Background: Tuberculosis still remain as a health problem in the world. No specific biomarkers can be used to monitor the rapid response to TB therapy. This study aims to assess the change of IL-17 levels in pulmonary tuberculosis patients with AFB smear-positive before and after 2 months of anti tuberculosis drugs (ATD) treatment.
Method: Design of study is analytic observational with prospective cohort. The subject include 17 new cases of pulmonary tuberculosis patients with AFB smear-positive in Soetomo Hospital Surabaya from July - October 2016. Plasma levels of IL-17 were measured using ELISA technique before treatment and 2 months after the ATD therapy.
Results: The mean levels of IL-17 before treatment is 3.510 pg / ml (2.087- 5.051 pg/ml). There were significantly decreament (p = 0.001
Dengue fever is infectious disease caused by dengue virus. Climate change, especially warming temperature is associated with the spread of Aedes aegypti which is the main vector for dengue virus. Antibiotics for dengue infection are used to prevent secondary infection. Thus, hospitalized patients treated with antibiotics are suspected to be associated with days reduction of hospitalization. It is important to monitor the patients’ temperature as it becomes the sign of worseness or recovery. This study aims to determine whether there is relationship between antibiotic treatment with length of stay and daily temperature of child patients infected by dengue. The study was conducted at UNS Hospital Indonesia. A total data of 180 children hospitalized with dengue infection since 2019 to 2020 were analyzed. Confirmation to parents was done when needed. Data were analyzed using Mann-Whitney and Fisher’s test. There was insignificant relationship between antibiotics treatment with length of stay (p-value = 0.48) and daily temperature (p-value = 0.078) of child patients infected by dengue at UNS Hospital. There was no significant relationship between antibiotic treatment with length of stay and daily temperature fluctuation. Further study to investigate other factors which affect the length of stay and daily temperature fluctuation is needed.
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