Adverse health outcomes associated with fetal alcohol exposure: A systematic review focused on immune‐related outcomes

Reid, Natasha; Akison, Lisa K.

doi:10.1111/pai.13099

Cited by 34 publications

(22 citation statements)

References 48 publications

(163 reference statements)

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“…Strategic treatments eliminate tangible factors that contribute to weaken the immune system. Some examples of such factors, based on existing studies, include titanium dioxide, air pollution, chlorpyrifos, aluminum sulfate, prenatal alcohol exposure, ZnO, oil fly ash, and many others (3)(4)(5)(6)(7)(8)(9). Also the real life exposure scenario in which we are exposed continuously to combination of stressors influences in the long term the immune system and the response of the organism to the viral stressors (10)(11)(12)(13)(14).…”

Section: Towards Effective Covid-19 Vaccines: Updates Perspectives Amentioning

confidence: 99%

Towards effective COVID‑19 vaccines: Updates, perspectives and challenges (Review)

et al. 2020

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In the current context of the pandemic triggered by SARS-cOV-2, the immunization of the population through vaccination is recognized as a public health priority. In the case of SARS-cOV-2, the genetic sequencing was done quickly, in one month. Since then, worldwide research has focused on obtaining a vaccine. This has a major economic impact because new technological platforms and advanced genetic engineering procedures are required to obtain a cOVId-19 vaccine. The most difficult scientific challenge for this future vaccine obtained in the laboratory is the proof of clinical safety and efficacy. The biggest challenge of manufacturing is the construction and validation of production platforms capable of making the vaccine on a large scale.

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Section: Towards Effective Covid-19 Vaccines: Updates Perspectives Amentioning

confidence: 99%

Towards effective COVID‑19 vaccines: Updates, perspectives and challenges (Review)

et al. 2020

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“…8 More recently, the life course consequences of exposure to perinatal environmental toxins due to maternal smoking, pollution, alcohol, and consumption of drugs of abuse have increased the scope of intensive programming investigations. 9,10 Epidemiological studies typically employ public medical databases and focus on diagnostic end points. This approach provides powerful distribution patterns, but lacks the ability to determine causative mechanisms by which malnutrition and other early challenges alter the physiology of maturation, life course disease pathology, and aging.…”

Section: Dohad and Heart Diseasementioning

confidence: 99%

Cardiac magnetic resonance imaging: insights into developmental programming and its consequences for aging

Clarke

Kuo

et al. 2020

J Dev Orig Health Dis

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Cardiovascular diseases (CVD) are important consequences of adverse perinatal conditions such as fetal hypoxia and maternal malnutrition. Cardiac magnetic resonance imaging (CMR) can produce a wealth of physiological information related to the development of the heart. This review outlines the current state of CMR technologies and describes the physiological biomarkers that can be measured. These phenotypes include impaired ventricular and atrial function, maladaptive ventricular remodeling, and the proliferation of myocardial steatosis and fibrosis. The discussion outlines the applications of CMR to understanding the developmental pathways leading to impaired cardiac function. The use of CMR, both in animal models of developmental programming and in human studies, is described. Specific examples are given in a baboon model of intrauterine growth restriction (IUGR). CMR offers great potential as a tool for understanding the sequence of dysfunctional adaptations of developmental origin that can affect the human cardiovascular system.

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“…The first study in this area, a small case study of children with fetal alcohol syndrome (FAS; at the most severe end of the FASD spectrum), showed that children with FAS had increased rates of major and minor infections compared to controls [21], and this increased infection risk associated with prenatal alcohol exposure has been replicated in other studies as well [22][23][24]. In addition, impairments in cell-mediated and humoral immunity [21] and increased risk of dermatitis [25], eczema [26], and certain cancers [27] have also been reported (reviewed in [28,29]). All of these immune-related changes may be a result of alcoholinduced programming of the immune system, altering the production and/or release of immune mediators.…”

Section: Introductionmentioning

confidence: 95%

Immune network dysregulation associated with child neurodevelopmental delay: modulatory role of prenatal alcohol exposure

Bodnar

Wertelecki

Yevtushok

et al. 2020

J Neuroinflammation

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Background: Evidence suggests that cytokine imbalances may be at the root of deficits that occur in numerous neurodevelopmental disorders, including schizophrenia and autism spectrum disorder. Notably, while clinical studies have demonstrated maternal cytokine imbalances with alcohol consumption during pregnancy-and data from animal models have identified immune disturbances in alcohol-exposed offspring-to date, immune alterations in alcohol-exposed children have not been explored. Thus, here we hypothesized that perturbations in the immune environment as a result of prenatal alcohol exposure will program the developing immune system, and result in immune dysfunction into childhood. Due to the important role of cytokines in brain development/function, we further hypothesized that child immune profiles might be associated with their neurodevelopmental status. Methods: As part of a longitudinal study in Ukraine, children of mothers reporting low/no alcohol consumption or moderate-to-heavy alcohol consumption during pregnancy were enrolled in the study and received neurodevelopmental assessments. Group stratification was based on maternal alcohol consumption and child neurodevelopmental status resulting in the following groups: A/TD, alcohol-consuming mother, typically developing child; A/ND, alcohol-consuming mother, neurodevelopmental delay in the child; C/TD, control mother (low/no alcohol consumption), typically development child; and C/ND, control mother, neurodevelopmental delay in the child. Forty cytokines/chemokines were measured in plasma and data were analyzed using regression and constrained principle component analysis. Results: Analyses revealed differential cytokine network activity associated with both prenatal alcohol exposure and neurodevelopmental status. Specifically, alcohol-exposed children showed activation of a cytokine network including eotaxin-3, eotaxin, and bFGF, irrespective of neurodevelopmental status. However, another cytokine network was differentially activated based on neurodevelopmental outcome: A/TD showed activation of MIP-1β, MDC, and MCP-4, and inhibition of CRP and PlGF, with opposing pattern of activation/inhibition detected in the A/ND group. By contrast, in the absence of alcohol-exposure, activation of a network including IL-2, TNF-β, IL-10, and IL-15 was associated with neurodevelopmental delay.

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Adverse health outcomes associated with fetal alcohol exposure: A systematic review focused on immune‐related outcomes

Cited by 34 publications

References 48 publications

Towards effective COVID‑19 vaccines: Updates, perspectives and challenges (Review)

Towards effective COVID‑19 vaccines: Updates, perspectives and challenges (Review)

Cardiac magnetic resonance imaging: insights into developmental programming and its consequences for aging

Immune network dysregulation associated with child neurodevelopmental delay: modulatory role of prenatal alcohol exposure

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