The intermediate duct connects high-pressure and low-pressure compressors. It comprises flow channels and struts that fix the relative positions of the hub and shroud. The mechanism of airflow movement around the struts in the downstream intermediate ducts is experimentally investigated based on four cases, including two types of struts and two shapes of meridional flow channels. The measurement parameters of the intermediate duct under the same conditions are measured in the wind tunnel, including the total pressure loss coefficient at the outlet and axial wall pressure distribution. In addition, the flow characteristics near the wall are obtained through the oil flow test, and the frequency of the shedding vortex is captured by the dynamic pressure probes. The results demonstrate that the strut and channel with the modified profile can reduce the total pressure loss and eliminate wake oscillation by changing the flow characteristic. The total pressure losses of the modified profile at 0.2, 0.25, 0.3, 0.35, 0.4, and 0.45 Ma conditions are reduced by 60%, 63%, 83%, 89%, 85%, and 87%, respectively.