2007
DOI: 10.1089/sur.2006.051
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Aerosolized Tobramycin in The Treatment of Ventilator-Associated Pneumonia: A Pilot Study

Abstract: Aerosolized tobramycin for the treatment of VAP appeared safe and effective in this pilot study. A larger study is warranted to determine if aerosolized tobramycin will lead to better outcomes than intravenous tobramycin when used for the treatment of VAP.

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Cited by 75 publications
(70 citation statements)
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“…Several studies, most of them with small samples, have shown good outcomes in patients with VAP due to MDRAcinetobacter spp. treated with colistin [9], high-dose ampicillin-sulbactam [10], tetracyclines [11](doxycycline or minocycline) or aerosolized tobramycin [12]. However, the recorded clinical experience with these antibiotics is still limited and the reported studies of their use in the treatment of VAP are not randomized controlled clinical trials.…”
Section: Discussionmentioning
confidence: 99%
“…Several studies, most of them with small samples, have shown good outcomes in patients with VAP due to MDRAcinetobacter spp. treated with colistin [9], high-dose ampicillin-sulbactam [10], tetracyclines [11](doxycycline or minocycline) or aerosolized tobramycin [12]. However, the recorded clinical experience with these antibiotics is still limited and the reported studies of their use in the treatment of VAP are not randomized controlled clinical trials.…”
Section: Discussionmentioning
confidence: 99%
“…Ингаляционные ан тибиотики не используются в качестве монотерапии без системных препаратов, т. к. степень их адсорб ции в кровь низка (2-4 %) и недостаточна для лече ния сопутствующих НП инфекций. Частота побоч ных эффектов (нефро и нейротоксичность) при применении ингаляционных антибиотиков невысо ка [7,[12][13][14][15][16][17][18].…”
Section: заметки из практикиunclassified
“…and inhaled tobramycin (291). Patients with clinical symptoms of VAP or a new pulmonary infiltrate on a chest radiograph after 96 h of intubation were eligible for the study.…”
Section: Nosocomial Pneumoniamentioning
confidence: 99%