Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women

Cercamondi, Colin I.; Egli, Ines; Ahouandjinou, Ella; Dossa, Romain; Zeder, Christophe; Salami, Lamidhi; Tjalsma, Harold; Wiegerinck, Erwin T.; Tanno, Toshihiko; Hurrell, Richard F.; Hounhouigan, Joseph D.; Zimmermann, Michael

doi:10.3945/ajcn.2010.30051

Cited by 106 publications

(126 citation statements)

References 63 publications

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“…[35][36][37][38] Our study confirms that iron-deficiency anemia is prevalent in south-central Cô te d'Ivoire. 6,39 However, our results also emphasize the lack of robust markers for estimating iron deficiency in populations where malaria and more generally, inflammation are widespread. Both ferritin and sTfR showed a significant correlation with AGP and CRP.…”

Section: Discussionmentioning

confidence: 64%

Etiology of Anemia Among Infants, School-Aged Children, and Young Non-Pregnant Women in Different Settings of South-Central Côte d'Ivoire

Righetti¹,

Koua²,

Adiossan³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. Anemia affects one-quarter of the world's population, but its etiology remains poorly understood. We determined the prevalence of anemia and studied underlying risk factors in infants (6-23 months), young school-aged children (6-8 years), and young non-pregnant women (15-25 years) in south-central Cô te d'Ivoire. Blood, stool, and urine samples were subjected to standardized, quality-controlled methods. We found high prevalence of anemia, malaria, inflammation, and deficiencies of iron, riboflavin, and vitamin A but low prevalence and intensities of soil-transmitted helminth and schistosome infections. Multivariate regression analysis revealed significant associations between anemia and Plasmodium falciparum for infants, inflammation for school-aged children, and cellular iron deficiency for both school-aged children and non-pregnant women. Women with riboflavin deficiency had significantly lower odds of anemia. Our findings call for interventions to protect infants from malaria, improved intake of dietary iron, better access to health care, and health education.

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Section: Discussionmentioning

confidence: 64%

Etiology of Anemia Among Infants, School-Aged Children, and Young Non-Pregnant Women in Different Settings of South-Central Côte d'Ivoire

Righetti¹,

Koua²,

Adiossan³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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“…Possibly, these increased hepcidin concentrations might be advantageous in the protection against extracellular growing microorganisms by decreasing the extracellular supply of iron. On the other hand, increased hepcidin concentrations may lead to iron deficiency and blunt the efficacy of iron fortification programs by decreasing iron absorption (157 ). Conversely, the increased hepcidin concentrations seen with inflammation might increase the virulence of bacteria that depend on macrophage iron for their proliferation within these cells (e.g., Salmonella and Mycobacteria spp.).…”

Section: Disorders Associated With Hepcidin Excessmentioning

confidence: 98%

Hepcidin in Human Iron Disorders: Diagnostic Implications

et al. 2011

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BACKGROUND:The peptide hormone hepcidin plays a central role in regulating dietary iron absorption and body iron distribution. Many human diseases are associated with alterations in hepcidin concentrations. The measurement of hepcidin in biological fluids is therefore a promising tool in the diagnosis and management of medical conditions in which iron metabolism is affected.CONTENT: We describe hepcidin structure, kinetics, function, and regulation. We moreover explore the therapeutic potential for modulating hepcidin expression and the diagnostic potential for hepcidin measurements in clinical practice.

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“…[5][6][7][8] The loss of functional ferroportin causes the inhibition of dietary iron absorption via enterocytes and promotes sequestration of iron in reticuloendothelial cells with a net effect of iron restriction from pathogens. 6,9,10 Iron restriction is important to the host's defensive response across multiple stages of malaria infection. Numerous in vitro and in vivo studies confirm that reducing iron availability through application of iron-chelating agents is an effective method to stunt the proliferation of parasites.…”

Section: Introductionmentioning

confidence: 99%

Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study

Brickley

Spottiswoode

Kabyemela

et al. 2016

The American Journal of Tropical Medicine and Hygiene

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Abstract. Hepcidin, the master regulator of bioavailable iron, is a key mediator of anemia and also plays a central role in host defense against infection. We hypothesized that measuring hepcidin levels in cord blood could provide an early indication of interindividual differences in iron regulation with quantifiable implications for anemia, malaria, and mortality-related risk. Hepcidin concentrations were measured in cord plasma from a birth cohort (N = 710), which was followed for up to 4 years in a region of perennial malaria transmission in Muheza, Tanzania (2002Tanzania ( -2006. At the time of delivery, cord hepcidin levels were correlated with inflammatory mediators, iron markers, and maternal health conditions. Hepcidin levels were 30% (95% confidence interval [CI]: 12%, 44%) lower in children born to anemic mothers and 48% (95% CI: 11%, 97%) higher in placental malaria-exposed children. Relative to children in the lowest third, children in the highest third of cord hepcidin had on average 2.5 g/L (95% CI: 0.1, 4.8) lower hemoglobin levels over the duration of follow-up, increased risk of anemia and severe anemia (adjusted hazard ratio [HR]

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Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women

Cited by 106 publications

References 63 publications

Etiology of Anemia Among Infants, School-Aged Children, and Young Non-Pregnant Women in Different Settings of South-Central Côte d'Ivoire

Etiology of Anemia Among Infants, School-Aged Children, and Young Non-Pregnant Women in Different Settings of South-Central Côte d'Ivoire

Hepcidin in Human Iron Disorders: Diagnostic Implications

Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study

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