Cardiac magnetic resonance imaging: insights into developmental programming and its consequences for aging

Clarke, Geoffrey D.; Li, J; Kuo, Anderson H.; Moody, Alexander J; Nathanielsz, Peter W.

doi:10.1017/s2040174420001233

Cited by 6 publications

(4 citation statements)

References 133 publications

(140 reference statements)

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“…Tag:MYC ) (Dupont et al, 2012). In the present study, multiple networks of DE (Hartl, 2016) and developmental growth (Clarke et al, 2020), are clearly related to ageing. Specifically, multiple GO terms, including inorganic ion homeostasis, cation homeostasis, and cellular calcium ion homeostasis, are involved in regulating the sequestration of calcium ions.…”

Section: Discussionsupporting

confidence: 56%

Age-related ceRNA networks in adult Drosophila ageing

Yang

Xiao²,

Li³

et al. 2023

Front. Genet.

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As Drosophila is an extensively used genetic model system, understanding of its regulatory networks has great significance in revealing the genetic mechanisms of ageing and human diseases. Competing endogenous RNA (ceRNA)-mediated regulation is an important mechanism by which circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) regulate ageing and age-related diseases. However, extensive analyses of the multiomics (circRNA/miRNA/mRNA and lncRNA/miRNA/mRNA) characteristics of adult Drosophila during ageing have not been reported. Here, differentially expressed circRNAs and microRNAs (miRNAs) between 7 and 42-day-old flies were screened and identified. Then, the differentially expressed mRNAs, circRNAs, miRNAs, and lncRNAs between the 7- and 42-day old flies were analysed to identify age-related circRNA/miRNA/mRNA and lncRNA/miRNA/mRNA networks in ageing Drosophila. Several key ceRNA networks were identified, such as the dme_circ_0009500/dme_miR-289-5p/CG31064, dme_circ_0009500/dme_miR-289-5p/frizzled, dme_circ_0009500/dme_miR-985-3p/Abl, and XLOC_027736/dme_miR-985-3p/Abl XLOC_189909/dme_miR-985-3p/Abl networks. Furthermore, real-time quantitative PCR (qPCR) was used to verify the expression level of those genes. Those results suggest that the discovery of these ceRNA networks in ageing adult Drosophila provide new information for research on human ageing and age-related diseases.

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Section: Discussionsupporting

confidence: 56%

Age-related ceRNA networks in adult Drosophila ageing

Yang

Xiao²,

Li³

et al. 2023

Front. Genet.

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“…In this regard, fetal CMR provides a well-established technique for measuring blood flow, which may add additional hemodynamic information beyond Doppler assessment of blood velocity [17]. Fetal CMR allows information about qualitative imaging biomarkers to be obtained, with the final purpose of understanding the biological processes of cardiovascular fetal programming [28].…”

Section: Application Of Fetal Cmr Imaging In Understanding Chdmentioning

confidence: 99%

Utility of Fetal Cardiac Resonance Imaging in Prenatal Clinical Practice: Current State of the Art

Pozza,

Reffo,

Castaldi

et al. 2023

Diagnostics

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The field of prenatal cardiac imaging has revolutionized the way we understand and manage congenital heart diseases (CHD) in the developing fetus. In the prenatal period, cardiac imaging plays a pivotal role in the diagnostic pathway, from screening to classification and follow-up of CHD. The ability to visualize the fetal heart in utero allows healthcare professionals to detect abnormalities early, thus enabling timely interventions and informed decision-making processes for both the mother and the medical team. Early CHD detection improves preparation for delivery, postnatal care, and postnatal outcomes. Advancements in medical technology and imaging techniques have provided clinicians with insights into the fascinating workings of the fetal heart. Several imaging modalities have proven to be helpful in this field, with echocardiography undoubtedly representing the primary modality for evaluating the fetus. By providing detailed anatomical and functional information, fetal cardiac magnetic resonance (CMR) imaging contributes to better prenatal counseling and enhances the coordination of care between obstetricians, maternal–fetal medicine specialists, and pediatric cardiologists. Shortcomings of fetal CMR are due to technical concerns related to the intrauterine position of the fetus and subsequent challenges to following a standard scan protocol. The aim of this paper was to revise the current state-of-the-art in the field of fetal CMR and its clinical applications and to delve into methods, challenges, and future directions of fetal CMR in prenatal imaging.

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“…Cardiac magnetic resonance imaging (MRI) refers to the diagnosis of heart and vascular diseases through MRI technology, which is noninvasive [12,13]. This procedure can be applied to patients of all ages with good soft tissue comparison resolution; a large scanning field of view and patient detection images can be obtained from various angles [14][15][16]. With the development of medical technology and the increase in clinical demand, cardiac MRI has been widely used in the diagnosis of heart-related diseases; it can be used to evaluate the cardiac status and myocardial tissue function of patients in a noninvasive manner and has a high value for clinical diagnosis [17,18].…”

Section: Introductionmentioning

confidence: 99%

Continuous Cardiac Magnetic Resonance Imaging after Coronary Revascularization for Left Ventricular Dysfunction

Ding,

Shu,

Chen

2024

HSF

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Objective: To determine the contribution of serial cardiac magnetic resonance imaging (MRI) following coronary revascularization (CR) to the clinical management of patients with left ventricular insufficiency. Methods: The study objects comprised the clinical data of 145 patients with CR undergoing CR surgery for left ventricular insufficiency in our hospital from January 2021 to January 2023. The patients were divided into the case (n = 35, left ventricular ejection fraction (LVEF) <50%) and control (n = 110, LVEF ≥50%) groups based on the LVEF recorded in the medical record system 6 months after surgery. Preoperative LVEF left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume index (LVEDVI), left ventricular end-systolic volume index (LVESVI), cardiac index (CI), and other cardiac magnetic resonance detection parameters were compared. Logistic regression analysis was performed to analyze the prognostic factors of patients undergoing CR after CR surgery for left ventricular insufficiency. The receiver operating characteristic curve was drawn, the sensitivity, specificity, and area under curve (AUC) were calculated, and the best prediction threshold was determined. The prognostic value of cardiac MRI in CR surgery for left ventricular dysfunction was observed. Results: Cardiac MRI revealed that the case group had higher LVEDV, LVESV, LVEDVI, LVESVI, and CI than the control group. However, the LVEF index was lower than that in the control group (p < 0.05). Logistic regression analysis was conducted for indicators with differences, and the results indicate LVEF as a protective factor for the postoperative efficacy of the patients, with an odds ratio (OR) <1. LVEDV, LVESV, LVEDVI, LVESVI, and CI were all risk factors for the postoperative efficacy of the patients, with an OR >1. The AUC values of LVEF, LVEDV, LVESV, LVEDVI, LVESVI, and CI were 0.698, 0.674, 0.654, 0.700, 0.572, and 0.812, respectively. The optimal threshold values were 53.57%, 112.33 and 68.5 mL, and 205.51, 163.99, and 2.14 L/m2, and their corresponding sensitivities reached 0.618, 0.514, 0.654, 0.800, 0.371, and 0.829 for each index. The specificities were 0.800, 0.836, 0.771, 0.609, 0.836, and 0.645, which indicate that LVEF, LVEDV, LVESV, LVEDVI, LVESVI, and CI had a certain degree of predictive value for postoperative cardiac function recovery. Conclusion: LVEDV, LVESV, LVEDVI, LVESVI, CI, and LVEF are all factors affecting the clinical efficacy in patients undergoing CR after left ventricular insufficiency. In addition, cardiac MRI can effectively detect the above factors and effectively predict the postoperative efficacy among patients.

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Cardiac magnetic resonance imaging: insights into developmental programming and its consequences for aging

Cited by 6 publications

References 133 publications

Age-related ceRNA networks in adult Drosophila ageing

Age-related ceRNA networks in adult Drosophila ageing

Utility of Fetal Cardiac Resonance Imaging in Prenatal Clinical Practice: Current State of the Art

Continuous Cardiac Magnetic Resonance Imaging after Coronary Revascularization for Left Ventricular Dysfunction

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