Aeruginascin, a Trimethylammonium Analogue of Psilocybin from the Hallucinogenic Mushroom<i>Inocybe aeruginascens</i>

Jensen, Niels H.; Gartz, J.; Laatsch, Hartmut

doi:10.1055/s-2006-931576

Cited by 48 publications

(39 citation statements)

References 8 publications

(19 reference statements)

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“…83 Thin-layer chromatography was reported as an appropriate method of psilocybin/psilocin isolation using cellulose plates or silica gel plates. 60,71,87,[111][112][113] The methods of paper chromatography 108 or bidirectional paper chromatography 74,75 were also used for separation. A method of psilocybin isolation using preparative thin-layer chromatography on silica gel plates followed by reextraction was developed.…”

Section: Methods Of Qualitative Analysis and Isolationmentioning

confidence: 99%

Fungal Hallucinogens Psilocin, Ibotenic Acid, and Muscimol

Stebelska

2013

Therapeutic Drug Monitoring

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Psychoactive drugs of fungal origin, psilocin, ibotenic acid, and muscimol among them have been proposed for recreational use and popularized since the 1960s, XX century. Despite their well-documented neurotoxicity, they reached reputation of being safe and nonaddictive. Scientific efforts to find any medical application for these hallucinogens in psychiatry, psychotherapy, and even for religious rituals support are highly controversial. Even if they show any healing potential, their usage in psychotherapy is in some cases inadequate and may additionally harm seriously suffering patients. Hallucinogens are thought to reduce cognitive functions. However, in case of indolealkylamines, such as psilocin, some recent findings suggest their ability to improve perception and mental skills, what would motivate the consumption of "magic mushrooms." The present article offers an opportunity to find out what are the main symptoms of intoxication with mushrooms containing psilocybin/psilocin, muscimol, and ibotenic acid. The progress in analytical methods for detection of them in fungal material, food, and body fluids is reviewed. Findings on the mechanisms of their biologic activity are summarized. Additionally, therapeutic potential of these fungal psychoactive compounds and health risk associated with their abuse are discussed.

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Section: Methods Of Qualitative Analysis and Isolationmentioning

confidence: 99%

Fungal Hallucinogens Psilocin, Ibotenic Acid, and Muscimol

Stebelska

2013

Therapeutic Drug Monitoring

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“…13) Some of these, such as psilocin, baeocystin, norbaeocystin, bufotenin, and aerginascin, have psychoactive effects, although many hallucinogenic mushrooms produce smaller amounts of them than psilocybin. 13,14) These findings suggest that inhibition of marble-burying behavior by P. argentipes is due to the involvement of a variety of psychoactive substances.…”

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confidence: 89%

Effects ofPsilocybe argentipeson Marble-Burying Behavior in Mice

Matsushima

Shirota

Kikura‐Hanajiri³

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. These findings suggest that P. argentipes would be efficient in clinical obsessive-compulsive disorder therapy.

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“…1e). Also this compound obtained its name from the mushroom species were it was identified Inocybe aeruginascens after extraction with polar solvents (Gartz, 1989a;Jensen et al, 2006).…”

Section: Identity Physical and Chemical Properties 21 Identitymentioning

confidence: 99%