Effects ofPsilocybe argentipeson Marble-Burying Behavior in Mice

Abstract

Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. These findings suggest that P. argentipes would be efficient in clinical obsessive-compulsive disorder therapy.

Delayed Anxiolytic-Like Effects of Psilocybin in Male Mice Are Supported by Acute Glucocorticoid Release

“…[13][14][15][16][17][18][19] Additional studies assessing antidepressant-like and anxiolytic-like effects following treatment with 5-HT2AR agonists in rodent behavioral tests like the Forced Swim Test (FST), Open Field Test (OFT), and Elevated Plus Maze (EPM) have also emerged more recently. [19][20][21][22][23][24][25][26] The observed results have sometimes been consistent with interpretations of antidepressant-like or anxiolytic-like activity, such as reductions in FST immobility time and increased open arm time in the EPM. However, there have also been results that are inconsistent with this interpretation, such as a lack of effect on FST in Flinders' Sensitive Rats for up to a week after single or repeated psilocybin dosing.…”

Psychedelics

“…Matsushima et al (2009) studied the effect of psilocybin and the dried and powdered mycelium of a psilocybin-containing mushroom Psilocybe argentipes on marble-burying behavior in male mice. P. argentipes at a dose of 0.1-1 g/kg significantly reduced the number of buried marbles without reducing locomotor behavior.…”

A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive–compulsive disorder: Mapping the way forward

“…The number of marbles that have been buried is then counted by an observer, who is often blind to the treatment status of the subjects (Angoa-Pérez et al, 2013;Egashira et al, 2018;Millan et al, 2002). Importantly, since the majority of investigations do not distinguish between the specific behavioral patterns resulting in marbles being lowered into the burying substrate Gaikwad & Parle, 2011;Gomes, Casarotto, Resstel, & Guimarães, 2011;Harasawa, Ago, Itoh, Baba, & Matsuda, 2006;Honda, Kawaura, Soeda, Shirasaki, & Takahama, 2011;Li et al, 2006;Matsushima, Shirota, Kikura-Hanajiri, Goda, & Eguchi, 2009;Shimazaki, Iijima, & Chaki, 2004;Umathe et al, 2012;Yamada et al, 2002), the term Bburied^is generally applied to indicate the number of covered marbles. Although the reported methodologies always refer to the duration of exposure as well as the number of marbles and the burying substrate used, several experimental variables are subject to modification, either intentionally or not.…”

“…SSRI treatment, acting via increased synaptic 5-HT concentrations (Goddard et al, 2008), is the first line choice for the treatment of both anxiety (Bandelow et al, 2012;Bandelow et al, 2008) and OCD (Abramowitz et al, 2009;Fineberg, 2004), and has been well studied with the MBT (Table 1). These agents include fluoxetine (Kalariya, Prajapati, Parmar, & Sheth, 2015;Prajapati, Kalaria, Karkare, Parmar, & Sheth, 2011;Uday et al, 2007), fluvoxamine (Harasawa et al, 2006;Matsushima et al, 2009), citalopram (Krass et al, 2010;Li et al, 2006), and paroxetine (Casarotto et al, 2010;Saadat et al, 2006). Furthermore, like the 5-HT releaser fenfluramine (Njung'e & Handley, 1991a),…”