Spreading of dengue fever after globalization presents an emerging worldwide threating especially in tropical and subtropical regions. Co-infections of Dengue virus (DENV), Zika, virus (ZIKV) and Chikkungunya virus (CHIKV) are Aedes mosquito-borne diseases reported in some countries. Climate change is likely to increase global outbreaks incidence of Aedes-borne arboviruses has been more frequent and more intense in the recent years. Unfortunately, current evidence suggests that climatic changes can be partially driving recent mosquito-borne diseases outbreaks worldwide. Besides, the global climatic change already made the conditions more suitable for risk spreading of certain zoonotic vector-borne diseases to non-endemic countries. The areas with risk of dengue are changing.