AG are ginsenosides, saponins of the glycosides group that are abundant in roots, leaves, stem, and fruits of the plant. Ginsenosides are suggested to be primarily responsible for health-beneficial effects of AG. AG acts on the nervous system; it was reported to improve the cognitive function in a mouse model of Alzheimer’s disease, display anxiolytic activity, and neuroprotective effects against neuronal damage resulting from ischemic stroke in animals, demonstrate anxiolytic activity, and induce neuroprotective effects against neuronal damage in ischemic stroke in animals. Administration of AG leads to inhibition of hypertrophy in heart failure by regulation of reactive oxygen species (ROS) in mice as well as depletion of cardiac contractile function in rats. It also has an anti-diabetic and anti-obesity potential as it increases insulin sensitivity and inhibits formation of adipose tissue. AG displays anti-cancer effect by induction of apoptosis of cancer cells and reducing local inflammation. It exerts antimicrobial effects against several pathogenic strains of bacteria. Therefore, AG presents a high potential to induce beneficial health effects in humans and should be further explored to formulate precise nutritional recommendations, as well as to assess its value in prevention and therapy of some disorders, including cancer.

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“…Additionally, the expanded surface roughness and elastic modulus of cells under the AG extract concentrate treatment have demonstrated that the apoptosis of hepatocellular carcinoma cells can be enhanced by AG extract concentrate. This will provide a vital implication for hepatocellular carcinoma treatment and novel drug development [155].…”

Section: Effects On Cancermentioning

confidence: 99%

Pharmacological and Clinical Efficacy of American Ginseng (<i>Panax Quinquefolius</i>): A Mini Review

Eric¹,

Li²,

Wang³

2019

IJCM

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American Ginseng (Panax quinquefolius, AG) is a standout amongst the most perceived herbal botanicals in Oriental Medicine and the alternative healthcare market. In spite of the fact that AG is not as broadly studied as Panax Ginseng, none the less, AG is one of the best-selling herbs in the world market, and has gathered expanding attention from researchers as of late. AG is grown in the United States of America, Canada, and The People's Republic of China, on subject of AG industry and quality standards Wisconsin Ginseng is considered to be the gold standard for the highest quality grown worldwide. AG has been farmed in Wisconsin, U.S., for more than 100 years, dating back to the 1800's which birthed the artificially propagated industry. Today, Wisconsin Ginseng farmers account for 95 percent of the total cultivated AG production of the United States which continues to attract the studies of researcher professionals to the environmentally clean and regulated grown Wisconsin source of origin. Ongoing studies have demonstrated that through the numerous unregulated cultivated procedures that AG is grown, fungal molds, pesticides, and various metals and residues have contaminated the crops. Scientific investigations of AG in the past decade have increased drastically due to the increasing demand of herbal derived biomedicines from natural botanical plant sources that have demonstrated significant potential in clinical efficacy of important diseases. AG Past studies demonstrated have shown ginseng saponins called ginsenosides are the major active constituents in AG. The investigations of AG were relatively limited in the previous decade, but some encouraging advances have been accomplished in understanding the chemistry, pharmacology and structure-function relationship of AG and its clinical efficacy. In this manner, we review pharmacological effects of the ginsenosides, also the clinical efficacy on the cardiovascular system, immune system, and nervous system as well as metabolism and anti-cancer effects. Concentrating on the clinical evidence has indicated particular effectiveness in specific diseases, such as diabetes mellitus, arterial stiffness, neurocognitive disorders, and cancer fatigue as a recommended adjunct treatment along with supplementing conventional therapy.

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AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract

Cited by 21 publications

References 26 publications

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

American Ginseng (Panax quinquefolium L.) as a Source of Bioactive Phytochemicals with Pro-Health Properties

Pharmacological and Clinical Efficacy of American Ginseng (<i>Panax Quinquefolius</i>): A Mini Review

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AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract

Cited by 21 publications

References 26 publications

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

American Ginseng (Panax quinquefolium L.) as a Source of Bioactive Phytochemicals with Pro-Health Properties

Pharmacological and Clinical Efficacy of American Ginseng (&lt;i&gt;Panax Quinquefolius&lt;/i&gt;): A Mini Review

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Pharmacological and Clinical Efficacy of American Ginseng (<i>Panax Quinquefolius</i>): A Mini Review