Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials

Kelley, George A.; Kelley, Kristi S.

doi:10.1016/j.atherosclerosis.2005.04.005

Cited by 80 publications

(48 citation statements)

References 41 publications

(193 reference statements)

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“…The net increase of HDL-cholesterol was significant when the weekly estimated energy expenditure was greater than 900 kcal and total exercise duration per week was greater than 120 minutes. According to a meta-analysis of 19 RCTs of aerobic exercise training programs of at least 8 weeks, including 2 RCTs from Japan 61,62) , aerobic exercise increased HDL2-cholesterol levels significantly by 2.6 mg/dL (95% CI 1.0 to 4.4 mg/dL) 70) . Our searches turned up no RCTs on exercise training and CVD outcomes in Japan.…”

Section: Physical Activity and Blood Lipid Levelsmentioning

confidence: 99%

Physical Activity in the Japan Population: Association with Blood Lipid Levels and Effects in Reducing Cardiovascular and All-Cause Mortality

Koba

Tanaka

Maruyama

et al. 2011

JAT

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According to many prospective cohort studies and meta-analyses of those studies, physical inactivity and/or low levels of physical fitness are associated with an elevated risk for the development of metabolic syndrome, type 2 diabetes, hypertension, coronary artery disease (CAD), and stroke, and with an increased risk of cardiovascular disease (CVD) mortality and all-cause mortality. Most of these analyses, however, were conducted on non-Japanese populations in the West. This report summarizes prospective observational and clinical studies in Japan. The annual national nutrition survey has shown a gradual decline in the number of walking steps in both genders and in all age groups over the last 10 years. While exercise habits have been gradually increasing in the elderly, only one-fifth of young and middle-aged people undertake leisure-time physical activity. Prospective cohort studies have shown that increased physical fitness and greater physical activity in either daily life or leisure time are of benefit in preventing all-cause mortality and CVD mortality. The daily number of walking steps is positively associated with HDL cholesterol levels and negatively associated with triglyceride levels. According to a random-effects model meta-analysis of 4 randomized controlled trials comparing supervised aerobic exercise training with non-exercise control in subjects without CAD, exercise resulted in a significant increase in HDL-cholesterol (10.01 mg/dL, 95% CI 5.38 to 14.65, p 0.0001). While this confirms the importance of physical activity in preventing CVD mortality and all-cause mortality, the levels of physical activity are on a declining trend in Japan, particularly among the young.

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Section: Physical Activity and Blood Lipid Levelsmentioning

confidence: 99%

Physical Activity in the Japan Population: Association with Blood Lipid Levels and Effects in Reducing Cardiovascular and All-Cause Mortality

Koba

Tanaka

Maruyama

et al. 2011

JAT

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“…The causal relationship between blood HDL-C levels and CAD has been explained by the involvement of these lipoproteins in reverse cholesterol transport, as well as by other potentially antiatherogenic properties of HDL, such as its antioxidative enzymes and other effects 1) . Because the major role of HDL2-C appears to be as a final receptor in the reverse cholesterol transport process, increases in HDL2-C as a result of aerobic exercise occurred independently of changes in physical characteristics, and statistically significant increases were found in HDL2-C but not important in HDL-C 42) . In addition, of the two major HDL-C subfractions, HDL2-C may provide greater protection against CAD than HDL3-C 62) .…”

Section: Effects Of Exercise On Hdls and Clinical Significancementioning

confidence: 96%

“…In addition, of the two major HDL-C subfractions, HDL2-C may provide greater protection against CAD than HDL3-C 62) . Therefore, no increase in HDL-C in the clinical setting may not be indicative of a lack of cardioprotection within this lipoprotein group 42) . Therefore, it may be important to determine PON1 and AE activities and the cholesterol contents of HDLs to control HDL functions.…”

Section: Effects Of Exercise On Hdls and Clinical Significancementioning

confidence: 97%

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Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

Turgay

Şişman

Aksu

2015

JAT

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Aim: Paraoxonase-1 (PON1) is an antiatherosclerotic enzyme located on high-density lipoprotein (HDL). The effects of anaerobic exercise on PON1 activity are unknown. Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1), including basal PON1, salt-stimulated PON1 (SPON1), and arylesterase (AE) activities, of serum, HDL, and HDL subgroups (HDLs; HDL and its subgroups) and its relationship with PON1-Q192R phenotype (PON1P). Methods: Our study included 18 Turkish national female judoists (mean age: 17.9 0.8 years). Before and after 5 months of anaerobic training, critical speed (CS), TDPON1 activities, cholesterol levels in the serum and supernatants of HDLs obtained by polyethylene glycol, and other major blood lipids and lipoproteins (BLLPs) including triglycerides were determined using blood samples taken after overnight fasting. PON1P groups (PGs) were categorized as QQ (QG; persons with low activity) and R carriers (QR RR) (RG; persons with high activity) according to SPON1/AE activity ratios. The results were considered statistically significant at P ≤ 0.05. Results: Anaerobic training resulted in significantly increased the cholesterol levels of HDLs (except HDL2-C) in all subjects, but not HDLs-C in PGs. Anaerobic training resulted in significant increases in most TDPON1 activities of serum and HDLs in all subjects and (except AE) in PGs, whereas SPON1 and HDL2 AE activities increased only in the RG, which was related to PON1P. However, PON1P was not related to other measured markers, including basal BLLP profiles. Conclusions: Anaerobic training improved most TDPON1 activities of serum and HDLs and HDLs -C levels (except HDL2-C) in all subjects, but not HDLs-C in PGs. The beneficial effects of anaerobic training on SPON1 and HDL2 AE activities were depend on PON1P. The lack of response of HDL2-C to anaerobic exercise will require further research. J Atheroscler Thromb, 2015; 22: 313-326.

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“…Moreover, it is associated with increase of the activity of the lipoprotein lipase (LPL) and lecitin-cholesterol aciltransferase (LCAT) enzymes and reduction in the CETP activity. Therefore, physical exercise affects the lipoproteins metabolism, influencing on the cholesterol reverse transport as well as the TG-rich lipoproteins metabolism 5 . These effects may be intensified when associated with low-fat diet, especially saturated ones, decrease in body weight and reduction of adiposity 6 .…”

Section: Introductionmentioning

confidence: 99%

Efeito do exercício físico e estatinas na função muscular em animais com dislipidemia

Accioly

Filho

Padulla

et al. 2012

Rev Bras Med Esporte

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As estatinas são utilizadas no tratamento das dislipidemias, com grande tolerância; no entanto, vários efeitos colaterais podem surgir, destacando-se miopatia. A prática regular do exercício físico (EF) produz modificações favoráveis no perfil lipídico; entretanto, pode gerar lesões musculares. OBJETIVO: Avaliar o efeito da associação entre exercício físico e estatinas na função muscular, pela análise histológica, em modelo experimental animal com dislipidemia. MÉTODOS: Foram utilizados 80 ratos machos Wistar, distribuídos em oito grupos, incluindo animais submetidos à dieta hipercolesterolêmica (DH), sinvastatina com (G1) e sem (G2) EF; DH e fluvastatina, com (G3) e sem EF (G4); alimentados com ração comercial (RC) na presença (G5) e ausência de (G6) EF; DH submetidos (G7) ou não (G8) a EF. A DH foi administrada por 90 dias, as estatinas e prática de EF em esteira rolante por oito semanas. Os animais foram sacrificados, e o músculo sóleo retirado para análise histológica. Aplicaram-se os testes t de Student pareado e análise multivariada, com nível significante para p < 0,05. RESULTADOS: As principais alterações histológicas encontradas foram fibras de diferentes diâmetros, atróficas, em degeneração, splitting, edema, infiltrado inflamatório. Essas alterações foram observadas em 90% dos animais do grupo G1, 80% do G2, 70% do G3, 30% do G4, 40% do G5 e 30% do G7. Nos grupos G6 e G8 identificaram-se fibras musculares com morfologia preservada. CONCLUSÕES: Na avaliação histológica muscular, a associação entre fluvastatina, sinvastatina e exercício físico acarreta alterações morfológicas com predomínio no uso da sinvastatina, variando de grau leve a grave, no músculo sóleo de ratos, induzidos pelos inibidores da HMG-CoA redutase.

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Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials

Cited by 80 publications

References 41 publications

Physical Activity in the Japan Population: Association with Blood Lipid Levels and Effects in Reducing Cardiovascular and All-Cause Mortality

Physical Activity in the Japan Population: Association with Blood Lipid Levels and Effects in Reducing Cardiovascular and All-Cause Mortality

Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

Efeito do exercício físico e estatinas na função muscular em animais com dislipidemia

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